Gut microbiome development along the colorectal adenoma–carcinoma sequence

Feng, Qiang; Liang, Suisha; Jia, Huijue; Stadlmayr, Andreas; Tang, Longqing; Lan, Zhou; Zhang, Dongya; Xia, Huihua; Xu, Xiaoying; Jie, Zhuye; Song, Lili; Li, Xiaoping; Li, Xin; Li, Junhua; Xiao, Liang; Huber-Schönauer, Ursula; Niederseer, David; Xu, Xun; Al‐Aama, Jumana Y.; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Arumugam, Manimozhiyan; Tilg, Herbert; Datz, Christian; Wang, Jun

doi:10.1038/ncomms7528

Cited by 1,149 publications

(1,139 citation statements)

References 63 publications

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“…Interestingly, early signs of dysbiosis have been reported at the adenoma stage, 15 and there is a significant increase in some species (such as Bacteroides) from healthy to advanced adenoma and from advanced adenoma to carcinoma. 13 However, these studies were not able to identify adenoma-associated bacterial communities predictive of cancer progression. This interesting point still remains a challenge for the future.…”

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confidence: 97%

“…Studies comparing bacteria associated with tumor tissue and with tumor-adjacent mucosa of CRC patients, and bacteria associated with the mucosa of healthy patients have demonstrated the existence of a dysbiotic microbiota associated with CRC. [13][14][15][16][17] Although it is still difficult to identify a "typical" dysbiotic microbiota associated with CRC, the abnormal abundance of certain species in colonic tissues of CRC patients has been found in numerous studies. 13,15 Thus, studies of CRC have observed a specific enrichment in Fusobacterium and Bacteroides, 13,15,17 bacteria that can potentially play a role in colorectal carcinogenesis.…”

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confidence: 99%

“…[13][14][15][16][17] Although it is still difficult to identify a "typical" dysbiotic microbiota associated with CRC, the abnormal abundance of certain species in colonic tissues of CRC patients has been found in numerous studies. 13,15 Thus, studies of CRC have observed a specific enrichment in Fusobacterium and Bacteroides, 13,15,17 bacteria that can potentially play a role in colorectal carcinogenesis. 18,19 In contrast, microbiota from healthy patients seems to be enriched in Bifidobacterium, 13 which are generally anti-inflammatory bacteria.…”

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confidence: 99%

“…13,15 Thus, studies of CRC have observed a specific enrichment in Fusobacterium and Bacteroides, 13,15,17 bacteria that can potentially play a role in colorectal carcinogenesis. 18,19 In contrast, microbiota from healthy patients seems to be enriched in Bifidobacterium, 13 which are generally anti-inflammatory bacteria. Interestingly, early signs of dysbiosis have been reported at the adenoma stage, 15 and there is a significant increase in some species (such as Bacteroides) from healthy to advanced adenoma and from advanced adenoma to carcinoma.…”

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Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments

et al. 2016

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Most cases of colorectal cancer (CRC) are sporadic, and numerous studies have suggested that gut microbiota may play a crucial role in CRC development. Escherichia coli is a member of the gut microbiota frequently associated with colorectal tumors. CRC-associated E. coli strains frequently harbor the pks genomic island. This genomic island is responsible for the synthesis of colibactin genotoxin, which increases tumor numbers in CRC mouse models. We recently showed that targeting ClbP, a key enzyme involved in colibactin synthesis, blocks the deleterious effect of this toxin in vitro and leads to a significant decrease in tumor numbers in vivo. Altogether, our results suggest that the personalized treatment of CRC should also take into consideration the bacteria associated with the tumor in order to limit their deleterious effects.

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Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments

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“…Qin et al recruited a cohort of 181 Chinese samples with 98 liver cirrhosis patients and 83 healthy individuals, and constructed a 2.7 M gut gene catalogue [27]. Feng et al collected and sequenced 156 fecal samples and constructed a non-redundant catalogue with about 3.5M genes [29]. The samples contain healthy controls and patients of advanced adenoma or carcinoma.…”

Section: [20] Img (Metagenome) Metagenomementioning

confidence: 99%

An overview of major metagenomic studies on human microbiomes in health and disease

Cui

Zhang

2016

Quant. Biol.

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Many microbes are important symbiotes of human. They form specific microbiota communities, participate in various kinds of biological processes of their host and thus deeply affect human health status. Metagenomic sequencing has been widely used in human microbiota study due to its capacity of studying all genetic materials in an environment as a whole without any extra need of isolation or cultivation of microorganisms. Many efforts have been made by researchers in this area trying to dig out interesting knowledge from various metagenome data. In this review, we go through some prominent studies in the metagenomic area. We summarize them into three categories, constructing taxonomy and gene reference, characterization of microbiome distribution patterns, and detection of microbiome alternations associated with specific human phenotypes or diseases. Some available data resources are also provided. This review can serve as an entrance to this exciting and rapidly developing field for researchers interested in human microbiomes.

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Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women

et al. 2019

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Importance: Colorectal cancer incidence and mortality among individuals under age 50 (young-onset CRC) are rising. The reasons for such increase are largely unknown, although the surging prevalence of obesity may be partially responsible. Objective: To investigate prospectively the association between obesity and weight gain since early adulthood with risk of young-onset CRC. Design: Prospective cohort. Setting: U.S.-based Nurses’ Health Study II. Participants: 85,256 women aged 25 to 44 years free of cancer and inflammatory bowel disease at enrollment were followed from 1989 to 2011. Validated anthropomorphic measures and lifestyle information were self-reported biennially. Exposures: Current body mass index (BMI), BMI at age 18, and weight gain since age 18. Main Outcomes and Measures: Relative risk (RR) for incident young-onset CRC. Results: We documented 114 cases of young-onset CRC during 1,196,452 person-years of follow-up. Compared to women with BMI 18.5–22.9 kg/m2, the multivariable RR was 1.37 [95% confidence interval (CI): 0.81–2.30] for overweight women (BMI 25–29.9 kg/m2) and 1.93 (95% CI: 1.15–3.25) for obese women (BMI ≥ 30 kg/m2). The RR for each 5 kg/m2 increment in BMI was 1.20 (95% CI: 1.05–1.38, P-trend=0.01). Similar associations were observed among women without a family history of CRC and without lower endoscopy within the past 10 years. Both BMI at age 18 and weight gain since age 18 contributed to this observation. Compared to women with BMI 18.5–20.9 kg/m2 at age 18, the RR of young-onset CRC was 1.63 (95% CI: 1.01–2.61) for women with BMI ≥ 23 kg/m2 at age 18 (P-trend=0.66). Similarly, compared to women who had gained < 5 kg or had lost weight, the RR of young-onset CRC was 2.15 (95% CI: 1.01–4.55) for women with ≥ 40 kg weight gain since age 18 (P-trend=0.007). Conclusion and Relevance: Obesity was associated with an increased risk of young-onset CRC among women. Further investigations among men and to elucidate underlying biological mechanisms are warranted.

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Gut microbiome development along the colorectal adenoma–carcinoma sequence

Cited by 1,149 publications

References 63 publications

Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments

Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments

An overview of major metagenomic studies on human microbiomes in health and disease

Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women

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