Gut microbiota: A new target of traditional Chinese medicine for insomnia

Feng, Wanying; Yang, Zhihua; Liu, Yangxi; Chen, Rui; Song, Zhihui; Pan, Guiyun; Zhang, Yuhang; Guo, Zehui; Ding, Xinya; Chen, Lu; Wáng, Yì

doi:10.1016/j.biopha.2023.114344

Cited by 32 publications

(15 citation statements)

References 101 publications

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“…The above results preliminarily indicated that the efficacy of ICA combined with CUR in treating PCa was significantly better than when ICA and CUR were used alone. The gut microbiota metabolizes the active ingredients of traditional Chinese medicine, which can help maintain intestinal health by balancing the microbial population [ 37 ]. Researchers have found that ICA is easily metabolized by gut microbiota or enzymes after oral administration [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Xu,

Li,

Liu

et al. 2024

J Exp Clin Cancer Res

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Background Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) and curcumol (CUR) induced autophagy and ferroptosis in PCa cells, and altered lipid metabolism. We aimed to further explore the effects of the combination of ICA and CUR on gut microbiota, metabolism, and immunity in PCa. Methods A mouse subcutaneous RM-1 cell tumor model was established. 16 S rRNA sequencing was performed to detect changes in fecal gut microbiota. SCFAs in mouse feces, and the effect of ICA-CUR on T-cell immunity, IGFBP2, and DNMT1 were examined. Fecal microbiota transplantation (FMT) was conducted to explore the mechanism of ICA-CUR. Si-IGFBP2 and si/oe-DNMT1 were transfected into RM-1 and DU145 cells, and the cells were treated with ICA-CUR to investigate the mechanism of ICA-CUR on PCa development. Results After treatment with ICA-CUR, there was a decrease in tumor volume and weight, accompanied by changes in gut microbiota. ICA-CUR affected SCFAs and DNMT1/IGFBP2/EGFR/STAT3/PD-L1 pathway. ICA-CUR increased the positive rates of CD3+CD8+IFN-γ, CD3+CD8+Ki67 cells, and the levels of IFN-γ and IFN-α in the serum. After FMT (with donors from the ICA-CUR group), tumor volume and weight were decreased. SCFAs promote tumor development and the expression of IGFBP2. In vitro, DNMT1/IGFBP2 promotes cell migration and proliferation. ICA-CUR inhibits the expression of DNMT1/IGFBP2. Conclusions ICA-CUR mediates the interaction between gut microbiota and the DNMT1/IGFBP2 axis to inhibit the progression of PCa by regulating immune response and metabolism, suggesting a potential therapeutic strategy for PCa.

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Section: Resultsmentioning

confidence: 99%

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Xu,

Li,

Liu

et al. 2024

J Exp Clin Cancer Res

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“…The gut microbiota of the human body and its living intestinal environment constitute intestinal microecology, which is the main and most complex microecology of the human body, and the gut microbiota occupies the core position of intestinal microecology. According to the relationship between gut microbiota and host, gut microbiota can be divided into beneficial bacteria, neutral bacteria and harmful bacteria ( Yang et al, 2022c ; Feng et al, 2023 ). The composition of the gut microbiota is dynamic, which has some individual differences, and is related to the environment, age, diet, disease, drugs, and genetics ( Human Microbiome Project, 2012 ).…”

Section: The Relationship Between Tcm and Intestinal Microecologymentioning

confidence: 99%

Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension

et al. 2023

Self Cite

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Hypertension has become one of the major public health problems in the world. At present, the pathogenesis of hypertension has still not been completely elucidated. In recent years, an increasing evidence shows that intestinal microecology is closely related to hypertension, which provides a new thinking for the prevention and treatment of hypertension. Traditional Chinese medicine (TCM) has unique advantages in the treatment of hypertension. Taking intestinal microecology as the target, it is possible to interpreting the scientific connotation of TCM prevention and treatment of hypertension by updating the treatment concept of hypertension, so as to improve the therapeutic effect. In our study, the clinical evidence for TCM treatment of hypertension was systematicly summarized. And the relationship among TCM, intestinal microecology and hypertension was analyzed. In addition, the methods by which TCM regulates intestinal microecology to prevent and treat hypertension were presented, to provide new research ideas for prevention and treatment of hypertension.

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“…The disease is closely related to heart, liver, spleen and kidney, kidney water cannot nourish the heart Yin, temper blood are insufficient, not enough to nourish the heart, so the heart-kidney discord is one of the important pathogenesis. [8] According to the above theory, this type of insomnia should be based on conditioning, so that the heart fire drops, the kidney water rises, the water fire is balanced, and the balance of Yin and Yang of the human body can be maintained. [9] Ningshen mixture originated from the experience of Shanghai famous old Chinese medicine director Ye Jinghua, set up the method of benefiting the kidney and nourishing the heart to achieve the aim of Yin and Yang balance.…”

Section: Introductionmentioning

confidence: 99%

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

Cai,

Zhang,

et al. 2024

Medicine

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Background: In recent years, the incidence of menopause insomnia has gradually increased, seriously affecting women's physical and mental health. Methods: Total 82 climacteric insomnia patients received from January 2021 to January 2023 were divided into 2 groups at random. In control group, 41 cases received conventional Western medicine, and in study group, 41 cases received acupuncture combined with Ningshen mixture. Clinical effectiveness of both groups was compared, neurotransmitter levels, TCM syndrome integral and Pittsburgh Sleep Quality Index (PSQI) were assessed in both groups. Meanwhile, the recurrence rate and safety were evaluated in 2 groups. Results: The curative effect in study group was better than that in control group (P < .05). After treatment, the expressions of 5-hydroxytryptamine and β-endorphin (β-EP) in study group were higher than control group (P < .05); TCM syndrome scores and PSQI scores in study group were lower than control group (P < .05). The total recurrence rate in study group was obviously lower than control group at 3 months after treatment (P < .05). There were no serious adverse reactions in both group, and no distinct difference between 2 groups was found (P > .05). Conclusion: Acupuncture united with Ningshen mixture has a significant therapeutic effect and high safety in climacteric insomnia patients. It can effectively improve the neurotransmitter levels, clinical symptoms and sleep quality, and reduce the recurrence rate of climacteric insomnia patients, which has high clinical application value and is worthy of clinical promotion.

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Gut microbiota: A new target of traditional Chinese medicine for insomnia

Cited by 32 publications

References 101 publications

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

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