Gut microbiota and ionizing radiation-induced damage: Is there a link?

Yu, Yueqiu; Lin, Xin; Feng, Feiyang; Wei, Yuanyun; Wei, Shuang; Gong, Yaqi; Guo, Caimao; Wang, Qingyu; Shuai, Peimeng; Wang, Tiantian; Hui, Qing; Li, Guoqing; Liang, Yi

doi:10.1016/j.envres.2023.115947

Cited by 13 publications

(4 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its major advantages are as follows: (1) capable of dynamically analyzing the overall composition of metabolites, including feces, urine, blood, and secretions and cells of the body; (2) high accuracy, high sensitivity, and high throughput; and (3) based on multivariate statistical analysis methods, it can intuitively illustrate the pathological and physiological status of the research object, environmental factors, and the relationships between various groups of information, and obtain biomarkers [ 13 , 14 ]. This approach can explain the basic form of gut microbial metabolism and more accurately analyze the metabolic system, and consequently, the results obtained with this approach can help study the relationship between gut microbiota and the host [ [15] , [16] , [17] ].…”

Section: Discussionmentioning

confidence: 99%

Microbiome profiling and Co-metabolism pathway analysis in cervical cancer patients with acute radiation enteritis

Ma,

Zhao,

Zhou

2024

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Microbiome profiling and Co-metabolism pathway analysis in cervical cancer patients with acute radiation enteritis

Ma,

Zhao,

Zhou

2024

Heliyon

View full text Add to dashboard Cite

“…Recent research has revealed that gut microbiomes and metabolism are significantly altered by IR [ 5 – 10 , 24 – 26 ]. However, few studies have focused on the effects of IR from radionuclides [ 4 , 21 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since 131 I is administered orally, it accumulates in the gastrointestinal tract and may affect gut microbes [ 4 ]. Until now, many studies have reported that ionizing radiation (IR) affects the structure, function, and species of the gut microbiota and its metabolites by triggering dysbiosis, further exacerbating damage induced by IR [ 5 – 8 ]. On the contrary, beneficial bacteria and favorable metabolites could rebuild the IR-injured gut microbial structure via anti-inflammatory and anti-oxidant mechanisms [ 6 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Early and long-term responses of intestinal microbiota and metabolites to 131I treatment in differentiated thyroid cancer patients

Lu,

Gao,

Liu

et al. 2024

BMC Med

View full text Add to dashboard Cite

Background Multiple high doses of 131I therapy in patients with differentiated thyroid cancer (DTC) might disrupt the balance of gut microbiota and metabolites. This study aimed to investigate the alterations of intestinal bacteria and metabolism over two courses of 131I therapy, explore the interactions, and construct diagnostic models reflecting enteric microecology based on 131I therapy. Methods A total of 81 patients were recruited for the first 131I therapy (131I-1st), among whom 16 received a second course (131I-2nd) after half a year. Fecal samples were collected 1 day before (Pre-131I-1st/2nd) and 3 days after (Post-131I-1st/2nd) 131I therapy for microbiome (16S rRNA gene sequencing) and metabolomic (LC–MS/MS) analyses. Results A total of six microbial genera and 11 fecal metabolites enriched in three pathways were identified to show significant differences between Pre-131I-1st and other groups throughout the two courses of 131I treatment. In the Post-131I-1st group, the beneficial bacteria Bifidobacterium, Lachnoclostridium, uncultured_bacterium_f_Lachnospiraceae, and Lachnospiraceae_UCG004 were abundant and the radiation-sensitive pathways of linoleic acid (LA), arachidonic acid, and tryptophan metabolism were inhibited compared with the Pre-131I-1st group. Compared with the Pre-131I-1st group, the Pre-131I-2nd group exhibited a reduced diversity of flora and differentially expressed metabolites, with a low abundance of beneficial bacteria and dysregulated radiation-sensitive pathways. However, less significant differences in microbiota and metabolites were found between the Pre/Post-131I-2nd groups compared with those between the Pre/Post-131I-1st groups. A complex co-occurrence was observed between 6 genera and 11 metabolites, with Lachnoclostridium, Lachnospiraceae_UCG004, Escherichia-Shigella, and LA-related metabolites contributing the most. Furthermore, combined diagnostic models of charactered bacteria and metabolites answered well in the early, long-term, and dose-dependent responses for 131I therapy. Conclusions Different stages of 131I therapy exert various effects on gut microecology, which play an essential role in regulating radiotoxicity and predicting the therapeutic response.

show abstract

“…Considerable gut microbiome variations must therefore be assumed between the animals in the two experiments. It has been well documented that a complete and functional gut microbiome may lower gastrointestinal radiosensitivity, and conversely that ionizing radiation adversely affects the gut microbiome [42][43][44].…”

Section: Acute Effects Of Total Body and Bone Marrow-spared Irradiationmentioning

confidence: 99%

Effects of Bone Marrow Sparing and TGF-β3 Treatment in Total Body Irradiation of C57BL/6J Mice

Hanson,

Vatne,

Edin

2024

Applied Biosciences

View full text Add to dashboard Cite

Introduction: Mortality from acute radiation syndrome is frequently caused by hematopoietic or gastrointestinal radiotoxicity, the latter of which currently has no effective treatment. Transforming growth factor-beta 3 (TGF-β3) may decrease the severity of radiation-induced gastrointestinal damage in mice. In addition, treatment with TGF-β3 may alleviate radiation-induced fibrosis. Objectives: The current study aimed to investigate the effect of TGF-β3 treatment on acute and late radiotoxicity in whole body irradiated mice. Methods: C57BL/6J mice were total body irradiated with 8.5 Gy X-rays with or without shielding of one hind leg to alleviate hematopoietic radiotoxicity. The effects of intravenous TGF-β3 treatment were investigated. Body weight and pain expression were monitored. Intestine, lung, and liver tissues were preserved and analyzed. Alpha smooth muscle actin (α-SMA) expression in MRC-5 cells after 3.5 Gy X-irradiation combined with TGF-β3 treatment was analyzed using flow cytometry. Results: All total body irradiated animals died within ten days after irradiation. Ninety-three percent of femur-shielded mice survived until sampling or termination. No effect of TGF-β3 treatment was observed in either group. No increase in collagen content was detected in the lungs or liver from irradiated mice regardless of TGF-β3 treatment. In vitro, α-SMA expression increased synergistically after irradiation and TGF-β3 treatment. Conclusions: Shielding of the femur during total body irradiation decreased acute gastrointestinal radiation toxicity and increased survival. TGF-β3 treatment did not impact symptoms or survival. TGF-β3 treatment and irradiation increased α-SMA expression in MRC-5 cells synergistically.

show abstract

Gut microbiota and ionizing radiation-induced damage: Is there a link?

Cited by 13 publications

References 123 publications

Microbiome profiling and Co-metabolism pathway analysis in cervical cancer patients with acute radiation enteritis

Microbiome profiling and Co-metabolism pathway analysis in cervical cancer patients with acute radiation enteritis

Early and long-term responses of intestinal microbiota and metabolites to 131I treatment in differentiated thyroid cancer patients

Effects of Bone Marrow Sparing and TGF-β3 Treatment in Total Body Irradiation of C57BL/6J Mice

Contact Info

Product

Resources

About