2024
DOI: 10.3389/fmicb.2024.1377392
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Gut microbiota and functional dyspepsia: a two-sample Mendelian randomization study

Yichuan Xv,
Jiaxu Chen,
Jiang Lin

Abstract: BackgroundNumerous studies have established that alterations in the gut microbiota (GM) constitute an embedded mechanism in functional dyspepsia (FD). However, the specific GM taxa implicated in the pathological process of FD have remained unclear.MethodsA two-sample Mendelian randomization analysis was initially conducted to examine the causal relationships between GM and FD, utilizing GWAS data from the MiBioGen Consortium (18,340 cases) and FinnGenn (8,875 cases vs. 320,387 controls). The MR study primarily… Show more

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