Gut microbiota and acne: A Mendelian randomization study

Abstract

BackgroundPrior observational studies have identified a relationship between the composition of gut microbiota and the onset of acne. To ascertain the causal relationship underlying this association, we adopted the Mendelian randomization (MR) method, which offers a powerful approach to causal inference.MethodsSummary statistics on gut microbiota and acne were obtained from the MiBioGen and FinnGen consortium, respectively. The causal relationship was assessed using multiple methods in a two‐sample framework, including MR Egger, weighted median, inverse variance weighted (IVW), and weighted mode. Furthermore, the heterogeneity and horizontal pleiotropy analyses were conducted, along with the leave‐one‐out method.ResultsThe IVW estimation indicated that Allisonella (odds ratio [OR] = 1.42, 95% confidence interval [CI] = 1.18–1.70, p = 0.0002) and Bacteroides (OR = 2.25, 95% CI = 1.48–3.42, p = 0.0001) have adverse effects on acne. By contrast, Ruminococcus torques group (OR = 0.41, 95% CI = 0.25–0.65, p = 0.0002) showed a beneficial effect on acne. In addition, Candidatus soleaferrea (OR = 0.75, 95% CI = 0.60–0.95, p = 0.0149), Eubacterium coprostanoligenes group (OR = 0.67, 95% CI = 0.47–0.95, p = 0.0230), Fusicatenibacter (OR = 0.71, 95% CI = 0.52–0.97, p = 0.02897), and Lactobacillus (OR = 0.72, 95% CI = 0.58–0.90, p = 0.0046) showed suggestive associations with acne.ConclusionThe present investigation suggests a causal effect of gut microbiota on acne.

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

“…Furthermore, four other types of gut microflora, including those from the Candidatus soleaferrea group and Eubacterium coprostanoligenes showed suggestive protective effects against acne. In contrast, Allisonella and Bacteroides were responsible for exacerbating acne [122].…”

Gut microbiota, skin microbiota, and alopecia areata: A Mendelian randomization study

“…This axis suggests a close relationship between gut health and skin health, indicating that the microbiota and metabolites in the gut can affect skin conditions through various pathways 9 . Research has already demonstrated that certain gut microbiota are closely associated with facial skin aging and acne 10,11 . Additionally, studies have shown that inflammatory bowel disease and psoriasis may influence each other through shared genetic mechanisms and tissue expression pathways 12 .…”

“…9 Research has already demonstrated that certain gut microbiota are closely associated with facial skin aging and acne. 10,11 Additionally, studies have shown that inflammatory bowel disease and psoriasis may influence each other through shared genetic mechanisms and tissue expression pathways. 12 However, the relationship between the gut microbiota and the skin microbiota still requires further investigation.…”

Correlation between cigarette smoking and alcohol consumption and Rosacea: A two‐sample Mendelian randomization study

“…The relationship between alcohol consumption and Rosacea is also debated, with some studies suggesting an association, 8,18 while others find no significant difference 19 . Studies have shown that cigarette smoking and drinking can affect the human microbiome, 20,21 and changes in skin microbiome and intestinal microbiome are closely related to the occurrence and development of Rosacea 22–24 . Effective treatment interventions targeting disturbed skin and gut microbiota in Rosacea patients have been documented 25 .…”

“… 19 Studies have shown that cigarette smoking and drinking can affect the human microbiome, 20 , 21 and changes in skin microbiome and intestinal microbiome are closely related to the occurrence and development of Rosacea. 22 , 23 , 24 Effective treatment interventions targeting disturbed skin and gut microbiota in Rosacea patients have been documented. 25 However, the unclear pathophysiological mechanisms of Rosacea underscore the importance of understanding its risk factors for preventive strategies and further exploration of its underlying mechanisms.…”