Gut microbial similarity in twins is driven by shared environment and aging

Vílchez-Vargas, Ramiro; Skiecevičienė, Jurgita; Lehr, Konrad; Varkalaitė, Greta; Thon, Cosima; Urba, Mindaugas; Morkūnas, Egidijus; Kučinskas, Laimutis; Bauraitė, Karolina; Schanze, Denny; Zenker, Martin; Malfertheiner, P.; Kupčinskas, Juozas; Link, Alexander

doi:10.1016/j.ebiom.2022.104011

Cited by 14 publications

(13 citation statements)

References 43 publications

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“…In comparison to various other compartments, and specifically the colon, gastric microhabitats may be quite sensitive to environmental changes including pH, drugs, diet, and others, which may become more stable along the GI tract. The gastric microbiome of the corpus and antrum has been shown to have a low level of variation 6 , 8 , 9 , while interindividual variation between subjects, as supported by our data, is quite high. The main reason for this high level of interindividual variation in overall comparison was related to H. pylori, as the most crucial habitat of the stomach.…”

Section: Discussionsupporting

confidence: 87%

“…However, faecal samples, although easily accessible, offer only limited insight on the pathophysiological interaction between the gastric mucosa and microbiome 8 , 18 , 19 . Microbial GI tract mapping has recently revealed a distinct microbial community in the stomach in comparison to intestine and faeces 6 , 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Each individual harbours a unique composition of bacteria. Despite this high diversity, there are dominant bacterial genera in a healthy stomach like Gemella, Veillonella, Neisseria, Fusobacterium, Streptococcus, Prevotella, Pseudomonas, and Actinomyces [6][7][8][9] . Changes in the microbial community of the stomach are strongly driven by H. pylori positivity and less dependent on genetic factors 6 .…”

mentioning

confidence: 99%

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Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer

Lehr

Nikitina

Vílchez-Vargas

et al. 2023

Sci Rep

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Helicobacter pylori (H. pylori) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play an important role in pathophysiology of gastric cancer. The aim of the study was to explore the link between gastric cancer prognosis and the mucosal microbial community in tumorous and adjacent gastric tissue. The bacterial profile was analysed using 16S sequencing (V1–V2 region). Microbial differences were mostly characterized by lower relative abundances of H. pylori in tumorous gastric tissues. Bacterial community and outcome data analysis revealed the genus Fusobacterium and Prevotella significantly associated with worse overall survival in gastric cancer patients. In particular, Fusobacterium was associated with significant increase in hazard ratio in both univariable and multivariable analysis and independently validated using TCMA data. Phylogenetic biodiversity of Fusobacterium species in the stomach revealed F. periodonticum as the most prevalent in healthy subjects, while F. nucleatum was most abundant in patients with gastric cancer. Bacterial community network analysis in gastric cancer suggests substantial complexity and a strong interplay between F. nucleatum and Prevotella. In summary, mucosal microbial community in the stomach was associated with worse overall survival in gastric cancer patients. Strongest negative impact on prognosis was linked to the abundance of F. nucleatum in tumorous specimens, suggesting its translational relevance in management of gastric cancer patients.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer

Lehr

Nikitina

Vílchez-Vargas

et al. 2023

Sci Rep

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“…17 . Vilchez-Vargas et al 18 identified shared household and aging, but not host genetics , as factors in determining microbial similarity in fecal specimens of twins irrespective of zygosity. These findings emphasize the predominant role of environmental factors rather than host factors in defining the twins’ microbial composition 18 .…”

Section: Introductionmentioning

confidence: 99%

“…Vilchez-Vargas et al 18 identified shared household and aging, but not host genetics , as factors in determining microbial similarity in fecal specimens of twins irrespective of zygosity. These findings emphasize the predominant role of environmental factors rather than host factors in defining the twins’ microbial composition 18 . In contrast, microbiome differences between participants, disease versus healthy, may be overpowered by interindividual variability in the microbiota in contemporary cross-sectional designs 15 .…”

Section: Introductionmentioning

confidence: 99%

Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study

Delanote,

Correa Rojo,

Wells

et al. 2024

Sci Rep

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Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and eating disorders remain poorly understood. Currently, there are no robust biomarkers identified. We proposed a novel pyramid-layer design to accurately identify microbial/metabolomic signatures underlying mental disorders in the TwinsUK registry. Monozygotic and dizygotic twins discordant for mental disorders were screened, in a pairwise manner, for differentially abundant bacterial genera and circulating metabolites. In addition, multivariate analyses were performed, accounting for individual-level confounders. Our pyramid-layer study design allowed us to overcome the limitations of cross-sectional study designs with significant confounder effects and resulted in an association of the abundance of genus Parabacteroides with the diagnosis of mental disorders. Future research should explore the potential role of Parabacteroides as a mediator of mental health status. Our results indicate the potential role of the microbiome as a modifier in mental disorders that might contribute to the development of novel methodologies to assess personal risk and intervention strategies.

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Einflussfaktoren auf das gastrointestinale Mikrobiom

Macke,

Vasapolli

2024

Gastrointestinales Mikrobiom

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Gut microbial similarity in twins is driven by shared environment and aging

Cited by 14 publications

References 43 publications

Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer

Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer

Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study

Einflussfaktoren auf das gastrointestinale Mikrobiom

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