Gut microbiota associated with appetite suppression in high-temperature and high-humidity environments

Wu, Yalan; Feng, Xiangrong; Li, Mengjun; Hu, Zongren; Zheng, Yuhua; Chen, Song; Luo, Huanhuan

doi:10.1016/j.ebiom.2023.104918

Cited by 6 publications

(2 citation statements)

References 73 publications

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“…Such conditions make the contamination of drinking water and food more likely, potentially leading to intestinal inflammation 12 . Furthermore, a study conducted on mice revealed a significant difference in the composition of intestinal flora, specifically the genus Thickwellia, between mice living in high-temperature environments and those in room temperature conditions 13 . Factors such as intestinal inflammation, alterations in intestinal flora, loss of appetite 14 , and the distinct dietary culture of Hainan may collectively contribute to the development of dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, types, and risk factors of functional gastrointestinal diseases in Hainan Province, China

Chen,

Zhang,

Chen

et al. 2024

Sci Rep

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To investigate the prevalence, types, and risk factors of functional gastrointestinal diseases (FGIDs) in Hainan Province, China, in order to provide insights for future prevention and treatment strategies. A questionnaire survey was conducted from July 2022 to May 2023, using stratified sampling to sample local residents in five cities (20 townships) in Hainan Province. Out of 2057 local residents surveyed, 659 individuals (32.0%) reported experiencing at least one FGID. The most prevalent FGIDs were functional dyspepsia (FD) (10.7%), functional constipation (FC) (9.3%), irritable bowel syndrome (IBS) (6.8%), functional bloating (2.2%), belching disorder (2.2%), functional diarrhea (FDr) (1.5%), functional heartburn (1.5%), and fecal incontinence (0.98%). The study revealed significant associations between FGIDs and factors such as age, sleep quality, anxiety, smoking, alcohol consumption, and the consumption of pickled food (P < 0.05). Older age, poor sleep quality, anxiety, and the consumption of pickled food were identified as independent risk factors for the prevalence of FGIDs (P < 0.05). In Hainan Province, the overall prevalence of FGIDs was found to be 32.0%, with higher prevalences of FC and FD. Older age, poor sleep quality, anxiety, and the consumption of pickled food were identified as risk factors for FGIDs.

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Section: Discussionmentioning

confidence: 99%

Prevalence, types, and risk factors of functional gastrointestinal diseases in Hainan Province, China

Chen,

Zhang,

Chen

et al. 2024

Sci Rep

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“…Mice in the NC group were maintained as described above, whereas mice in the HTH and HH groups were regularly transferred into sterilized climate chambers (model: RXZ-158A, Ningbo Jiangnan Instrument Factory, China) located in the same room. The climate chambers were set to temperatures of 32 ± 1 °C and relative humidity (RH) levels of 85–90% (HTH group) or solely 85–90% RH (HH group) over 14 consecutive days as previous described 6 , 40 . Food and drinking water were sterilized and renewed daily to avoid contamination.…”

Section: Methodsmentioning

confidence: 99%

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Chen,

Hu,

Tang

et al. 2024

Commun Biol

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High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear. We observed a decrease in plasma glucagon-like peptide-1 levels in response to high-temperature and humidity conditions. Through 16S rRNA gene sequencing, alterations in the gut microbiota composition were identified following exposure to high temperature and humidity conditions. Notably, changes in the gut microbiota have been implicated in bile acid synthesis. Further analysis revealed a decrease in lithocholic acid levels in high-temperature and humidity conditions. Subsequent in vitro experiments demonstrated that lithocholic acid increases glucagon-like peptide-1 secretion in NCI-H716 cells. Proteomic analysis indicated upregulation of farnesoid X receptor expression in the ileum. In vitro experiments revealed that the combination of lithocholic acid with farnesoid X receptor inhibitors resulted in a significant increase in GLP-1 levels compared to lithocholic acid alone. In this study, we elucidate the mechanism by which reduced lithocholic acid suppresses glucagon-like peptide 1 via farnesoid X receptor activation under high-temperature and humidity condition.

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Recent Advances in the Anti‐Obesity Benefits of Phytoconstituents: From Phytochemistry to Targeting Novel‐Systems

Xian,

Huang,

Bai

et al. 2024

Phytotherapy Research

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Obesity is a metabolic disorder that has become a global health concern. The existing pharmaceutical drugs for treating obesity have some side effects. Compounds from natural sources are prospective substitutes for treating chronic diseases such as obesity, with the added advantages of being safe and cost‐effective. However, due to factors such as poor solubility, low bioavailability, and instability in the physiological environment, the therapeutic efficacy of phytoconstituents is limited. Nowadays, developing nanoscaled systems has emerged as a vital strategy for enhancing the delivery and therapeutic effect of phytoconstituents. The present study discusses and categorizes phytoconstituents with anti‐obesity effects and concludes the main mechanisms underlying their effects. Importantly, strategies used to develop phytoconstituent‐based nano‐drug delivery systems (NDDS) for obesity treatment that show improved efficacy relative to traditional administration routes are reviewed. Finally, the progress of research on phytoconstituent‐based NDDS for obesity treatment is summarized to provide a reference for the development of safe and effective treatment strategies for obesity.

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Gut microbiota associated with appetite suppression in high-temperature and high-humidity environments

Cited by 6 publications

References 73 publications

Prevalence, types, and risk factors of functional gastrointestinal diseases in Hainan Province, China

Prevalence, types, and risk factors of functional gastrointestinal diseases in Hainan Province, China

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Recent Advances in the Anti‐Obesity Benefits of Phytoconstituents: From Phytochemistry to Targeting Novel‐Systems

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