Gut microbiome associated dysbiosis: Limited regimens and expanding horizons of phage therapy

Singha, Biplab; Rawat, Bhupendra Singh; Venkataraman, Ramya; Nair, Tripti; Rosenn, Eric H.; Soni, Vijay

doi:10.1016/j.amolm.2023.100029

Cited by 4 publications

(3 citation statements)

References 191 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Understanding the relationship between the GM and the developing brain of early infancy remains largely unknown since most previous research has primarily concentrated on adult subjects and has established connections using animal models. It is indisputable that the GM plays a vital role in neurodevelopment, as demonstrated using germ-free rodents [50,51,[53][54][55][56]. Immunological deficiencies and severe neurodevelopmental abnormalities ensue when the intestines of rodents fail to undergo typical colonization during their early developmental stages.…”

Section: Discussionmentioning

confidence: 99%

“…The GM undergoes a significant shift from birth until the age of three, becoming like an adult's GM. Developing a well-balanced GM during infancy is crucial since any imbalance might persist throughout adulthood, leading to dysbiosis [25,51,52]. Subsequently, many studies have focused on determining the factors that impact the composition of the GM in infants.…”

Section: Bibliometric Analysismentioning

confidence: 99%

See 1 more Smart Citation

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Tzitiridou-Chatzopoulou,

Kountouras,

Zournatzidou

2024

Children

View full text Add to dashboard Cite

Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to the development of new models and treatments targeting the gut–brain axis to mitigate the effects of various disorders. Related research suggests that interventions during the critical period from birth to three years old may yield the greatest benefits. Investigating the substantial link between the gut and brain during this crucial developmental phase raises fundamental issues about the role of microorganisms in human health and brain development. This underscores the importance of focusing on the prevention rather than the treatment of neurodevelopmental and neuropsychiatric disorders. The present review examines the gut microbiota from birth to age 3, with a particular focus on its potential relationship with neurodevelopment. This review emphasizes the immunological mechanisms underlying this relationship. Additionally, the study investigates the impact of the microbiome on cognitive development and neurobehavioral issues such as anxiety and autism. Importantly, it highlights the need to integrate mechanistic studies of animal models with epidemiological research across diverse cultures to better understand the role of a healthy microbiome in early life and the implications of dysbiosis. Furthermore, this review summarizes factors contributing to the transmission of gut microbiome-targeted therapies and their effects on neurodevelopment. Recent studies on environmental toxins known to impact neurodevelopment are also reviewed, exploring whether the microbiota may mitigate or modulate these effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Bibliometric Analysismentioning

confidence: 99%

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Tzitiridou-Chatzopoulou,

Kountouras,

Zournatzidou

2024

Children

View full text Add to dashboard Cite

show abstract

“…Se denomina disbiosis a una alteración en la estructura y función del microbioma del intestino, en la que la disbiosis intestinal propone que los individuos sean más propensos a obtener varias afecciones patológicas, tales como la enfermedad inflamatoria intestinal, la colitis ulcerosa, la diabetes, la enfermedad de Crohn, la enfermedad de Parkinson, la depresión, entre otros. A pesar de la evidente conexión entre distintas patologías y la disbiosis, en varias enfermedades aún no se ha establecido definitivamente si la disbiosis inicia el proceso de la enfermedad o si es una consecuencia de cambios en el sistema inmunológico, la alimentación y el metabolismo del paciente (Singha et al, 2023).…”

Section: Disbiosisunclassified

Microbiota intestinal y su relación con la enfermedad de Parkinson: Revisión actualizada para la práctica clínica

Argandoña Bravo,

Moreira Marcillo,

Alcívar Intriago

et al. 2024

LATAM

View full text Add to dashboard Cite

La Enfermedad de Parkinson (EP) es una enfermedad crónica y progresiva causada por la degeneración de las neuronas dopaminérgicas, cuya característica principal es la presencia de inclusiones citoplasmáticas intraneuronales de alfa-sinucleína o cuerpos de Lewy (CL), en el sistema nervioso central. No obstante, en los últimos años se ha logrado relacionar la disbiosis de la microbiota intestinal con la fisiopatología de la EP. Revisar desde los avances neurobiológicos cómo impacta la disbiosis en la microbiota intestinal para el desarrollo y progresión de la enfermedad de Parkinson. El estudio fue de tipo descriptivo, fundamentado en la recopilación, revisión y análisis de fuentes bibliográficas obtenidas a través de motores de búsqueda de información científica como Google Scholar y bases de datos como Dialnet, Science Direct, Pubmed, disponibles en inglés y español. Se encontró que en pacientes con EP hay un aumento de bacterias proinflamatorias. Así mismo se comprobó que la disbiosis puede aumentar la permeabilidad intestinal permitiendo el paso de toxinas bacterianas, así como la agregación de alfa-sinucleína. La alteración del microbiota intestinal forma parte de la fisiopatología de la enfermedad de Parkinson mediante la interacción eje - cerebro – intestino, lo que ha permitido determinar las consecuencias de los cambios químicos, como el aumento de la permeabilidad a nivel intestinal, la interferencia en las conexiones y los circuitos neuronales, asociado a inflamación.

show abstract

Editorial: Recent advances in understanding the role and mechanisms of gut microbiota in inflammatory bowel disease and irritable bowel syndrome

Yadegar,

Salahi-Niri,

Dai

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Gut microbiome associated dysbiosis: Limited regimens and expanding horizons of phage therapy

Cited by 4 publications

References 191 publications

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Microbiota intestinal y su relación con la enfermedad de Parkinson: Revisión actualizada para la práctica clínica

Editorial: Recent advances in understanding the role and mechanisms of gut microbiota in inflammatory bowel disease and irritable bowel syndrome

Contact Info

Product

Resources

About