Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus

Ding, Liang; Xiao, Xinhua

doi:10.1097/cm9.0000000000000702

Cited by 13 publications

(15 citation statements)

References 90 publications

(143 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement, alterations in circadian systems may contribute to obesity-related complications in humans, including T2D and hypertension (29)(30)(31)(32)(33)(34)(35)(36). In recent years, several studies have unveiled a functional interaction between circadian rhythms and the gut microbiome that may influence host metabolism and glucose homeostasis (37)(38)(39)(40). The gut microbiome itself has been shown to be an important player in the development of obesity and T2D (41-43).…”

Section: Discussionmentioning

confidence: 91%

A time-restricted feeding intervention in children and adolescents with obesity: The TRansForm study protocol

Molina-Giraldo

Murillo²,

Meis³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Obesity during childhood is of special concern as adiposity is typically tracked into adult life and it constitutes a major risk factor for future obesity and associated metabolic disorders. Recent studies indicate that time-restricted feeding (TRF) interventions may provide a promising strategy for obesity treatment. However, TRF interventions have only been tested in adult subjects. This study aims to determine both short- and long-term effects of a TRF intervention in children and adolescents with obesity. We will also investigate potential mechanisms mediating the response to the intervention, including the circadian rhythm and the gut microbiota composition. We have designed a randomized-controlled parallel-group clinical study in which children and adolescents (age range 8–18 year-old) with obesity will be subjected to time-restricted eating or no time restrictions for 2 months. Follow-up visits will allow for long-term effect assessments. We will measure anthropometric (BMI, body composition) and metabolic parameters (glucose and lipid metabolism), indicators of the circadian rhythm, and gut microbiota composition will be analyzed. This study will (1) determine safety and effectiveness of the TRF intervention in children and adolescents; (2) assess its long-term effects; and (3) evaluate potential mechanisms involved in the response to the intervention.Clinical trial registration[www.ClinicalTrials.gov], identifier [NCT05174871].

show abstract

Section: Discussionmentioning

confidence: 91%

A time-restricted feeding intervention in children and adolescents with obesity: The TRansForm study protocol

Molina-Giraldo

Murillo²,

Meis³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Adhesion of probiotics to the intestinal mucosa also increases, which is a favorable factor for the interaction between probiotic bacteria and the host during intestinal colonization [ 82 ]. Dysbiosis of the intestinal microbiota community structure is correlated with several intestinal diseases and metabolic disorders, such as inflammatory bowel disease, constipation, diabetes and obesity [ 83 , 84 , 85 ]. Probiotics also have positive implications in the alleviation of diseases caused by intestinal microbial imbalances.…”

Section: The Site Of Action Of Probiotics and Their Corresponding Dos...mentioning

confidence: 99%

Characteristics of Probiotic Preparations and Their Applications

Wang

Chen

Xia

et al. 2022

Foods

View full text Add to dashboard Cite

The probiotics market is one of the fastest growing segments of the food industry as there is growing scientific evidence of the positive health effects of probiotics on consumers. Currently, there are various forms of probiotic products and they can be categorized according to dosage form and the site of action. To increase the effectiveness of probiotic preparations, they need to be specifically designed so they can target different sites, such as the oral, upper respiratory or gastrointestinal tracts. Here we review the characteristics of different dosage forms of probiotics and discuss methods to improve their bioavailability in detail, in the hope that this article will provide a reference for the development of probiotic products.

show abstract

“…Furthermore, the perception “Developmental Origins of Health and Disease” (DOHaD), evolved from the “thrifty phenotype” explanation created by Barker in 1992, claimed that it is in the very early life, the stage of gestation, during which unfavorable environmental exposure can robustly pose a high incidence of chronic metabolism disorders, such as diabetes, obesity, dyslipidemia, etc., which persist in offspring into adulthood and even through generations [ 9 , 10 , 11 ]. Such an effect is brought about through epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding RNAs [ 12 ], by altered intrauterine environment factors, including maternal nutrition status [ 13 ], lack of physical activities [ 13 , 14 ], circadian dysregulation [ 15 ], psychological stress [ 16 ], and tobacco smoking [ 17 ] during gestation.…”

Section: Introductionmentioning

confidence: 99%

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Zeng

Zhang

et al. 2023

Nutrients

View full text Add to dashboard Cite

Currently, vitamin D (VD) deficiency during pregnancy is widespread globally, causing unfavorable pregnancy outcomes for both mothers and infants for a longer time than expected, based on the Developmental Origins of Health and Disease (DOHaD) theory. As VD plays a key role in maintaining normal glucose and lipid metabolism, maternal VD deficiency may lead to obesity and other obesity-related diseases among offspring later in life. This review mainly focuses on the effect of maternal VD deficiency on offspring lipid metabolism, reviewing previous clinical and animal studies to determine the effects of maternal VD deficit on offspring obesity and potential mechanisms involved in the progression of offspring obesity. Emerging clinical evidence shows that a low VD level may lead to abnormal growth (either growth restriction or largeness for gestational age) and lipid and glucose metabolism disorders in offspring. Here, we also outline the link between maternal VD deficiency and life-long offspring effects, including the disorder of adipogenesis, the secretion of adipocytokines (including leptin, resistin, and adiponectin), activated systemic inflammation, increased oxidative reactions in adipose tissue, insulin resistance, and abnormal intestinal gut microbiota. Thus, there is an urgent need to take active steps to address maternal VD deficiency to relieve the global burden of obesity.

show abstract

Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus

Cited by 13 publications

References 90 publications

A time-restricted feeding intervention in children and adolescents with obesity: The TRansForm study protocol

A time-restricted feeding intervention in children and adolescents with obesity: The TRansForm study protocol

Characteristics of Probiotic Preparations and Their Applications

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Contact Info

Product

Resources

About