Gut microbiota alterations associated with antibody-mediated rejection after kidney transplantation

Wang, Junpeng; Li, Xin; Wu, Xiaoqiang; Wang, Zhiwei; Zhang, Chan; Cao, Guanghui; Liu, Shun; Yan, Tianzhong

doi:10.1007/s00253-020-11069-x

Cited by 21 publications

(32 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a very recent study, Wang et al 36 characterised the gut microbiota possibly associated with antibody-mediated rejection (AMR) in 24 kidney transplant recipients with AMR. The study showed the gut microbial community of kidney transplant recipients with AMR was different from controls and that Clostridiales is a potential marker to distinguish recipients with AMR.…”

Section: Dysbiosis and Acute Rejectionmentioning

confidence: 99%

The Microbiota and Kidney Transplantation: Influence on the Graft

Salvadori

Tsalouchos

2021

EMJ Urol

View full text Add to dashboard Cite

The gut microbial community may be associated with complications after kidney transplantation. The indigenous microbiota has a significant and protective function that influences the transplant recipient response. Genetic or environmental factors may modify the indigenous microbiota and pathobionts appear. In this condition, several disturbances of the kidney graft may be observed. These include acute rejection, infection, diarrhoea, disturbance in the induction of tolerance, and modification of immunosuppressive drug metabolism. Recently, the use of prebiotics, probiotics, and synbiotics has been demonstrated to be effective in normalising these conditions and in restoring the generation of the normal indigenous microbiota. An improved understanding of the function and composition of the indigenous microbiota may help in finding further solutions to stabilise the microbiota after kidney transplantation.

show abstract

Section: Dysbiosis and Acute Rejectionmentioning

confidence: 99%

The Microbiota and Kidney Transplantation: Influence on the Graft

Salvadori

Tsalouchos

2021

EMJ Urol

View full text Add to dashboard Cite

show abstract

“…Given that inflammation is an essential process contributing to CAD, it is reasonable to speculate that the lower level of SBAs in the CAD2 group directly weakened the anti-inflammatory effect of SBAs and thus participates in the pathogenesis of CAD in KTRs. In addition, a series of studies have demonstrated that BAs are potent antimicrobials that control microbial diversity in host intestines, dysbiosis of which triggered signals regulating inflammation and were significantly associated with kidney graft outcomes [ 12 , 25 – 27 ]. Therefore, the downregulation of SBAs observed in the current study may have promoted the progression of CAD through indirect regulation of gut microbiota in KTRs.…”

Section: Discussionmentioning

confidence: 99%

Altered Serum Bile Acid Profile Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients

Zhang²,

Dai

et al. 2022

Ann Transplant

View full text Add to dashboard Cite

Background Chronic allograft dysfunction (CAD) is the leading cause of graft loss among kidney transplant recipients (KTRs). Bile acids (BAs) play an important role in regulating inflammatory process, which is the major contributor to the development of CAD. The aim of this study was to evaluate the association between BAs metabolic dysregulation and CAD in KTRs. Material/Methods Fifteen serum BA species were determined in 43 healthy controls (HCs) and 131 KTRs by UPLC-MS/MS. KTRs were grouped into stable renal function (STA) and CAD1 and CAD2 groups based on eGFR levels. Circulating CYP7A1 , CYP7B1 , CYP27A1, and SLCO2B1 mRNA levels were determined by RT-PCR. Results Total BA concentrations were comparable among the 4 groups. However, KTRs showed significantly different BAs profiling compared to HCs. KTRs with severe CAD (CAD2) had significantly lower unconjugated BAs and secondary BAs (SBAs) compared to the other 3 groups. KTRs had significantly lower SBAs/primary BAs (PBAs) ratios than HCs, which were comparable among the 3 KTR groups. Conjugated/unconjugated BAs ratios increased significantly with the deterioration of allograft function, which was further confirmed by correlation analysis. Differential correlation network analysis revealed that perturbations in intraclass and interclass BA coregulation existed during CAD progression. Moreover, relative gene expressions of CYP7B1 and CYP27A1 were positively correlated with eGFR. Conclusions BA species profiling, but not total BA concentrations, was significantly altered in KTRs with CAD. The shifts from unconjugated BAs toward conjugated BAs, SBAs toward PBAs, and distinct pairwise BAs coregulation patterns were the main characteristics of KTRs with CAD.

show abstract

“…The authors of the study also noted that the specific pre-transplant microbiota differences in certain patients were indicative of adverse post-transplantation consequences such as infections and even transplant rejection, thus corroborating the diagnostic, clinical, and therapeutic value of patient microbiota analyses ( 175 ). Studies exploring how the gut and, consequently, fecal microbiota could provide nephrologists with a treasure trove of actionable data points, enabling improved allograft health monitoring and maintenance, have also been reported ( 176 , 177 ). Reports exploring the urinary microbiota in the context of renal transplantation have also yielded comparable insights ( 178 , 179 ).…”

Section: Renal Transplantationmentioning

confidence: 99%

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Sen

Thummer

2022

Front. Immunol.

View full text Add to dashboard Cite

The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interactions between the residents of the various human microbiotas and the human body. Since the gut microbiota is the densest, most popular, and most studied human microbiota, the impact of other human microbiotas such as the oral, lung, urinary, and genital microbiotas is often overshadowed. However, these microbiotas also provide critical and unique insights pertaining to transplantation success, rejection risk, and overall host health, across multiple different transplantation scenarios. Organ transplantation as well as the pre-, peri-, and post-transplant pharmacological regimens patients undergo is known to adversely impact the microbiotas, thereby increasing the risk of adverse patient outcomes. Over the past decade, holistic approaches to post-transplant patient care such as the administration of clinical and dietary interventions aiming at restoring deranged microbiota community structures have been gaining momentum. Examples of these include prebiotic and probiotic administration, fecal microbial transplantation, and bacteriophage-mediated multidrug-resistant bacterial decolonization. This review will discuss these perspectives and explore the role of different human microbiotas in the context of various transplantation scenarios.

show abstract

Gut microbiota alterations associated with antibody-mediated rejection after kidney transplantation

Cited by 21 publications

References 51 publications

The Microbiota and Kidney Transplantation: Influence on the Graft

The Microbiota and Kidney Transplantation: Influence on the Graft

Altered Serum Bile Acid Profile Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Contact Info

Product

Resources

About