Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease

Li, Ranxi; Yi, Xinzhu; Yang, Junhao; Zhu, Zhou; Wang, Yifei; Liu, Xiaomin; Huang, Xili; Wan, Yu; Fu, Xihua; Shu, Wen‐Sheng; Zhang, Wenjie; Wang, Zhang

doi:10.3389/fmicb.2022.916061

Cited by 18 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Note that all the records concerning HAV and HDV were excluded ( Figure 1 ). Among the 12 included studies from PubMed, 1 was about HEV infection( Wu et al., 2020 ), 4 were about HCV infection( Aly et al., 2016 ; Taylor et al., 2020 ; Sultan et al., 2021 ; Ali et al., 2023 ), and 7 were HBV-related liver disorders ( Wang et al., 2017 ; Liu et al., 2018 ; Liu et al., 2019 ; Ni et al., 2019 ; Chen et al., 2020 ; Zheng et al., 2020 ; Li et al., 2022 ). The remaining unpublished data was from BioProject and concerned HBV (BioProject accession number PRJEB32568).…”

Section: Resultsmentioning

confidence: 99%

“…The PCoA and NMDS analyses were conducted with PERMANOVA and ANOSIM, respectively, to evaluate the similarities in the gut microbiome composition among the groups in all the included studies. The PERMANOVA and ANOSIM results for the datasets of PRJEB32568 and PRJNA838083 ( Li et al., 2022 ) reporting four separate groups (HC, CHB, HBV-LC, and HBV-HCC) indicated that as HBV infection progressed, there were significant differences in species composition between the groups ( P < 0.01; Figures 7 , 8 ). The PERMANOVA results for the PRJNA558158 ( Chen et al., 2020 ) and PRJNA540574 ( Zheng et al., 2020 ) datasets showed the same trend ( P < 0.01; Figure 7 ).…”

Section: Resultsmentioning

confidence: 99%

“… The gut microbial beta diversity changed as HBV progressed based on PCoA analysis. The PCoA analysis showed that the gut microbiome composition was significantly different based on the PERMANOVA test in the datasets of PRJEB32568, PRJNA838083 ( Li et al., 2022 ), PRJNA558158 ( Chen et al., 2020 ), and PRJNA540574 ( Zheng et al., 2020 ). * P <0.05, ** P <0.01, *** P <0.001.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis

Yang

Mai

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundGut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully clarified.MethodsPubMed and BioProject databases were searched for studies about viral hepatitis disease and 16S rRNA gene sequencing of gut microbiota up to January 2023. With bioinformatics analyses, we explored changes in microbial diversity of viral hepatitis, screened out crucial bacteria and microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting risks for the occurrence and progression of viral hepatitis based on ROC analysis.ResultsOf the 1389 records identified, 13 studies met the inclusion criteria, with 950 individuals including 656 patient samples (HBV, n = 546; HCV, n = 86; HEV, n = 24) and 294 healthy controls. Gut microbial diversity is significantly decreased as the infection and progression of viral hepatitis. Alpha diversity and microbiota including Butyricimonas, Escherichia-Shigella, Lactobacillus, and Veillonella were identified as the potential microbial markers for predicting the risk of development of viral hepatitis (AUC>0.7). Microbial functions including tryptophan metabolism, fatty acid biosynthesis, lipopolysaccharide biosynthesis, and lipid metabolism related to the microbial community increased significantly as the development of viral hepatitis.ConclusionsThis study demonstrated comprehensively the gut microbiota characteristics in viral hepatitis, screened out crucial microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting the risk of viral hepatitis.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis

Yang

Mai

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Short-chain fatty acids, especially butyrate, produced by gut microbiota were reported to suppress inflammatory response and oxidative stress ( Hu et al, 2013 ). Besides, Monoglobus was enriched in health individuals, and its abundance was positively correlated with CD4+ T cell counts ( Li R. et al, 2022 ; Wang et al, 2022 ). CD4(+) T cells play crucial roles in adaptive immune response against pathogens ( Yang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic acid improves growth performance of weaned rabbits via modulating the intestinal epithelium functions and intestinal microbiota

