Gut microbiota, bile acids, and nature compounds

Cheng, Hao; Liu, Juan; Zhang, Dandan; Tan, Yuzhu; Feng, Wuwen; Peng, Cheng

doi:10.1002/ptr.7517

Cited by 11 publications

(9 citation statements)

References 144 publications

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“…Herbal medicines such as Chai Hu ( Bupleurum chinense ) and Yu Jin ( Curcuma aromatica ) have been shown to regulate enzymes involved in bile acid synthesis, such as cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid biosynthesis from cholesterol. By modulating the activity of such enzymes, herbal medicine can alter the composition and pool size of bile acids (Li et al 2021b , 2022 ; Cheng et al 2022 ). In addition, the gut microbiota plays an essential role in converting primary bile acids into secondary bile acids.…”

Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

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The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general health as it contributes to multiple aspects of host physiology. Recent research has revealed a dynamic connection between the gut microbiota and the central nervous system, that can influence neurodegenerative diseases (NDs). Indeed, imbalances in the gut microbiota, or dysbiosis, play a vital role in the pathogenesis and progression of human diseases, particularly NDs. Herbal medicine has been used for centuries to treat human diseases, including NDs. These compounds help to relieve symptoms and delay the progression of NDs by improving intestinal barrier function, reducing neuroinflammation, and modulating neurotransmitter production. Notably, herbal medicine can mitigate the progression of NDs by regulating the gut microbiota. Therefore, an in-depth understanding of the potential mechanisms by which herbal medicine regulates the gut microbiota in the treatment of NDs can help explain the pathogenesis of NDs from a novel perspective and propose novel therapeutic strategies for NDs. In this review, we investigate the potential neuroprotective effects of herbal medicine, focusing on its ability to regulate the gut microbiota and restore homeostasis. We also highlight the challenges and future research priorities of the integration of herbal medicine and modern medicine. As the global population ages, access to this information is becoming increasingly important for developing effective treatments for these diseases.

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Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

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“…A subtler but no less effective strategy to modify the gut microbiota is through modulatory approaches by prebiotics or dietary compounds [ 97 , 98 ]. Consumption of oligo-fructose enriched inulin increased the abundance of Bifidobacterium species and of C. scindens (7α-dehydroxylase activity) and decreased the abundance of Bacteroides vulgatus (BSH activity and putative 7α-dehydroxylase activity), but had no effect on the fecal bile acid pool in overweight children [ 99 ].…”

Section: Strategies To Modulate the Bile Acid Poolmentioning

confidence: 99%

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Gillard

Leclercq

2023

Clinical Science

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Bile acids synthesized within the hepatocytes are transformed by gut microorganisms and reabsorbed into the portal circulation. During their enterohepatic cycling, bile acids act as signaling molecules by interacting with receptors to regulate pathways involved in many physiological processes. The bile acid pool, composed of a variety of bile acid species, has been shown to be altered in diseases, hence contributing to disease pathogenesis. Thus, understanding the changes in bile acid pool size and composition in pathological processes will help to elaborate effective pharmacological treatments. Five crucial steps along the enterohepatic cycle shape the bile acid pool size and composition, offering five possible targets for therapeutic intervention. In this review, we provide an insight on the strategies to modulate the bile acid pool, and then we discuss the potential benefits in non-alcoholic fatty liver disease.

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“…These have attracted extensive attention due to their important roles in the occurrence and development of obesity and related metabolic diseases. 8,9 Diet and the gut microbiota interact with BAs pools through biotransformation reactions, thereby influencing the hydrophobicity, toxicity, and regulatory effects of BAs. 10 There are numerous treatment options available for overweight and obesity, including dietary interventions, prescription weight-loss drugs, and bariatric surgery.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

Li,

Zhang,

Tan

et al. 2024

Natural Product Communications

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Objectives Female obesity may be improved by the consumption of a high-polyphenolic-rich diet. Lycium ruthenicum Murray is a renowned edible plant, the fruit of which is abundant in anthocyanins and exhibits many biological activities. This study aimed to investigate the potential impact of anthocyanins derived from Lycium ruthenicum Murray (ACN) intervention on improving obesity by regulating the gut microbiota and bile acids (BAs) metabolism in high-fat diet (HFD)-induced female mice. Methods A total of 32 C57BL/6J female mice were divided into four distinct groups: the Ctrl group (fed a normal diet), Ctrl + ACN group (fed a normal diet plus 8 mg/mL extract of ACN), HFD group (fed a high-fat diet), and HFD + ACN group (fed a HFD plus 8 mg/mL extract of ACN). Results The findings showed that ACN significantly reduced the body weight, periovarian adipose mass, and adipocyte diameter, ameliorated lipid accumulation in the liver, and lowered the serum total cholesterol and low-density lipoprotein (LDL-C) levels in HFD-induced female mice. In addition, ACN exhibited a reversal of gut microbial dysbiosis in HFD-fed female mice, such as by enhancing the quantity of Lactobacillus and Allobaculum and reducing the abundance of Blautia and Faecalibaculum. Moreover, the results of fecal BAs showed that ACN led to a decrease in the ratio of primary to secondary BAs, mainly attributed to decreased levels of primary BAs, including CA, CDCA, αMCA, and HCA in HFD-induced female mice. Further analysis revealed that ACN may exert its anti-obesity effect by increasing the relative abundance of Lactobacillus_ jonsonii and Lactobacillus_reuteri within the gut and subsequently affecting the metabolism of fecal HDCA and GUDCA. Conclusion These results indicated that ACN effectively inhibits HFD-induced obesity in female mice by regulating gut microbiota-related BA metabolism.

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Gut microbiota, bile acids, and nature compounds

Cited by 11 publications

References 144 publications

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

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