2023
DOI: 10.1101/2023.03.21.533195
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Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study

Abstract: The relationship between the gut microbiota, short chain fatty acid (SCFA) metabolism, and obesity remains unclear due to conflicting reports from studies with limited statistical power. Additionally, this association has rarely been explored in large scale diverse populations. Here, we investigated associations between fecal microbial composition, predicted metabolic potential, SCFA concentrations, and obesity in a large (N = 1,934) adult cohort of African-origin spanning the epidemiologic transition, from Gh… Show more

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Cited by 1 publication
(2 citation statements)
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“…G protein-coupled receptors are also expressed on pancreatic β cells, which can be mediated by SCFAs to modulate insulin secretion. The abundance of SCFA-producing bacteria, such as Faecalibacterium prausnitzii, is reduced in obese and aged gut microbiota [82,89,90] . Research shows a relationship between higher fecal SCFA concentrations and measures of obesity, gut permeability, metabolic dysregulation, and hypertension [91] , indicating a lack of absorption of SCFAs.…”
Section: Alterations To Gut Function In Obesity and Agingmentioning
confidence: 99%
See 1 more Smart Citation
“…G protein-coupled receptors are also expressed on pancreatic β cells, which can be mediated by SCFAs to modulate insulin secretion. The abundance of SCFA-producing bacteria, such as Faecalibacterium prausnitzii, is reduced in obese and aged gut microbiota [82,89,90] . Research shows a relationship between higher fecal SCFA concentrations and measures of obesity, gut permeability, metabolic dysregulation, and hypertension [91] , indicating a lack of absorption of SCFAs.…”
Section: Alterations To Gut Function In Obesity and Agingmentioning
confidence: 99%
“…• Akkermansia muciniphila [52,54] • Faecalibacterium prausnitzii [82,89] • Bifidobacterium [56,82] • α-diversity [52,54] • Decreased TJs and barrier integrity [78,85] • Decreased SCFAs [82,90] • Inflamed colon [79,85] • Mucus degradation [52,76,82] • Increased permeability [76,82] • Bacterial translocation [79,82] TJs: Tight junctions; SCFAs: short-chain fatty acids.…”
Section: Gut Dysbiosis Leads To Adipocyte Dysfunctionmentioning
confidence: 99%