Gut microbiome dysbiosis in malnutrition

Chawla, Meenal; Gupta, Rashi; Das, Bhabatosh

doi:10.1016/bs.pmbts.2022.07.011

Cited by 10 publications

(4 citation statements)

References 105 publications

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“…Hence, our results align with the close relationship between periodontitis and AS. Moreover, as tooth loss is related to nutrient intake, it may contribute to the development of AS by contributing to malnutrition [ 37 ] or even dysbiosis of the gut microbiome [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Improved Oral Health Is Associated with a Lower Risk of Late Onset Ankylosing Spondylitis: A Nationwide Cohort Study

Chung,

Chang,

Park

et al. 2024

JCM

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Background: The aim of this study was to evaluate the association of oral health status and habits with the occurrence of ankylosing spondylitis (AS) in a nationwide population-based cohort in a longitudinal setting. Methods: A total of 2,415,963 individuals aged 40–79 years who underwent oral health examinations were included from the National Health Insurance Service-National Health Screening (NHIS-HEALS) cohort of Korea between 2003 and 2004. The occurrence of AS was analyzed according to the oral health status and oral hygiene habits. Results: Among 2,271,221 of the participants, AS occurred in 6366 (0.3%) participants over 16.7 years. The likelihood of AS was higher in participants who had periodontitis (hazard ratio [HR]: 1.33, 95% confidence interval [CI]: 1.20–1.46, p < 0.0001) and more missing teeth (HR: 1.68, 95% CI: 1.42–1.99, p < 0.0001). However, better oral hygiene habits such as frequent tooth brushing (HR: 0.77, 95% CI: 0.71–0.83, p < 0.0001) and a history of dental scaling within the last year (HR 0.88, 95% CI 0.82–0.95, p = 0.001) were associated with a lower occurrence of AS. Conclusions: Periodontitis and an increased number of missing teeth could be related to the occurrence of late-onset AS. Improved oral hygiene care may attenuate the likelihood of late-onset AS.

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Section: Discussionmentioning

confidence: 99%

Improved Oral Health Is Associated with a Lower Risk of Late Onset Ankylosing Spondylitis: A Nationwide Cohort Study

Chung,

Chang,

Park

et al. 2024

JCM

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“…Gut microbiota composition stabilizes during adulthood under healthy conditions but may undergo fundamental changes due to factors disturbing the healthy gut microbiota and leading to imbalanced gut microbiota or dysbiosis. The gut microbiota dysbiosis is an adverse physiological phenomenon that is associated with a decrease in the density of commensal bacteria against the presence of pathogens [ 55 ]. Hereof, dysbiosis is implicated in the onset and progression of several metabolic and inflammatory diseases [ 56 ].…”

Section: Gut Microbiota Dysbiosis and Dietmentioning

confidence: 99%

“…A mixture of prebiotics and probiotics are thought to elicit more potent clinical responses compared to their single biofunction [ 55 ]. Notably, the generalization of this idea to childhood malnutrition requires more investigations.…”

Section: Childhood Malnutrition Treatmentmentioning

confidence: 99%

Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

Zoghi,

Sadeghpour Heravi,

Nikniaz

et al. 2023

Engineering in Life Sciences

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Childhood malnutrition is a metabolic condition that affects the physical and mental well‐being of children and leads to resultant disorders in maturity. The development of childhood malnutrition is influenced by a number of physiological and environmental factors including metabolic stress, infections, diet, genetic variables, and gut microbiota. The imbalanced gut microbiota is one of the main environmental risk factors that significantly influence host physiology and childhood malnutrition progression. In this review, we have evaluated the gut microbiota association with undernutrition and overnutrition in children, and then the quantitative and qualitative significance of gut dysbiosis in order to reveal the impact of gut microbiota modification using probiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, and engineering biology methods as new therapeutic challenges in the management of disturbed energy homeostasis. Understanding the host–microbiota interaction and the remote regulation of other organs and pathways by gut microbiota can improve the effectiveness of new therapeutic approaches and mitigate the negative consequences of childhood malnutrition.

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“…Therefore, GM-targeted nutrition interventions have been proposed as a promising strategy to improve child nutritional outcomes. As such, in recent times, nutrition interventions, aside from enhancing growth, have sought to target GM dysbiosis by using prebiotics, probiotics, synbiotics, or specialized complementary feeds [ 3 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome-Targeted Nutrition Interventions and Growth among Children in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Addae,

Apprey,

Kwarteng

2024

Current Developments in Nutrition

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Gut microbiome dysbiosis in malnutrition

Cited by 10 publications

References 105 publications

Improved Oral Health Is Associated with a Lower Risk of Late Onset Ankylosing Spondylitis: A Nationwide Cohort Study

Improved Oral Health Is Associated with a Lower Risk of Late Onset Ankylosing Spondylitis: A Nationwide Cohort Study

Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

Gut Microbiome-Targeted Nutrition Interventions and Growth among Children in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

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