Gut microbiome alterations in breast cancer survivors with cancer-related fatigue.

Chan, Alexandre; Shwe, Maung; Koh, Samantha An Qi; Zhu, Congju; Chan, Y S; Tan, Si Hui; Ang, Xiao Jun; Lee, Wei Quan; Khine, Wei Wei Thwe; Lee, Yuan Kun; Lau, Quek Choon

doi:10.1200/jco.2018.36.15_suppl.e22178

Cited by 4 publications

(3 citation statements)

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“…Comparable symptoms of fatigue, cognitive dysfunction, and gut microbiome changes have been observed in patients with post-acute sequelae of SARS-CoV-2 infection, or “long Covid” [ 106 , 107 ], and chronic fatigue syndrome [ 108 , 109 ], among other disorders [ 110 , 111 , 112 ]. While one study found no differences in gut microbiome diversity based on level of fatigue [ 113 ], two studies did report an association between fatigue and changes to the gut microbiome in cancer patients or survivors [ 49 , 50 ]. Additionally, one of these studies found that patients in the high fatigue group had a greater abundance of taxa linked to inflammation [ 50 ], while the other found that relative abundance of certain taxa correlated with neurocognitive capacity in cancer survivors [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…While one study found no differences in gut microbiome diversity based on level of fatigue [ 113 ], two studies did report an association between fatigue and changes to the gut microbiome in cancer patients or survivors [ 49 , 50 ]. Additionally, one of these studies found that patients in the high fatigue group had a greater abundance of taxa linked to inflammation [ 50 ], while the other found that relative abundance of certain taxa correlated with neurocognitive capacity in cancer survivors [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although diet has received little attention in CRF, diet quality has been associated with reduced fatigue in a cross-sectional study of breast cancer survivors following primary treatment [ 46 ]. This may be due to dietary effects on the gut microbiome [ 47 , 48 ], which has been linked to fatigue in cancer patients and survivors [ 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial

et al. 2022

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Many cancer patients undergoing treatment experience cancer-related fatigue (CRF). Inflammatory markers are correlated with CRF but are not routinely targeted for treatment. We previously demonstrated in an NIH-funded placebo-controlled, double-blind, randomized clinical trial (NCT00878995, closed to follow-up) that seven weekly injections of 100 mg adjunct testosterone preserved lean body mass in cancer patients undergoing standard-of-care treatment in a hospital setting. Because testosterone therapy can reduce circulating proinflammatory cytokines, we conducted an ancillary analysis to determine if this testosterone treatment reduced inflammatory burden and improved CRF symptoms and health-related quality of life. Randomization was computer-generated and managed by the pharmacy, which dispensed testosterone and placebo in opaque syringes to the administering study personnel. A total of 24 patients were randomized (14 placebo, 10 testosterone), and 21 were included in the primary analysis (11 placebo, 10 testosterone). Testosterone therapy did not ameliorate CRF symptoms (placebo to testosterone difference in predicted mean multidimensional fatigue symptom inventory scores: −5.6, 95% CI: −24.6 to 13.3), improve inflammatory markers, or preserve health-related quality of life and functional measures of performance in late-stage cancer patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial

et al. 2022

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Human gut-microbiome interplay: Analysis of clinical studies for the emerging roles of diagnostic microbiology in inflammation, oncogenesis and cancer management

Jiang

Chen

et al. 2021

Infection, Genetics and Evolution

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Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis

et al. 2021

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Obesity and poor diet often go hand-in-hand, altering metabolic signaling and thereby impacting breast cancer risk and outcomes. We have recently demonstrated that dietary patterns modulate mammary microbiota populations. An important and largely open question is whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer. To address this, we performed fecal transplants between mice on control or high-fat diets (HFD) and recorded mammary tumor outcomes in a chemical carcinogenesis model. HFD induced protumorigenic effects, which could be mimicked in animals fed a control diet by transplanting HFD-derived microbiota. Fecal transplants altered both the gut and mammary tumor microbiota populations, suggesting a link between the gut and breast microbiomes. HFD increased serum levels of bacterial lipopolysaccharide (LPS), and control diet–derived fecal transplant reduced LPS bioavailability in HFD-fed animals. In vitro models of the normal breast epithelium showed that LPS disrupts tight junctions (TJ) and compromises epithelial permeability. In mice, HFD or fecal transplant from animals on HFD reduced expression of TJ-associated genes in the gut and mammary gland. Furthermore, infecting breast cancer cells with an HFD-derived microbiome increased proliferation, implicating tumor-associated bacteria in cancer signaling. In a double-blind placebo-controlled clinical trial of patients with breast cancer administered fish oil supplements before primary tumor resection, dietary intervention modulated the microbiota in tumors and normal breast tissue. This study demonstrates a link between the gut and breast that mediates the effect of diet on cancer. Significance: This study demonstrates that diet shifts the microbiome in the gut and the breast tumor microenvironment to affect tumorigenesis, and oral dietary interventions can modulate the tumor microbiota in patients with breast cancer.

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Gut microbiome alterations in breast cancer survivors with cancer-related fatigue.

Cited by 4 publications

References 0 publications

Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial

Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial

Human gut-microbiome interplay: Analysis of clinical studies for the emerging roles of diagnostic microbiology in inflammation, oncogenesis and cancer management

Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis

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