Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s Disease

Zhu, Guangsu; Zhao, Jianxin; Zhang, Hao; Wang, Gang; Chen, Wei

doi:10.1016/j.advnut.2023.04.005

Cited by 23 publications

(7 citation statements)

References 218 publications

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“…Bacteria that the Mediterranean diet promotes growth of include Prevotella , Bifidobacteria , Eubacterium eligens, and Bacteroides . The result is an increase in SCFA and bioactive compounds that can cross the BBB bacteria [ 94 ]. It is postulated that thanks to unsaturated fats and fiber, it reduces the risk of metabolic endotoxemia, i.e., a two-to-three-fold increase in LPS [ 95 ].…”

Section: Diet In Neurodegenerative Diseasesmentioning

confidence: 99%

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Czarnik,

Fularski,

Gajewska

et al. 2024

Nutrients

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Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain–gut axis is an object that remains the target of modern research, and it is not without reason that many researchers enrich it with microbiota and diet in its name. Numerous connections and mutual correlations have become the basis for seeking answers to many questions related to pathology as well as human physiology. Disorders of this homeostasis as well as dysbiosis itself accompany neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Heavily dependent on external factors, modulation of the gut microbiome represents an opportunity to advance the treatment of neurodegenerative diseases. Probiotic interventions, synbiotic interventions, or fecal transplantation can undoubtedly support the biotherapeutic process. A special role is played by diet, which provides metabolites that directly affect the body and the microbiota. A holistic view of the human organism is therefore essential.

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Section: Diet In Neurodegenerative Diseasesmentioning

confidence: 99%

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Czarnik,

Fularski,

Gajewska

et al. 2024

Nutrients

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“…32 Moreover, Arg was another important amino acid that potentially affects brain function, and combined supplementation with Arg and probiotic LKM512 had possible neuroprotective effects on the brain. 8 Arg-Gly dipeptide has been found to promote BDNF expression and increase the number of neurons in the hippocampus and cortex of the brain. 33 Consequently, THPH and WPH, which were enriched in low-MW peptides, Glu and other amino acids, may have potential brainnourishing activity.…”

Section: Amino Acid Composition and Mw Distribution Of Thph And Wphmentioning

confidence: 99%

“…Some evidence from studies from animal models and humans have shown multiple relationships between cognitive dysfunction and gut microbiota, particularly the phylum Bacteroidota and Firmicutes. 8 These microbial metabolites, including transformation of dietary components, microbe-host co-metabolites, and metabolites shared by the host and bacterial metabolic pathways, modulated cognitive and memory functions through affecting short-chain fatty acid metabolism, amino acid metabolism, bile acid metabolism, and metabolic pathways associated with neurotransmitters and polyamines, which were highly complex. Further studies have shown that multiple metabolic pathways, mainly including amino acid and lipid metabolism, are disrupted in CI mice or patients, 9,10 which were related to the host gut microecological imbalances.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of tilapia head protein hydrolysate and walnut protein hydrolysate on the amelioration of cognitive impairment in mice

Ji,

Yi,

Gao

et al. 2024

J Sci Food Agric

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BackgroundCognitive impairment (CI) is a significant public health concern, and bioactive peptides have shown potential as therapeutic agents. However, information about their synergistic effects on cognitive function is still limited. Here, we investigated the synergistic effects of Tilapia Head Protein Hydrolysate (THPH) and Walnut Protein Hydrolysate (WPH) in mitigating CI induced by scopolamine in mice.ResultsThe results showed that the combined supplementation of THPH and WPH (mass ratio, 1:1) was superior to either individual supplement in enhancing spatial memory and object recognition abilities in CI mice, and significantly lessened brain injury in CI mice by alleviating neuronal damage, reducing oxidative stress, and stabilizing the cholinergic system. In addition, the combined supplementation was found to be more conducive to remodeling the gut microbiota structure in CI mice, not only remarkably reducing the ratio of Firmicutes to Bacteroidota, but specifically enriching the genus Roseburia. On the other hand, the combined supplementation regulated the disorders of sphingolipid and amino acid metabolism in CI mice, particularly upregulating glutathione and histidine metabolism, and displayed a stronger ability to increase the expression of genes and proteins related to the BDNF/TrkB/CrEB signaling pathway in the brain.ConclusionThese findings demonstrated that tilapia head and walnut‐derived protein hydrolysates exerted synergistic effects in ameliorating CI, which was achieved through modulation of gut microbiota, serum metabolic pathways, and BDNF signaling pathways.This article is protected by copyright. All rights reserved.

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“…The human gut microbiome profoundly influences our health and well-being, not only in terms of physical health but also as a modulator of brain function and behavior, including mood, cognition, and stress responses [ 23 , 47 ]. With the ongoing psychedelic renaissance exploring the therapeutic potentials of psychedelic substances like psilocybin, lysergic acid diethylamide (LSD), and ayahuasca, it is essential to consider the role of the gut microbiome in this narrative.…”

Section: Microbiome and Psychedelic Interactionmentioning

confidence: 99%

Microbiome: The Next Frontier in Psychedelic Renaissance

Kargbo

2023

JoX

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The psychedelic renaissance has reignited interest in the therapeutic potential of psychedelics for mental health and well-being. An emerging area of interest is the potential modulation of psychedelic effects by the gut microbiome—the ecosystem of microorganisms in our digestive tract. This review explores the intersection of the gut microbiome and psychedelic therapy, underlining potential implications for personalized medicine and mental health. We delve into the current understanding of the gut–brain axis, its influence on mood, cognition, and behavior, and how the microbiome may affect the metabolism and bioavailability of psychedelic substances. We also discuss the role of microbiome variations in shaping individual responses to psychedelics, along with potential risks and benefits. Moreover, we consider the prospect of microbiome-targeted interventions as a fresh approach to boost or modulate psychedelic therapy’s effectiveness. By integrating insights from the fields of psychopharmacology, microbiology, and neuroscience, our objective is to advance knowledge about the intricate relationship between the microbiome and psychedelic substances, thereby paving the way for novel strategies to optimize mental health outcomes amid the ongoing psychedelic renaissance.

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Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s Disease

Cited by 23 publications

References 218 publications

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Synergistic effects of tilapia head protein hydrolysate and walnut protein hydrolysate on the amelioration of cognitive impairment in mice

Microbiome: The Next Frontier in Psychedelic Renaissance

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