Gut microbiome in rheumatic diseases

Moiseev, Sergey; Рамеев, В.В.; Karovaikina, Ekaterina; Lysenko, Lidiа

doi:10.1136/annrheumdis-2019-216560

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…The faecal samples of SLE patients had an increased amount of sIgA-coated R. gnavus. Moreover, SLE patients with nephritis had an increased abundance of R. gnavus with increased serum IgG levels to its cell wall lipoglycan antigens [98,99] .…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Kandasamy,

Letchumanan,

Hong

et al. 2023

Prog Micobes Mol Biol

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Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. The increasing evidence of elevated R. gnavus abundance in various inflammatory conditions suggests its potential as a therapeutic target. Despite this, there are limited studies on treatment strategies targeting R. gnavus. This article provides a comprehensive overview of the association between R. gnavus and diverse inflammatory conditions, highlighting the need for further research to explore effective treatment options against this bacterium.

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Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Kandasamy,

Letchumanan,

Hong

et al. 2023

Prog Micobes Mol Biol

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“…The microbiota significantly influences the development of joint lesions in inflammatory diseases, including RA and osteoarthritis 22 , 23 . Furthermore, dysregulated faecal microbes are associated with a variety of autoimmune diseases, including psoriasis, RA, and other immune system diseases 24 , 25 . The faecal microbiota and RA are closely related.…”

Section: Introductionmentioning

confidence: 99%

Impact of humid climate on rheumatoid arthritis faecal microbiome and metabolites

Wang,

Zheng,

et al. 2023

Sci Rep

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Studies have shown that high humidity is a condition that aggravates the pain of rheumatoid arthritis (RA), but the relevant mechanism is controversial. Currently, there is a lack of experimental animal studies on high humidity as an adverse factor related to the pathogenesis of RA. We used healthy SD rats and collagen-induced arthritis (CIA) rats to investigate the effects of high humidity on arthritis. Integrated metabolomics analyses of faeces and 16S rRNA sequencing of the faecal microbiota were performed to comprehensively assess the diversity of the faecal microbiota and metabolites in healthy and CIA rats. In this study, high humidity aggravated arthritis in CIA rats, which manifested as articular cartilage lesions, increased arthritis scores, and an increase in proinflammatory cytokines. High humidity had a certain effect on the articular cartilage extent, arthritis score and proinflammatory cytokines of healthy rats as well. Furthermore, high humidity caused significant changes in faecal microbes and metabolites in both healthy and CIA rats. 16S rRNA sequencing of faecal samples showed that high humidity increased the amount of inflammation-related bacteria in healthy and CIA rats. Faecal metabolomics results showed that high humidity significantly altered the level of faecal metabolites in healthy rats and CIA rats, and the changes in biological functions were mainly related to the inflammatory response and oxidative stress. Combined analysis showed that there was a strong correlation between the faecal microbiota and faecal metabolites. High humidity is an adverse factor for the onset and development of RA, and its mechanism is related to the inflammatory response and oxidative stress. However, the question of how high humidity impacts RA pathogenesis needs to be further investigated.

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“…The structure of the healthy faecal microbiota can maintain immune balance and inhibit in ammatory responses. Dysregulated faecal microbes are associated with a variety of autoimmune diseases, including psoriasis, RA, and other immune system diseases [22,23]. The faecal microbiota and RA are closely related.…”

Section: Introductionmentioning

confidence: 99%

The mechanism of a humid climate on the joints of normal rats and collagen- induced arthritis rats: mutual effects on faecal metabolism and microbial diversity

Wang

Zheng

et al. 2022

Preprint

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BackgroundStudies have shown that high humidity is a condition that aggravates the pain of rheumatoid arthritis (RA), but the relevant mechanism is controversial. Currently, there is a lack of animal experimental studies on high humidity as an adverse factor related to the pathogenesis of RA.MethodsWe used healthy SD rats and collagen-induced arthritis (CIA) rats to investigate the effects of high humidity on arthritis in healthy rats and CIA rats. Integrated metabolomics analyses of faeces and 16S rRNA sequencing of the faecal microbiota were performed to comprehensively analyse the results and diversity of the faecal microbiota and metabolites in healthy rats and CIA rats.ResultsIn this study, high humidity aggravated arthritis in CIA rats, including articular cartilage lesions, arthritis scores, and proinflammatory cytokines. High humidity had a certain effect on articular cartilage extent, arthritis score and proinflammatory cytokines of healthy rats. Furthermore, high humidity caused significant changes in faecal microbes and faecal metabolites in healthy and CIA rats. Sequencing of the 16S rRNA unit in faecal samples showed that high humidity aggravated inflammation-related bacteria in healthy and CIA rats. Faecal metabolomics results showed that high humidity significantly altered faecal metabolites in healthy rats and CIA rats, and the changes in biological functions were mainly related to the inflammatory response and oxidative stress. Combined analysis showed that there was a strong correlation between the faecal microbiota and faecal metabolites.ConclusionHigh humidity is an adverse factor for the onset and development of RA, and its mechanism is related to the inflammatory response and oxidative stress. However, how high humidity leads to the pathogenesis of RA needs to be further determined.

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Gut microbiome in rheumatic diseases

Cited by 5 publications

References 11 publications

The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Impact of humid climate on rheumatoid arthritis faecal microbiome and metabolites

The mechanism of a humid climate on the joints of normal rats and collagen- induced arthritis rats: mutual effects on faecal metabolism and microbial diversity

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