Gut Microbiota and Aging

Kashtanova, Daria A.; Ткачева, О. Н.; Стражеско, И. Д.; Dudinskaya, Ekaterina N.; Kotovskaya, Yu. V.; Popenko, Anna; Tyaht, A. V.; Alexeev, Dmitry

doi:10.1007/978-3-030-24970-0_17

Cited by 2 publications

(1 citation statement)

References 90 publications

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“…Critically, changes to the gut microbiota in the older will rush the beginning of dysbiosis and increment the commonness of pathogenic species in the intestinal microbial synthesis, which has been connected to raised degrees of the foundational support of provocative markers (IL-6, IL-8, TNF-α, and CRP). The connection between gut dysbiosis and malignant growth is in this way not restricted to a direct pathogenic pretended by explicit microorganisms on the intestinal epithelium, yet additionally to general environment insanity that has foundational outcomes through provocative pathways [44][45][46][47][48][49][50][51].…”

Section: Cellularmentioning

confidence: 99%

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Rahman

Islam

Mim

et al. 2022

Journal of Nanomaterials

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Cancer is a fatal disorder that affects people across the globe, yet existing therapeutics are ineffective. The development of submicrometer transport for optimizing the biodistribution of systemically provided medications is the focus of nanomedicine. Nanoparticle- (NP-) based treatments may enable the development of novel therapeutic approaches to combat this deadly disorder. In multifunctional, multimodal imaging, and drug delivery carriers, NPs generally play a major role. They have emerged as potential strategies for the invention of innovative therapeutic procedures in the last decade. The exponential growth of nanotechnologies in recent years has increased public awareness of the application of these innovative therapeutic approaches. Many tumor-targeted nanomedicines have been studied in cancer therapy, and there is clear evidence for a significant improvement in the therapeutic index of antineoplastic drugs. Age-related factors such as metabolic and physiological alterations in old age and inadequate animal models are currently understudied in nanomedicine and pharmacology. This review highlighted the most important targeting approaches, as well as public awareness, therapeutic advancements, and future prospects in age-related metabolic variations, and tumor-targeted nanomedicine studies.

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Section: Cellularmentioning

confidence: 99%

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Rahman

Islam

Mim

et al. 2022

Journal of Nanomaterials

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Active longevity: long-term clinical observation

Жданов

Khabibullin

Khammatova

et al. 2021

Rossiiskii zhurnal geriatricheskoi meditsiny

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Objective. The work is aimed to analyze the biochemical and lipid blood profile of patient Z and to evaluate the effect of a long-term garlic (Allium sativum L.) — based diet on aging-associated processes and slowing down pathological processes in heart-vessels system. Materials and methods. Blood profiles of the patient Z are studied which represents seventythree years old physically active man with intellectual professional activity who played lawn tennis twice a week for the 45 years and followed a consistent vegetarian diet without any meat and milk products (for 32 years), and a garlic-based diet for the last 11 years. The garlic diet represents uptake of one head of raw garlic every day orally (totally 25–30 g, e.g., 1 g of raw garlic per 3 kg of body weight 5–6 days a week) for 11 years. General, biochemical and lipid blood tests were examined during 15 years. Results. Laboratory blood tests of 2003 are testified the ill-being at the level of lipid profile and heart-vessels system as a result of pathological conditions and aging. As a result of garlic intake starting from 2007, blood biochemical profile is started to testify that negative changes at the patient Z’s organism are slowed, levels of cholesterol, triglycerides, lipoproteins, creatinine and endotoxin being normalized. As a result of long-term garlic intake the stabilization of indicators of his organism systems was found: namely, the molecular and cellular blood composition, the neck and head vessels, and a high adaptive and reproductive resource of the organism. Conclusion. After the introduction of the garlic diet in 2007, blood tests and ultrasound examinations of the body blood vessels indicate that, despite of age and refusal to take pharmaceuticals, the triglyceridemia and hypercholesterolemia diagnoses have been withdrawn; hypertension has stopped progressing, and arterial blood pressure is stabilized. It is assumed that the bioactive components of garlic exhibit bioantioxidant and geroprotective properties and enhance tissue regeneration. Thus, a garlic-based diet may be recommended to reduce the effects of environmental stressors and to slow down the aging-associated processes.

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Gut Microbiota and Aging

Cited by 2 publications

References 90 publications

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Active longevity: long-term clinical observation

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