Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity

Zou, Lin-en; Yang, Ya-nan; Zhan, Jiaguo; Cheng, Jiale; Fu, Yu; Cao, Ying; Yan, Xingxu; Wang, Yuming; Wu, Chongming

doi:10.1016/j.biopha.2024.116302

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116302

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Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity

Lin-en Zou,

Ya-nan Yang,

Jiaguo Zhan

et al.

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Cited by 3 publications

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Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data

Yang,

Cheng,

Liu

et al. 2024

eClinicalMedicine

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Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data

Yang,

Cheng,

Liu

et al. 2024

eClinicalMedicine

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From ancient wisdom to modern science: Gut microbiota sheds light on property theory of traditional Chinese medicine

Yang,

Zhan,

Cao

et al. 2024

Journal of Integrative Medicine

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Therapeutic Potential of Traditional Chinese Medicine Against Osteoarthritis: Targeting the Wnt Signaling Pathway

Zhang,

Zhan,

et al. 2024

Am. J. Chin. Med.

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Osteoarthritis (OA) is a chronic degenerative articular disease that leads to physical disability and reduced quality of life. The key pathological events in OA are cartilage degradation and synovial inflammation. Conventional therapies often lead to adverse effects that some patients are unwilling to endure. Traditional Chinese Medicines (TCMs) have long been known for their efficacy in treating OA with minimal side effects. The wingless-type (Wnt) signaling pathway is believed to play a role in OA progression, but there is still a lack of comprehensive understanding on how TCM may treat OA via the Wnt signaling pathway. This study aims to fill this gap by reviewing relevant research on the association between the Wnt signaling pathway and cartilage degradation and synovial inflammation in OA. Meanwhile, we also summarized and categorized TCMs and their active components, such as alkaloids, polysaccharides, flavonoids, sesquiterpene lactones, etc., which have shown varying efficacy in treating OA through modulation of the Wnt/[Formula: see text]-catenin signaling pathway. This work underscores the pivotal role of the Wnt signaling pathway in OA pathogenesis and progression, suggesting that targeting this pathway holds promise as a prospective therapeutic strategy for OA management in the future. TCMs and their active components have the potential to alleviate OA by modulating the Wnt signaling cascade. Harnessing TCMs and their active components to regulate the Wnt signaling pathway presents an encouraging avenue for delivering substantial therapeutic benefits to individuals with OA.

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Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity

Cited by 3 publications

References 40 publications

Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data

Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data

From ancient wisdom to modern science: Gut microbiota sheds light on property theory of traditional Chinese medicine

Therapeutic Potential of Traditional Chinese Medicine Against Osteoarthritis: Targeting the Wnt Signaling Pathway

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