2020
DOI: 10.3390/vaccines8020285
|View full text |Cite
|
Sign up to set email alerts
|

Gut Microbiota Abrogates Anti-α-Gal IgA Response in Lungs and Protects against Experimental Aspergillus Infection in Poultry

Abstract: Naturally occurring human antibodies (Abs) of the isotypes IgM and IgG and reactive to the galactose-α-1,3-galactose (α-Gal) epitope are associated with protection against infectious diseases, caused by pathogens expressing the glycan. Gut microbiota bacteria expressing α-Gal regulate the immune response to this glycan in animals lacking endogenous α-Gal. Here, we asked whether the production of anti-α-Gal Abs in response to microbiota stimulation in birds, confers protection against infection by Aspergillus f… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
42
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

4
4

Authors

Journals

citations
Cited by 31 publications
(44 citation statements)
references
References 67 publications
2
42
0
Order By: Relevance
“…Finally, the higher representation of antiα-Gal IgA antibodies in ICU patients may be associated with the inflammatory response observed in these cases. In accordance with these results, it was recently shown in endogenous α-Gal-negative turkeys that treatment with probiotic bacteria with high α-Gal content results in protection against aspergillosis through reduction by still unknown mechanisms in the proinflammatory anti-α-Gal IgA response in the lungs [27]. Based on the fact that natural antibodies against α-Gal are produced in response to bacteria with this modification in the microbiota [10], our hypothesis is that the dysbacteriosis observed in COVID-19 patients [28] translates into a reduction in total anti-α-Gal antibody titers and alteration of anti-α-Gal antibody isotype composition due to the reduction in the microbiota of α-Gal-containing commensal bacteria and other still uncharacterized mechanisms ( Figure 5).…”
Section: Discussionsupporting
confidence: 75%
See 1 more Smart Citation
“…Finally, the higher representation of antiα-Gal IgA antibodies in ICU patients may be associated with the inflammatory response observed in these cases. In accordance with these results, it was recently shown in endogenous α-Gal-negative turkeys that treatment with probiotic bacteria with high α-Gal content results in protection against aspergillosis through reduction by still unknown mechanisms in the proinflammatory anti-α-Gal IgA response in the lungs [27]. Based on the fact that natural antibodies against α-Gal are produced in response to bacteria with this modification in the microbiota [10], our hypothesis is that the dysbacteriosis observed in COVID-19 patients [28] translates into a reduction in total anti-α-Gal antibody titers and alteration of anti-α-Gal antibody isotype composition due to the reduction in the microbiota of α-Gal-containing commensal bacteria and other still uncharacterized mechanisms ( Figure 5).…”
Section: Discussionsupporting
confidence: 75%
“…Finally, the higher representation of anti‐α‐Gal IgA antibodies in ICU patients may be associated with the inflammatory response observed in these cases. In accordance with these results, it was recently shown in endogenous α‐Gal‐negative turkeys that treatment with probiotic bacteria with high α‐Gal content results in protection against aspergillosis through reduction by still unknown mechanisms in the pro‐inflammatory anti‐α‐Gal IgA response in the lungs 29 …”
Section: Discussionsupporting
confidence: 72%
“…The synthesis of the glycan Galα1-3Galβ1-4GlcNAc-R (α-Gal) by the enzyme α-1,3-galactosyltransferase occurs in bacteria [ 10 , 11 , 12 , 13 ], fungi [ 14 , 15 , 16 ], and noncatarrhine mammals [ 17 ], but prokaryotic and eukaryotic α-1,3-galactosyltransferase genes and proteins share little structural homology [ 18 , 19 , 20 ]. Humans, old world monkeys and apes evolved with the inability to synthesize α-Gal, which resulted in the capacity to produce anti-α-Gal IgM/IgG antibodies with a protective activity against pathogenic viruses (e.g., HIV), bacteria (e.g., Mycobacterium ) and parasites (e.g., Plasmodium ), containing this modification on membrane proteins [ 21 , 22 , 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…Vaccination strategies have been attempted in birds but with inconsistent results [ 115 , 126 , 249 , 250 ].…”
Section: Preventionmentioning
confidence: 99%