Gut microbiota as a potential target for developing anti-fatigue foods

Li, Yinghui; Li, Junjun; Xu, Fengqin; Liu, Guanwen; Pang, Bing; Liao, Ning; Li, Huixin; Shi, Junling

doi:10.1080/10408398.2021.1983768

Cited by 17 publications

(21 citation statements)

References 122 publications

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“…Pharmacological and clinical studies have consistently shown that polysaccharides have immunoregulatory activity. The gut microbiota is good at using polysaccharides as an energy source and plays a key role in disease development [ 38 ]. Therefore, the regulation of gut microbiota has become a new target to control the progression of colorectal cancer [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice

Shen

et al. 2022

IJMS

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Chondroitin sulfate (CS) is a well-known bioactive substance with multiple biological functions, which can be extracted from animal cartilage or bone. Sturgeon, the largest soft bone animal with ~20% cartilage content, is a great candidate for CS production. Our recent study confirmed the role of sturgeon chondroitin sulfate (SCS) in reducing colorectal cancer cell proliferation and tumor formation. Here, we further studied the effect of SCS on modulating gut microbiome structure in colorectal cancer bearing mice. In this study, the transplanted tumor mice model was constructed to demonstrate that SCS can effectively halt the growth of transplanted colorectal tumor cells. Next, we showed that SCS significantly altered the gut microbiome, such as the abundance of Lactobacillales, Gastranaerophilales, Ruminiclostridiun_5 and Ruminiclostridiun_6. According to linear discriminant analysis (LDA) and abundance map analysis of the microbial metabolic pathways, the changes in microbial abundance led to an increase of certain metabolites (e.g., Phe, Tyr, and Gly). Fecal metabolome results demonstrated that SCS can significantly reduce the amount of certain amino acids such as Phe, Pro, Ala, Tyr and Leu presented in the feces, suggesting that SCS might inhibit colorectal cancer growth by modulating the gut microbiome and altering the production of certain amino acids. Our results revealed the therapeutic potential of SCS to facilitate treatment of colorectal cancer. This study provides insights into the development of novel food-derived therapies for colorectal cancer.

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Section: Resultsmentioning

confidence: 99%

Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice

Shen

et al. 2022

IJMS

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“…This contradiction might be due to the production of tryptophan by Lactobacillus and the subsequent synthesis of 5-HT in the gut. 5-HT transported to the brain affects the pituitary gland and mental mood, thereby resulting in central fatigue [ 7 ]. Butyricimonas and Anaerostipes are the main genera that produce butyrate, which regulates the neutrophil function and migration, and increases the expression of tight junction proteins in colon epithelia.…”

Section: Resultsmentioning

confidence: 99%

“…The intestinal tract is a crucial source of reactive oxygen species (ROS) and nitrogen oxide species [ 6 ]. Meanwhile, it has been declared that after the supplementation of antioxidant foods, altered intestinal bacteria promote the release of anthocyanins or polyphenols from food to increase the antifatigue capacity of the body [ 7 ]. Therefore, fatigue is greatly associated with the homeostatic control of the redox intestinal environment.…”

Section: Introductionmentioning

confidence: 99%

Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice

Zou

Yokoyama

Liu³

et al. 2023

Antioxidants

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Milk fat globule membranes (MFGMs) are complex structures that incorporate bioactive proteins and lipids to assist in infant development. However, the antifatigue and antioxidant potentials of MFGM have not been investigated. In this study, repeated force swimming measured fatigue in male BALB/c mice fed MFGM and saline for 18 weeks. The MFGM supplementation increased the time to exhaustion by 42.7% at 6 weeks and 30.6% at 14 weeks (p < 0.05). Fatigue and injury-related biomarkers, including blood glucose, lactic acid, and lactate dehydrogenase, were ameliorated after free swimming (p < 0.05). The activity of antioxidant enzymes in blood serum increased at 18 weeks, while malondialdehyde (MDA) content decreased by 45.0% after the MFGM supplementation (p < 0.05). The Pearson correlation analysis showed a high correlation between fatigue-related indices and antioxidant levels. The increased protein expression of hepatic Nrf2 reduced the protein expression of Caspase-3 in the gastrocnemius muscle (p < 0.05). Moreover, the MFGM supplementation increased the relative abundance of Bacteroides, Butyricimonas, and Anaerostipes. Our results demonstrate that MFGM may maintain redox homeostasis to relieve fatigue, suggesting the potential application of MFGM as an antifatigue and antioxidant dietary supplement.

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“…On the one hand, fatigue is associated with excessive lactate accumulation, energy deficit, and decreased central nervous system function, factors that are closely related to the metabolism of the gut microbiota. On the other hand, fatigue causes oxidative stress, inflammation, and dysfunction of the intestinal barrier, which are associated with dysregulation of the intestinal microbiota [ 41 ]. The gut microbiota associated with the occurrence of fatigue is shown in Table 1 .…”

Section: Interaction Between Gut Microbiota and Host During The Progr...mentioning

confidence: 99%

Interactions between Gut Microbiota and Polyphenols: New Insights into the Treatment of Fatigue

et al. 2022

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Fatigue seriously affects people’s work efficiency and quality of life and has become a common health problem in modern societies around the world. The pathophysiology of fatigue is complex and not fully clear. To some degree, interactions between gut microbiota and host may be the cause of fatigue progression. Polyphenols such as tannin, tea polyphenols, curcumin, and soybean isoflavones relieve fatigue significantly. Studies have shown that the gut microbiota is able to convert these active compounds into more active metabolites through intestinal fermentation. However, the mechanism of anti-fatigue polyphenols is currently mainly analyzed from the perspective of antioxidant and anti-inflammatory effects, and changes in gut microbiota are rarely considered. This review focuses on gut microecology and systematically summarizes the latest theoretical and research findings on the interaction of gut microbiota, fatigue, and polyphenols. First, we outline the relationship between gut microbiota and fatigue, including changes in the gut microbiota during fatigue and how they interact with the host. Next, we describe the interactions between the gut microbiota and polyphenols in fatigue treatment (regulation of the gut microbiota by polyphenols and metabolism of polyphenols by the gut microbiota), and how the importance of potential active metabolites (such as urolithin) produced by the decomposition of polyphenols by gut microbiota is emerging. Based on the new perspective of gut microbiota, this review provides interesting insights into the mechanism of polyphenols in fatigue treatment and clarifies the potential of polyphenols as targets for anti-fatigue product development, aiming to provide a useful basis for further research and design.

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Gut microbiota as a potential target for developing anti-fatigue foods

Cited by 17 publications

References 122 publications

Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice

Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice

Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice

Interactions between Gut Microbiota and Polyphenols: New Insights into the Treatment of Fatigue

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