Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders

Li, Longyan; Liang, Tingting; Jiang, Tong; Liu, Ying; Yang, Lingshuang; Wu, Lei; Yang, Juan; Ding, Yu; Wang, Juan; Chen, Moutong; Zhang, Jumei; Xie, Xinqiang; Wu, Qingping

doi:10.1080/10408398.2023.2228409

Cited by 5 publications

(1 citation statement)

References 180 publications

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“…In recent years, the gut-brain axis has attracted increasing attention, with gut microbiota and their metabolites playing a crucial role. Current research suggests that gut microbiota and their metabolites can regulate the autonomic nervous system, endocrine system, and immune system, influence the release of neurotransmitters, and affect the activity of the central nervous system, thereby influencing sleep ( 26 , 27 ). Furthermore, probiotic supplements can enhance physical performance.…”

Section: Discussionmentioning

confidence: 99%

Association between dietary live microbe intake and Life's Essential 8 in US adults: a cross-sectional study of NHANES 2005–2018

Wang,

Wang

et al. 2024

Front. Nutr.

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BackgroundAssessing the impact of dietary live microbe intake on health outcomes has gained increasing interest. This study aimed to elucidate the relationship between dietary live microbe intake and Life's Essential 8 (LE8) scores, a metric for cardiovascular health (CVH), in the U.S. adult population.MethodsWe analyzed data from 10,531 adult participants of the National Health and Nutrition Examination Survey (NHANES) spanning 2005–2018. Participants were stratified into low, medium, and high intake groups of dietary live microbe based on Marco's classification system. We employed weighted logistic and linear regression analyses, along with subgroup, interaction effect, and sensitivity analyses. Additionally, Restricted Cubic Splines (RCS) were used to explore the dose-response relationship between food intake and CVH in different groups.ResultsCompared to the low live microbe intake group, the medium and high live microbe intake groups had significantly higher LE8, with β coefficients of 2.75 (95% CI: 3.89–5.65) and 3.89 (95% CI: 6.05–8.11) respectively. Additionally, moderate and high groups significantly reduced the risk of high cardiovascular health risk, defined as an LE8 score below 50, with odds ratios (OR) of 0.73 and 0.65 respectively. Subgroup analysis and sensitivity analysis proved the stability of the results. In the low intake group, food intake shows a linear negative correlation with LE8, whereas in the high intake group, it exhibits a linear positive correlation. In contrast, in the moderate live microbe intake group, the relationship between food intake and LE8 presents a distinct inverted “U” shape.ConclusionThis study highlights the potential benefits of medium to high dietary intake of live microbe in improving LE8 scores and CVH in adults. These findings advocate for the inclusion of live microbes in dietary recommendations, suggesting their key role in CVH enhancement.

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Section: Discussionmentioning

confidence: 99%

Association between dietary live microbe intake and Life's Essential 8 in US adults: a cross-sectional study of NHANES 2005–2018

Wang,

Wang

et al. 2024

Front. Nutr.

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Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice

Lee,

Hwang,

Ham

et al. 2024

ACS Omega

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The human gut microbiota significantly influences various physiological systems, including immune, nervous, and metabolic systems. Recent studies suggest that gut microbiota may affect sleep quality with certain bacteria and metabolites being linked to sleep patterns. However, the underlying chemical signaling pathway remains unclear. In this study, we investigated the effect of four gut bacteria-derived metabolites, tryptamine (1), indolokine A5 (2), 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE, 3), and phenethylamine (PEA, 4), on sleep characteristics in mice and melatonin biosynthesis pathways in zebrafish. Their sleep-promoting effects were evaluated in a pentobarbital-induced sleep mouse model, revealing significant increases in sleep duration and blood melatonin levels, particularly with ITE (3) and PEA (4). Further tests in zebrafish embryos showed that ITE (3) and PEA (4) increased the expression of genes for melatonin biosynthesis (Aanat1, Aanat2, Tph1a, and Hiomt) in a concentration-dependent manner, indicating their potential as therapeutic agents for sleep disorders.

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Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects

Lin,

Jiang,

Chen

et al. 2024

Open Life Sciences

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Sleep is crucial for wellness, and emerging research reveals a profound connection to gut microbiota. This review explores the bidirectional relationship between gut microbiota and sleep, exploring the mechanisms involved and the therapeutic opportunities it presents. The gut–brain axis serves as a conduit for the crosstalk between gut microbiota and the central nervous system, with dysbiosis in the microbiota impairing sleep quality and vice versa. Diet, circadian rhythms, and immune modulation all play a part. Specific gut bacteria, like Lactobacillus and Bifidobacterium, enhance sleep through serotonin and gamma-aminobutyric acid production, exemplifying direct microbiome influence. Conversely, sleep deprivation reduces beneficial bacteria, exacerbating dysbiosis. Probiotics, prebiotics, postbiotics, and fecal transplants show therapeutic potential, backed by animal and human research, yet require further study on safety and long-term effects. Unraveling this intricate link paves the way for tailored sleep therapies, utilizing microbiome manipulation to improve sleep and health. Accelerated research is essential to fully tap into this promising field for sleep disorder management.

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Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders

Cited by 5 publications

References 180 publications

Association between dietary live microbe intake and Life's Essential 8 in US adults: a cross-sectional study of NHANES 2005–2018

Association between dietary live microbe intake and Life's Essential 8 in US adults: a cross-sectional study of NHANES 2005–2018

Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice

Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects

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