Gut microbiome and anticancer immune response: really hot Sh*t!

Viaud, Sophie; Daillère, Romain; Boneca, Ivo Gomperts; Lepage, Patricia; Langella, Philippe; Chamaillard, Mathias; Pittet, Mikaël J.; Ghiringhelli, François; Trinchieri, Giorgio; Goldszmid, Romina S.; Zitvogel, Laurence

doi:10.1038/cdd.2014.56

Cited by 113 publications

(102 citation statements)

References 135 publications

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“…Recent discoveries highlight the impact of gut microbiota on the effectiveness of some ICD inducers like cyclophosphamide and oxaliplatin [66][67][68]. Chemotherapeutics produce damage in the intestine and increase the gut permeability resulting in selective translocation of Gram-positive bacteria into secondary lymphoid organs.…”

Section: Cisplatin Oxaliplatin and Icdmentioning

confidence: 99%

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Anticancer metal drugs and immunogenic cell death

Terenzi

Pirker

Keppler

et al. 2016

Journal of Inorganic Biochemistry

122

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Section: Cisplatin Oxaliplatin and Icdmentioning

confidence: 99%

“…Taken together, the gut microbiome seems to be important for anticancer immune responses independent if the used drug can induce ICD. However, if and how intestinal and systemic immunity are interconnected to modulate the effects of systemic anticancer therapy still needs to be elucidated [68].…”

Section: Cisplatin Oxaliplatin and Icdmentioning

confidence: 99%

Anticancer metal drugs and immunogenic cell death

Terenzi

Pirker

Keppler

et al. 2016

Journal of Inorganic Biochemistry

122

View full text Add to dashboard Cite

“…For example, the microbiome in the human gut has been linked with a healthy function of the brain, the immune system, the digestive system, and with a number of diseases ranging from cancer to metabolic or even psychiatric disorders (Foster & McVey Neufeld, 2013;Biedermann & Rogler, 2015;Dash et al, 2015;Viaud et al, 2015). In animals, the microbiome has been associated with similar functions in development and disease (Engel & Moran, 2013;Kostic et al, 2013;Sabree & Moran, 2014).…”

Section: Introductionmentioning

confidence: 99%

The microbiome of the leaf surface of Arabidopsis protects against a fungal pathogen

et al. 2016

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SummaryWe have explored the importance of the phyllosphere microbiome in plant resistance in the cuticle mutants bdg (BODYGUARD) or lacs2.3 (LONG CHAIN FATTY ACID SYNTHASE 2) that are strongly resistant to the fungal pathogen Botrytis cinerea.The study includes infection of plants under sterile conditions, 16S ribosomal DNA sequencing of the phyllosphere microbiome, and isolation and high coverage sequencing of bacteria from the phyllosphere.When inoculated under sterile conditions bdg became as susceptible as wild-type (WT) plants whereas lacs2.3 mutants retained the resistance. Adding washes of its phyllosphere microbiome could restore the resistance of bdg mutants, whereas the resistance of lacs2.3 results from endogenous mechanisms. The phyllosphere microbiome showed distinct populations in WT plants compared to cuticle mutants. One species identified as Pseudomonas sp isolated from the microbiome of bdg provided resistance to B. cinerea on Arabidopsis thaliana as well as on apple fruits. No direct activity was observed against B. cinerea and the action of the bacterium required the plant.Thus, microbes present on the plant surface contribute to the resistance to B. cinerea. These results open new perspectives on the function of the leaf microbiome in the protection of plants.

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“…2`) [9]. Proinflammatory cytokines and even the gut microbiota can affect these events [10]. Optimally, DCs will process the captured tumor antigens and present them via their MHC class I and II molecules to stimulate T cells, which, together with DC costimulatory signals leads to priming and activation of effector T cells reactive to tumor cells (Fig.…”

Section: The Cancer-immunity Cyclementioning

confidence: 99%

Advances in personalized cancer immunotherapy

et al. 2016

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There are currently three major approaches to T cell-based cancer immunotherapy, namely, active vaccination, adoptive cell transfer therapy and immune checkpoint blockade. Recently, this latter approach has demonstrated remarkable clinical benefits, putting cancer immunotherapy under the spotlight. Better understanding of the dynamics of anti-tumor immune responses (the "Cancer-Immunity Cycle") is crucial for the further development of this form of treatment. Tumors employ multiple strategies to escape from anti-tumor immunity, some of which result from the selection of cancer cells with immunosuppressive activity by the process of cancer immunoediting. Apart from this selective process, anti-tumor immune responses can also be inhibited in multiple different ways which vary from patient to patient. This implies that cancer immunotherapy must be personalized to (1) identify the rate-limiting steps in any given patient, (2) identify and combine strategies to overcome these hurdles, and (3) proceed with the next round of the "Cancer-Immunity Cycle". Cancer cells have genetic alterations which can provide the immune system with targets by which to recognize and eradicate the tumor. Mutated proteins expressed exclusively in cancer cells and recognizable by the immune system are known as neoantigens. The development of next-generation sequencing technology has made it possible to determine the genetic landscape of human cancer and facilitated the utilization of genomic information to identify such candidate neoantigens in individual cancers. Future immunotherapies will need to be personalized in terms of the identification of both patient-specific immunosuppressive mechanisms and target neoantigens.

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Gut microbiome and anticancer immune response: really hot Sh*t!

Cited by 113 publications

References 135 publications

Anticancer metal drugs and immunogenic cell death

Anticancer metal drugs and immunogenic cell death

The microbiome of the leaf surface of Arabidopsis protects against a fungal pathogen

Advances in personalized cancer immunotherapy

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