Gut Microbiota and Metabolites in Atrial Fibrillation Patients and Their Changes after Catheter Ablation

Kang, Hyun–Sook; Wang, Yuegang; Bai, Yang; Luo, Qian; Lin, Xuancai; Yang, Qiuyu; Wang, Shihao; Xin, Hongjie

doi:10.1128/spectrum.01077-21

Cited by 24 publications

(22 citation statements)

References 47 publications

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“…It seemed that CA enriches intestinal symbiotic bacteria and reduces pathogenic bacteria. Correspondingly, metabolites, such as oleanolic acid are downregulated after ablation, while citrulline is increased (24). This also emphasizes the crucial role of gut microbiota in AF pathogenesis.…”

Section: The Relationship Between Intestinal Flora With the Incidence...mentioning

confidence: 83%

“…Beside AF, treatment of AF is also associated with altered gut microbiome. A recent study compared gut microbiota composition in AF patients prior to catheter ablation (CA), 2 days post CA and 1 month post CA (24). Compared with preoperative condition, 6 bacterial genera (Prevotella, Lactobacillus, Sutterella, Alistipes, Parabacteroides, and Streptococcus) enriched and 3 genera (Blautia, Ruminococcus_gnavus_group, and Anaerostipes) remarkably decreased 2 days after CA.…”

Section: The Relationship Between Intestinal Flora With the Incidence...mentioning

confidence: 99%

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The Relationship Between Atrial Fibrillation and Intestinal Flora With Its Metabolites

Zou²,

Zhang³

2022

Front. Cardiovasc. Med.

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Atrial fibrillation (AF) is characterized by high morbidity and disability rate. The incidence of AF has rapidly increased due to increased aging population, causing a serious burden on society and patients. Therefore, it is necessary to determine the prevention and treatment of AF. Several studies have assessed the occurrence, development mechanism, and intervention measures of AF. The human gut has several non-pathogenic microorganisms forming the gut flora. The human gut microbiota plays a crucial role in the construction and operation of the metabolic system and immune system. Emerging clinical studies and basic experiments have confirmed that intestinal flora and its metabolites have a role in some metabolic disorders and chronic inflammatory diseases. Moreover, the gut microbiota has a role in cardiovascular diseases, such as hypertension and heart failure. However, the relationship between AF and gut microbiota is unclear. This review summarizes the relevant literature on the relationship between AF and intestinal flora with its metabolites, including Trimethylamine N-Oxide, short-chain fatty acids, lipopolysaccharide and bile acids. Therefore, this review may enhance further development of related research.

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Section: The Relationship Between Intestinal Flora With the Incidence...mentioning

confidence: 83%

Section: The Relationship Between Intestinal Flora With the Incidence...mentioning

confidence: 99%

The Relationship Between Atrial Fibrillation and Intestinal Flora With Its Metabolites

Zou²,

Zhang³

2022

Front. Cardiovasc. Med.

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“…A cohort study observed that patients with atrial fibrillation and control groups shared 1,189 operational taxonomic units (OTUs). Within them, 897 specific OTUs were observed exclusively in patients having atrial fibrillation, whereas only 477 were observed only in controls [ 58 ].…”

Section: Reviewmentioning

confidence: 99%

“…Haemophilus , Alistipes , Enterococcus , Weissella , Parabacteroides , Megamonas , Streptococcus , and Klebsiella were in high concentration in patients with atrial fibrillation. Agathobacter concentrations were observed to be higher in the control group [ 58 ].…”

Section: Reviewmentioning

confidence: 99%

Analyzing the Complicated Connection Between Intestinal Microbiota and Cardiovascular Diseases

Kumar¹,

Dutta²,

Velagala³

et al. 2022

Cureus

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Relentless human curiosity to understand the basis of every aspect of medical science has led humanity to unlock the deepest secrets about the physiology of human existence and, in the process, has reached milestones that a century ago could only be imagined. Recent ground-breaking breakthroughs have helped scientists and physicians all over the world to update the scientific basis of diseases and hence further improve treatment outcomes. According to recent studies, scientists have found a link between intestinal flora and the pathogenesis of diseases, including cardiovascular diseases. Any change in the typical habitat of gut microbiota has been shown to result in the culmination of various metabolic and cardiac diseases. Therefore, gut microbiota can be credited for influencing the course of the development of a disease. Any change in the composition and function of bacterial species living in the gut can result in both beneficial and harmful effects on the body. Gut microbiota achieves this role by numerous mechanisms. Generations of various metabolites like TMAO (trimethylamine N-oxide), increased receptibility of various bacterial antigens, and disruption of the enzyme action in various metabolic pathways like the bile acids pathway may result in the development of metabolic as well as cardiovascular diseases. Even if they may not be the only etiological factor in the pathogenesis of a disease, they may very well serve as a contributing factor in worsening the outcome of the condition. Studies have shown that they actively play a role in the progression of cardiovascular diseases like atherosclerotic plaque formation and rising blood pressure. The focus of this review article is to establish a relation between various cardiovascular diseases and gut microbiota. This could prove beneficial for clinicians, health care providers, and scientists to develop novel therapeutic algorithms while treating cardiac patients.

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“…Another mechanism through which microbiota can promote the development of HF is atrial fibrillation [ 87 ], which is associated with a high concentration of Proteobacteria , Actinobacteria and Firmicutes , Streptococcus , Haemophilus , Alistipes , Enterococcus , and Klebsiella [ 88 ]. Gram-negative lipopolysaccharides (LPS) are endotoxins able to trigger NLRP3 inflammasomes with consequent caspase-1 activation and the production of IL-1β and IL-18.…”

Section: Gut Microbiota Composition and Hfmentioning

confidence: 99%

The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies

et al. 2022

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Heart failure is a complex health issue, with important consequences on the overall wellbeing of patients. It can occur both in acute and chronic forms and, in the latter, the immune system appears to play an important role in the pathogenesis of the disease. In particular, in the forms with preserved ejection fraction or with only mildly reduced ejection fraction, some specific associations with chronic inflammatory diseases have been observed. Another interesting aspect that is worth considering is the role of microbiota modulation, in this context: given the importance of microbiota in the modulation of immune responses, it is possible that changes in its composition may somewhat influence the progression and even the pathogenesis of heart failure. In this narrative review, we aim to examine the relationship between immunity and heart failure, with a special focus on the role of microbiota in this pathological condition.

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Gut Microbiota and Metabolites in Atrial Fibrillation Patients and Their Changes after Catheter Ablation

Cited by 24 publications

References 47 publications

The Relationship Between Atrial Fibrillation and Intestinal Flora With Its Metabolites

The Relationship Between Atrial Fibrillation and Intestinal Flora With Its Metabolites

Analyzing the Complicated Connection Between Intestinal Microbiota and Cardiovascular Diseases

The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies

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