Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Liu, Lanxiang; Wang, Haiyang; Chen, Xueyi; Zhang, Yangdong; Zhang, Hanping; Xie, Peng

doi:10.1016/j.ebiom.2023.104527

Cited by 188 publications

(57 citation statements)

References 115 publications

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“…These microbiota were also short-chain, fatty acidproducing bacteria, which previous studies have associated with depression and anxiety disorders. 36,37,38 In particular, previous studies have shown that Subdoliglunulm is associated with diet quality. For example, those on a Western-style, low-fiber diet rich in processed meats, fat, sugar, and sodium had reduced Subdoliglunulum compared to those on a plant-based, high-fiber diet rich in fruits, vegetables, and whole grains.…”

Section: Discussionmentioning

confidence: 99%

The Association of Maternal Depression with Short-Chain Fatty Acid-Producing Gut Microbiota and the Japanese Diet’s Influence

Matsunaga,

Takeuchi,

Watanabe

et al. 2023

Preprint

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The prevalence of postpartum mental illness is steadily increasing, exacerbated particularly by the COVID-19 pandemic. Recent studies indicate that maternal depression is no longer confined to the perinatal period, necessitating long-term assessment, and support for maternal mental health. Identifying risk factors for mothers’ depression is thus critical and requires development of integrated mental and physical health care that encompasses not only psychological aspects but also gut microbiota, physical condition, and eating habits. Western countries have examined the association between gut microbiota and depression in clinical samples. However, studies focusing on postpartum mothers are still limited, and moreover, no large-scale studies have yet been conducted with nonclinical participants. To address this gap, we investigated gut microbiota, physical condition, and dietary habits associated with risk of depression in nonclinical Japanese mothers. We found that microbiota diversity (Shannon α) and relative abundance of butyrate-producing bacteria (e.g., Lachnospira, Faecalibacterium, Lachnoclostridium) with 16S rRNA gene-sequencing analysis were associated with high risk of depression. Furthermore, even among nonclinical mothers, high-risk mothers showed poorer sleep quality, worse physical condition, and lower consumption of staple foods, milk, cheese, yogurt, and lactobacillus beverages compared to low-risk (healthy) mothers. Evaluation of dietary habits using the Japanese Dietary Index (JDI) suggested that consumption of a Japanese-style diet is beneficial to physical and mental health, including intestinal microbiota (e.g., Agathobacter, Subdoligranulum).

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Section: Discussionmentioning

confidence: 99%

The Association of Maternal Depression with Short-Chain Fatty Acid-Producing Gut Microbiota and the Japanese Diet’s Influence

Matsunaga,

Takeuchi,

Watanabe

et al. 2023

Preprint

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“…The use of microbiota manipulation as an antidepressant is an intriguing prospect. Indeed there is increasing evidence of a bidirectional influence between microbiota composition and depression [ 87 ]. Abnormalities in the microbiota affect gut permeability, inflammatory status and, indirectly, brain neurotransmitters.…”

Section: Microbiotamentioning

confidence: 99%

A Critical View on New and Future Antidepressants

Serretti

2024

Clin Psychopharmacol Neurosci

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For the first time after many decades, many new antidepressants have been approved and many more are under various stages of development and will soon be available in the market. The new drugs present a range of new mechanisms of action with benefits in terms of speed of action, tolerability and range of treatable disorders. Neurosteroids have been recently approved and their rapid benefit may extend from postpartum depression to anxious depression and bipolar depression, dextromethorphan and bupropion combination may prove useful in major depression but also in treatment resistant depression, dextromethadone is a possible augmentation in partial antidepressant response, psychedelic drugs have the potential of long lasting benefits after a single administration, though are still experimental treatments. Botulinum has the same advantage of psychedelics of a single administration and its antidepressant effects may last for weeks or more. Further potentially interesting new antidepressant mechanisms include new drug targets, drug repurposing and genetic or epigenetic manipulations. It is therefore important that clinicians are kept up to date with new evidence so that new evidence can be rapidly translated into clinical practice.

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“…Stress-induced effects on the gastrointestinal tract via the intestinal−brain axis notably include alterations in intestinal motility, visceral discomfort, changes in secretory capacity, and intestinal mucosal permeability [ 73 ]. These alterations significantly influence the composition and functionality of the gut microbiota, potentially leading to dysbiosis, which in turn may exacerbate anxiety symptoms within the gut/brain axis framework [ 74 ].…”

Section: Brain and Intestinal Microbiotic Interaction: A Molecular Pe...mentioning

confidence: 99%

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

Toader,

Dobrin,

Costea

et al. 2024

IJMS

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Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies and expand the boundaries of neuropharmacology, studies from the field have highlighted the gut microbiota’s role in modulating these disorders. These alterations may influence the brain’s processes through the brain–gut axis, a multifaceted bidirectional system that establishes a connection between the enteric and central nervous systems. Thus, probiotic and prebiotic supplements that are meant to influence overall gut health may play an insightful role in alleviating psychiatric symptoms, such as the cognitive templates of major depressive disorder, anxiety, or schizophrenia. Moreover, the administration of psychotropic drugs has been revealed to induce specific changes in a microbiome’s diversity, suggesting their potential utility in combating bacterial infections. This review emphasizes the intricate correlations between psychiatric disorders and the gut microbiota, mentioning the promising approaches in regard to the modulation of probiotic and prebiotic treatments, as well as the antimicrobial effects of psychotropic medication.

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Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Cited by 188 publications

References 115 publications

The Association of Maternal Depression with Short-Chain Fatty Acid-Producing Gut Microbiota and the Japanese Diet’s Influence

The Association of Maternal Depression with Short-Chain Fatty Acid-Producing Gut Microbiota and the Japanese Diet’s Influence

A Critical View on New and Future Antidepressants

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

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