Gut Microbiota: A Potential Target for Cancer Interventions

Zhou, Hu; Yuan, Yuan; Wang, Haorun; Xiang, Wei; Li, Shenjie; Haowen, Zheng; Wen, Yao; Yang, Moon-Sik; Chen, Ligang; Zhou, Jie

doi:10.2147/cmar.s328249

Cited by 18 publications

(14 citation statements)

References 144 publications

(207 reference statements)

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“…The gut microbiota impacts probably the manifestation and development of amebiasis through immunity ( Burgess and Petri, 2016 ; Watanabe et al, 2017 ; Burgess et al, 2020 ), metabolism ( Nakada-Tsukui and Nozaki, 2016 ), direct interaction with the parasite ( Bracha and Mirelman, 1984 ; Padilla-Vaca et al, 1999 ; Galvan-Moroyoqui et al, 2008 ; Varet et al, 2018 ), metabolites that promotes stress resistance in the parasite ( Shaulov et al, 2018 ; Nagaraja et al, 2021 ) and modulate epigenetic functions (this review). Fine-tuning the gut microbiota through diet or probiotics has been considered as a possible strategy to improve the efficacy and decrease the toxicity of treatment against cancer (for a recent review see ( Zhou et al, 2021 )). The same strategy has been considered for the prevention of amebiasis ( Nagaraja and Ankri, 2019 ; Ankri, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?

Sarid

Ankri

2022

Front. Cell Dev. Biol.

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The unicellular parasite Entamoeba histolytica inhabits the human gut. It has to adapt to a complex environment that consists of the host microbiota, nutritional stress, oxidative stress, and nitrosative stress. Adaptation to this complex environment is vital for the survival of this parasite. Studies have shown that the host microbiota shapes virulence and stress adaptation in E. histolytica. Increasing evidence suggests that metabolites from the microbiota mediate communication between the parasite and microbiota. In this review, we discuss the bacterial metabolites that regulate epigenetic processes in E. histolytica and the implications that this knowledge may have for the development of new anti-amebic strategies.

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Section: Discussionmentioning

confidence: 99%

Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?

Sarid

Ankri

2022

Front. Cell Dev. Biol.

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“…Therefore, it has been proposed that research should focus on developing personalized interventions adapted to each patient’s condition and microbiota characteristics. For instance, as microbiota may synergize with some drugs, particularly anti-cancer compounds, these drugs could be combined with interventions to restore the proper microbiota functioning (e.g., probiotics, fecal transplantation, metabolites) [ 49 , 50 ]. In the near future, predictive tests of the patients’ response to a given treatment may be developed based on their microbiota analysis.…”

Section: Gut Microbiota In Health and Diseasementioning

confidence: 99%

The Nutrition-Microbiota-Physical Activity Triad: An Inspiring New Concept for Health and Sports Performance

Barnich

Koechlin-Ramonatxo

2022

Nutrients

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The human gut microbiota is currently the focus of converging interest in many diseases and sports performance. This review presents gut microbiota as a real “orchestra conductor” in the host’s physio(patho)logy due to its implications in many aspects of health and disease. Reciprocally, gut microbiota composition and activity are influenced by many different factors, such as diet and physical activity. Literature data have shown that macro- and micro-nutrients influence gut microbiota composition. Cumulative data indicate that gut bacteria are sensitive to modulation by physical activity, as shown by studies using training and hypoactivity models. Sports performance studies have also presented interesting and promising results. Therefore, gut microbiota could be considered a “pivotal” organ for health and sports performance, leading to a new concept: the nutrition-microbiota-physical activity triad. The next challenge for the scientific and medical communities is to test this concept in clinical studies. The long-term aim is to find the best combination of the three elements of this triad to optimize treatments, delay disease onset, or enhance sports performance. The many possibilities offered by biotic supplementation and training modalities open different avenues for future research.

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“…Evidence has corroborated that the alteration in the gut microbiome in the early stages of CRC may be employed to diagnose and detect individuals at risk of presenting colorectal adenoma. These changes can also affect the effectiveness of conventional therapies such as radiotherapy and chemotherapy ( Zhou et al, 2021 ). Therefore, several studies, have been conducted to determine specific microbial patterns or significant changes in the intestinal microbial community of patients and healthy individuals, using the molecular study of faecal microbiota, in order to find a suitable biomarker for CRC .…”

Section: The Ecological Diversity Of Actinobacteria and Their Nps Aga...mentioning

confidence: 99%

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

et al. 2022

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Colorectal cancer (CRC) is a common, and deadly disease. Despite the improved knowledge on CRC heterogeneity and advances in the medical sciences, there is still an urgent need to cope with the challenges and side effects of common treatments for the disease. Natural products (NPs) have always been of interest for the development of new medicines. Actinobacteria are known to be prolific producers of a wide range of bioactive NPs, and scientific evidence highlights their important protective role against CRC. This review is a holistic picture on actinobacter-derived cytotoxic compounds against CRC that provides a good perspective for drug development and design in near future. This review also describes the chemical structure of 232 NPs presenting anti-CRC activity with the being majority of quinones, lactones, alkaloids, peptides, and glycosides. The study reveals that most of these NPs are derived from marine actinobacteria followed by terrestrial and endophytic actinobacteria, respectively. They are predominantly produced by Streptomyces, Micromonospors, Saliniospors and Actinomadura, respectively, in which Streptomyces, as the predominant contributor generating over 76% of compounds exclusively. Besides it provides a valuable snapshot of the chemical structure-activity relationship of compounds, highlighting the presence or absence of some specific atoms and chemical units in the structure of compounds can greatly influence their biological activities. To the best of our knowledge, this is the first comprehensive review on natural actinobacterial compounds affecting different types of CRC. Our study reveals that the high diversity of actinobacterial strains and their NPs derivatives, described here provides a new perspective and direction for the production of new anti-CRC drugs and paves the way to innovation for drugs discovery in the future. The knowledge obtain from this review can help us to understand the pivotal application of actinobacteria in future drugs development.

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Gut Microbiota: A Potential Target for Cancer Interventions

Cited by 18 publications

References 144 publications

Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?

Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?

The Nutrition-Microbiota-Physical Activity Triad: An Inspiring New Concept for Health and Sports Performance

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

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