Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review

Wang, Chen; Gu, Yu; Chu, Qiao; Wang, Xin; Ding, Yiyun; Qin, Xiali; Liu, Tianyu; Wang, Sinan; Liu, Xiang; Wang, Bangmao; Cao, Hailong

doi:10.1016/j.micres.2024.127660

Cited by 6 publications

(3 citation statements)

References 147 publications

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“…Further investigations on a larger population including patients with active disease are needed, also considering the wide range of available therapies and the pathogenetic implications of some new biomarkers, such as miRNAs [31]. Although our results do not show significant differences related to the various treatments, future well-designed longitudinal omics studies could assess the role of dysbiosis in therapeutic management and in the development of innovative tailored approaches [32].…”

Section: Discussionmentioning

confidence: 69%

Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study

De Caro,

Spagnuolo,

Quirino

et al. 2024

IJMS

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Gut microbiota imbalances have a significant role in the pathogenesis of Inflammatory Bowel Disease (IBD) and Non-Alcoholic Fatty Liver Disease (NAFLD). Herein, we compared gut microbial composition in patients diagnosed with either IBD or NAFLD or a combination of both. Seventy-four participants were stratified into four groups: IBD-NAFLD, IBD-only, NAFLD-only patients, and healthy controls (CTRLs). The 16S rRNA was sequenced by Next-Generation Sequencing. Bioinformatics and statistical analysis were performed. Bacterial α-diversity showed a significant lower value when the IBD-only group was compared to the other groups and particularly against the IBD-NAFLD group. β-diversity also showed a significant difference among groups. The higher Bacteroidetes/Firmicutes ratio was found only when comparing IBD groups and CTRLs. Comparing the IBD-only group with the IBD-NAFLD group, a decrease in differential abundance of Subdoligranulum, Parabacteroides, and Fusicatenibacter was found. Comparing the NAFLD-only with the IBD-NAFLD groups, there was a higher abundance of Alistipes, Odoribacter, Sutterella, and Lachnospira. An inverse relationship in the comparison between the IBD-only group and the other groups was shown. For the first time, the singularity of the gut microbial composition in IBD and NAFLD patients has been shown, implying a potential microbial signature mainly influenced by gut inflammation.

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Section: Discussionmentioning

confidence: 69%

Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study

De Caro,

Spagnuolo,

Quirino

et al. 2024

IJMS

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“…N time period was specified, and duplicate articles were removed. The investigation about possible markers that can be used for diagnostic and therapeutic purposes is very active in human medicine, and this is demonstrated by the publication of several recent papers concerning this topic [14][15][16]. Metabolomics can be used to clarify the pathogenetic mechanisms underlying certain diseases or even for research concerning mechanisms underlying the interaction between pathogens and the host.…”

Section: Methodsmentioning

confidence: 99%

“…Even if the only post-processing steps of the spec tra were referencing alanine's signals at 1.46 ppm and normalization, the horizontal pos tion of the signals (chemical-shift) from branched amino acids appears as perfectly con sistent across the entire samples' set. The investigation about possible markers that can be used for diagnostic and thera peutic purposes is very active in human medicine, and this is demonstrated by the publ cation of several recent papers concerning this topic [14][15][16]. Metabolomics can be used t clarify the pathogenetic mechanisms underlying certain diseases or even for research con cerning mechanisms underlying the interaction between pathogens and the host.…”

Section: Introductionmentioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Laus,

Bazzano,

Spaterna

et al. 2024

Metabolites

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Metabolomics can allow for the comprehensive identification of metabolites within biological systems, at given time points, in physiological and pathological conditions. In the last few years, metabolomic analysis has gained popularity both in human and in veterinary medicine, showing great potential for novel applications in clinical activity. The aim of applying metabolomics in clinical practice is understanding the mechanisms underlying pathological conditions and the influence of certain stimuli (i.e., drugs, nutrition, exercise) on body systems, in the attempt of identifying biomarkers that can help in the diagnosis of diseases. Proton Nuclear Magnetic Resonance spectroscopy (1H-NMR) is well tailored to be used as an analytical platform for metabolites’ detection at the base of metabolomics studies, due to minimal sample preparation and high reproducibility. In this mini-review article, the scientific production of NMR metabolomic applications to equine medicine is examined. The research works are very different in methodology and difficult to compare. Studies are mainly focused on exercise, reproduction, and nutrition, other than respiratory and musculoskeletal diseases. The available information on this topic is still scant, but a greater collection of data could allow researchers to define new reliable markers to be used in clinical practice for diagnostic and therapeutical purposes.

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Abdominal Pain in Inflammatory Bowel Disease-Epidemiology, Pathophysiology, and Management: A Narrative Review

Tan,

Liu,

Liu

et al. 2024

Pain Ther

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Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review

Cited by 6 publications

References 147 publications

Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study

Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Abdominal Pain in Inflammatory Bowel Disease-Epidemiology, Pathophysiology, and Management: A Narrative Review

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