Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System

Bruning, Jessica; Chapp, Andrew D.; Kaurala, Gregory A; Wang, Renjun; Techtmann, Stephen M.; Chen, Qing‐Hui

doi:10.1007/s12264-019-00410-8

Cited by 34 publications

(19 citation statements)

References 12 publications

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“…Although COVID-19 is primarily a respiratory infection, it also affects the gastrointestinal tract [9,11]. It has been well documented that most chronic diseases such as obesity, diabetes, hypertension, and heart disease are linked to gut dysbiosis [40,49,75] and also to COVID-19 complications [10,14], making the gut microbiome an essential part to consider in understanding COVID-19. Over the past few years, microbiome research, thanks to NGS technologies, allowed us to better understand the role of gut, mouth, urogenital, and lung microbiomes in health and disease [17,37,48].…”

Section: Discussionmentioning

confidence: 99%

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Gut-Lung Axis in COVID-19

Allali

Bakri

Amzazi

et al. 2021

Interdisciplinary Perspectives on Infectious Diseases

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COVID-19 is a pandemic infection of the respiratory system caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral ribonucleic acid (RNA) was found in many parts of the COVID-19 patients including the stool, suggesting a potential interaction with the host’s gut microbiome. The gut microbiome also plays major roles in immunity and inflammation. It also impacts pulmonary functions through the gut-lung axis. There have been recent reports of the importance of the host microbiome in infection and pathogenicity. The understanding of the gut and lung microbiomes would open the gate to new therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

“…It is well known that the gut microbiome plays a major role in initiating, adapting, and regulating the immune response [47,48]. e gut microbiome produces a certain number of metabolites, such as short-chain fatty acids (SCFAs) [49]. SCFAs are products of the fermentation of carbohydrates by anaerobic bacteria present in the colon.…”

Section: Gut-lung Axismentioning

confidence: 99%

Gut-Lung Axis in COVID-19

Allali

Bakri

Amzazi

et al. 2021

Interdisciplinary Perspectives on Infectious Diseases

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“…2) [90]. Evidence shows that SCFAs are associated with neurodegeneration [91]. Ho et al found by in vitro experiments that selected SCFAs, especially butyric acid, valeric acid, and propionic acid, inhibit Ab aggregation, which suggests the potential of SCFAs for treating AD.…”

Section: Short-chain Fatty-acids and Neurodegenerative Diseasesmentioning

confidence: 99%

The Relationship Between the Gut Microbiome and Neurodegenerative Diseases

Xiao-hong

Lou

et al. 2021

Neurosci. Bull.

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Many recent studies have shown that the gut microbiome plays important roles in human physiology and pathology. Also, microbiome-based therapies have been used to improve health status and treat diseases. In addition, aging and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, have become topics of intense interest in biomedical research. Several researchers have explored the links between these topics to study the potential pathogenic or therapeutic effects of intestinal microbiota in disease. But the exact relationship between neurodegenerative diseases and gut microbiota remains unclear. As technology advances, new techniques for studying the microbiome will be developed and refined, and the relationship between diseases and gut microbiota will be revealed. This article summarizes the known interactions between the gut microbiome and neurodegenerative diseases, highlighting assay techniques for the gut microbiome, and we also discuss the potential therapeutic role of microbiome-based therapies in diseases.

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“…The mammalian gut microbiota not only affects the host's immune system but also its autonomous [156,157] and central [158,159] Plants are also able to cope with their microbiota through the emission of extracellular vesicles [79] and complex cross-talks through their respective secretomes to constitute functional holobionts [166]. The arbuscular mycorrhizal (AM) fungi have developed a symbiotic relationship with most (>80%) land plants; this is highly beneficial for the uptake of minerals and water from the soil by plants [167,168] and for providing carbon sources to fungi.…”

Section: Bacteria In Animalsmentioning

confidence: 99%

Cell Communications among Microorganisms, Plants, and Animals: Origin, Evolution and Interplays

Combarnous

Nguyen

2020

Preprint

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Cellular communications play pivotal roles in multi-cellular species, but they do so also in uni-cellular species. Moreover, cells communicate with each other not only within the same individual but also with cells in other individuals belonging to the same or other species. These communications occur between two unicellular species, two multicellular species, or between unicellular and multicellular species. The molecular mechanisms involved exhibit diversity and specificity, but they share common basic features which allow common pathways of communication between different, and sometimes very different species. These interactions have been made possible by the high degree of conservation of the basic molecular mechanisms of interaction of many ligand-receptor pairs in evolutionary remote species. These inter-species cellular communications played crucial roles during Evolution and must have been positively selected, particularly when collectively beneficial in hostile environments. We think that communications between cells did not arise after their emergence but was part of the very nature of first cells. Synchronization of populations of non-living protocells through chemical communications may have been a mandatory step towards their emergence as populations of living cells and explain the large commonality of cell communication mechanisms among microorganisms, plants, and animals.

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Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System

Cited by 34 publications

References 12 publications

Gut-Lung Axis in COVID-19

Gut-Lung Axis in COVID-19

The Relationship Between the Gut Microbiome and Neurodegenerative Diseases

Cell Communications among Microorganisms, Plants, and Animals: Origin, Evolution and Interplays

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