Gut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women

Huang, Lihui; Cai, Min; Li, Li; Zhang, Xin; Xu, Yang; Xiao, Jianhua; Huang, Qian; Luo, Guijuan; Zeng, Zhaoyang; Jin, Cuiyuan; Jin, Yuanxiang; He, Jun; Yang, Weitao

doi:10.1186/s12866-021-02327-7

Cited by 37 publications

(32 citation statements)

References 49 publications

(64 reference statements)

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“…A number of observational studies have reported the association between gut microbiota and PE [ 16 – 19 , 43 – 46 ]. Bifidobacterium was found to be associated with a lower risk of PE, which is consistent with the results of our study [ 18 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Wang

Guo

et al. 2022

BMC Med

267

138

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Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown. Methods A two-sample Mendelian randomization study was performed using the summary statistics of gut microbiota from the largest available genome-wide association study meta-analysis (n=13,266) conducted by the MiBioGen consortium. The summary statistics of preeclampsia-eclampsia were obtained from the FinnGen consortium R7 release data (5731 cases and 160,670 controls). Inverse variance weighted, maximum likelihood, MR-Egger, weighted median, weighted model, MR-PRESSO, and cML-MA were used to examine the causal association between gut microbiota and preeclampsia-eclampsia. Reverse Mendelian randomization analysis was performed on the bacteria that were found to be causally associated with preeclampsia-eclampsia in forward Mendelian randomization analysis. Cochran’s Q statistics were used to quantify the heterogeneity of instrumental variables. Results Inverse variance weighted estimates suggested that Bifidobacterium had a protective effect on preeclampsia-eclampsia (odds ratio = 0.76, 95% confidence interval: 0.64–0.89, P = 8.03 × 10−4). In addition, Collinsella (odds ratio = 0.77, 95% confidence interval: 0.60–0.98, P = 0.03), Enterorhabdus (odds ratio = 0.76, 95% confidence interval: 0.62–0.93, P = 8.76 × 10−3), Eubacterium (ventriosum group) (odds ratio = 0.76, 95% confidence interval: 0.63–0.91, P = 2.43 × 10−3), Lachnospiraceae (NK4A136 group) (odds ratio = 0.77, 95% confidence interval: 0.65–0.92, P = 3.77 × 10−3), and Tyzzerella 3 (odds ratio = 0.85, 95% confidence interval: 0.74–0.97, P = 0.01) presented a suggestive association with preeclampsia-eclampsia. According to the results of reverse MR analysis, no significant causal effect of preeclampsia-eclampsia was found on gut microbiota. No significant heterogeneity of instrumental variables or horizontal pleiotropy was found. Conclusions This two-sample Mendelian randomization study found that Bifidobacterium was causally associated with preeclampsia-eclampsia. Further randomized controlled trials are needed to clarify the protective effect of probiotics on preeclampsia-eclampsia and their specific protective mechanisms.

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Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Wang

Guo

et al. 2022

BMC Med

267

138

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“…Due to significant pathogenetic heterogeneity, no reliable biomarkers or clinical trials could predict the occurrence of PE during early pregnancy. Moreover, timely termination of pregnancy is the only effective treatment of PE to date, highlighting the significance of early diagnosis and treatment for improving the prognosis of PE (5). The International Federation of Gynecology and Obstetrics (FIGO) suggested that maternal risk factors, including maternal age, obesity, and family history along with biomarkers, could efficiently predict the risk of PE.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Potential of Gut Microbiota-Derived Short-Chain Fatty Acids in Preeclampsia

Wang²,

Chen³

et al. 2022

Front. Pediatr.

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Preeclampsia (PE) is a complex pregnancy-related hypertensive disorder leading to multiorgan dysfunction. It has high maternal, fetal, and neonatal morbidity and mortality rates. The study of gut microbiota and its metabolites in PE deserves further exploration. Thirty-eight pregnant women with PE and 29 healthy pregnant women in the third trimester of their pregnancy were recruited in this study. We used a targeted metabolomics approach to evaluate the short-chain fatty acids (SCFAs) in serum samples. The correlation between SCFAs and clinical characteristics was also explored. The results of mass spectrometry (MS) showed significant differences at the metabolomics level of SCFAs between the PE and healthy control. The metabolic levels of acetate, propionate, isobutyrate, and valerate were significantly increased in the PE group than in the healthy control group. In contrast, caproic acid and butyrate levels were significantly reduced. The correlation analysis showed that urea, systolic, and diastolic blood pressure levels were positively correlated with four types of SCFAs (acetic acid, propionic acid, isobutyric acid, and valeric acid) which increased in the PE group. Furthermore, the neutrophil percentage and the fetal birth weight were negatively correlated with isobutyric acid and valeric acid. In addition, the receiver operating characteristic (ROC) analysis using a generalized linear model showed that multiple SCFAs would be potential diagnostic markers for PE, with high specificity, sensitivity, and area under the curve (AUC). Among them, isobutyric acid (sensitivity: 97.4%, specificity: 100%, AUC = 1.00), propionic acid (sensitivity: 86.8%, specificity: 93.3%, AUC = 0.954) and acetic acid (sensitivity: 86.8%, specificity: 83.3%, AUC = 0.891) depicted significantly higher diagnostic value and potential clinical applications. In summary, the results of this study indicate that SCFAs have the potential to become effective biomarkers for early screening of PE.

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“…Sterile sampling of the human placenta is difficult to obtain. Leiby et al also suspected that the evidence for the existence of the placental microbiome is not scientifically reliable [ 40 ]. To be able to test it, it would be necessary to develop a method of collecting the material that does not raise ethical dilemmas and is carried out in sterile conditions, eliminating the possibility of pre-laboratory errors [ 41 ].…”

Section: Possible Beginning Of the Formation Of The Intestinal Microb...mentioning

confidence: 99%

“…In a study of 100 women, 26 were pregnant with preeclampsia, 25 had abnormal growth of the placenta, 21 were healthy non-pregnant women, and 28 were healthy pregnant women. A significant reduction in the abundance of Prevotella, Porphyromonas, Varibaculum, and Lactobacillus was observed in women with preeclampsia compared to pregnant women without this complication [ 40 ]. Prevotella is a bacterium that exerts many functions in the human gastrointestinal tract [ 48 ].…”

Section: Gut Microbiome and Preeclampsiamentioning

confidence: 99%

“…The study also included toxins produced by Lactobacillus OTU255 and OTU784, where OTU255 was significantly reduced in the group of individuals with preeclampsia, while OTU784 decreased significantly in patients with abnormal placental growth. The analysis of the obtained results allows us to draw conclusions about the importance of changes in the microorganisms inhabiting the gastrointestinal tract in the etiology of both preeclampsia and abnormal growth of the placenta during pregnancy [ 40 ]. Lactobacillus is one of the most popular probiotics used worldwide as an additive in processed foods and drug development [ 56 ].…”

Section: Gut Microbiome and Preeclampsiamentioning

confidence: 99%

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Changes in the Gut Microbiome and Pathologies in Pregnancy

GORCZYCA

Obuchowska

Kimber-Trojnar

et al. 2022

IJERPH

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Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora.

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Gut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women

Cited by 37 publications

References 49 publications

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

The Diagnostic Potential of Gut Microbiota-Derived Short-Chain Fatty Acids in Preeclampsia

Changes in the Gut Microbiome and Pathologies in Pregnancy

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