Chen

Song

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

This study was conducted to investigate the impacts of chlorogenic acid (CGA) on growth performance, intestinal permeability, intestinal digestion and absorption-related enzyme activities, immune responses, antioxidant capacity and cecum microbial composition in weaned rabbits. One hundred and sixty weaned rabbits were allotted to four treatment groups and fed with a basal diet or a basal diet supplemented with 400, 800, or 1,600 mg/kg CGA, respectively. After a 35-d trial, rabbits on the 800 mg/kg CGA-supplemented group had higher (p < 0.05) ADG and lower (p < 0.05) F/G than those in control (CON) group. According to the result of growth performance, eight rabbits per group were randomly selected from the CON group and 800 mg/kg CGA group to collect serum, intestinal tissue samples and cecum chyme samples. Results showed that compared with the CON group, supplementation with 800 mg/kg CGA decreased (p < 0.05) levels of D-lactate, diamine oxidase, IL-1β, IL-6, and malondialdehyde (MDA), and increased IL-10 concentration in the serum; increased (p < 0.05) jejunal ratio of villus height to crypt depth, enhanced (p < 0.05) activities of maltase and sucrase, increased (p < 0.05) concentrations of IL-10, T-AOC, MHCII and transforming growth factor-α, and decreased (p < 0.05) levels of TNF-α and MDA in the jejunum of weaned rabbits. In addition, results of high-throughput sequencing showed that CGA supplementation elevated (p < 0.05) microbial diversity and richness, and increased (p < 0.05) the abundances of butyrate-producing bacteria (including genera V9D2013_group, Monoglobus, Papillibacter, UCG-005, and Ruminococcus). These results indicated that dietary supplementation with 800 mg/kg CGA could improve the growth performance of weaned rabbits by enhancing intestinal structural integrity, improving the intestinal epithelium functions, and modulating the composition and diversity of gut microbiota.

show abstract

“…However, the causative relation between the microbiome and HBV replication is very complicated, and has not yet been adequately clarified. Briefly, some studies have shown that HBV infection alters the microbiome [ 34 , 35 ], whereas others have shown that, conversely, the gut microbiome can affect HBV replication and disease progression. In mice, fecal transplant can significantly alter HBV replication and disease progression [ 36 ].…”

Section: Interactions Between Hbv Infection Metabolism and Hormonesmentioning

confidence: 99%

Many Ways to Communicate—Crosstalk between the HBV-Infected Cell and Its Environment

2022

View full text Add to dashboard Cite

Chronic infection with the hepatitis B virus (HBV) affects an estimated 257 million people worldwide and can lead to liver diseases such as cirrhosis and liver cancer. Viral replication is generally considered not to be cytopathic, and although some HBV proteins may have direct carcinogenic effects, the majority of HBV infection-related disease is related to chronic inflammation resulting from disrupted antiviral responses and aberrant innate immune reactions. Like all cells, healthy and HBV-infected cells communicate with each other, as well as with other cell types, such as innate and adaptive immune cells. They do so by both interacting directly and by secreting factors into their environment. Such factors may be small molecules, such as metabolites, single viral proteins or host proteins, but can also be more complex, such as virions, protein complexes, and extracellular vesicles. The latter are small, membrane-enclosed vesicles that are exchanged between cells, and have recently gained a lot of attention for their potential to mediate complex communication and their potential for therapeutic repurposing. Here, we review how HBV infection affects the communication between HBV-infected cells and cells in their environment. We discuss the impact of these interactions on viral persistence in chronic infection, as well as their relation to HBV infection-related pathology.

show abstract

Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease

Cited by 18 publications

References 47 publications

Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis

Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis

Chlorogenic acid improves growth performance of weaned rabbits via modulating the intestinal epithelium functions and intestinal microbiota

Many Ways to Communicate—Crosstalk between the HBV-Infected Cell and Its Environment

Contact Info

Product

Resources

About