Gut microbiota composition explains more variance in the host cardiometabolic risk than genetic ancestry

Guzmán-Castañeda, Sandra J; Ortega-Vega, Esteban L; Cuesta-Zuluaga, Jacobo de la; Velásquez-Mejía, Eliana P.; Rojas, Winston; Bedoya, Gabriel; Escobar, Juan S.

doi:10.1080/19490976.2019.1634416

Cited by 15 publications

(4 citation statements)

References 62 publications

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“…In the last 10 years, it has been observed that there is a possible relationship between the intestinal microbiota and the cardiovascular system [11,144,182,183]. Human cardiometabolic health has been related with variations in the gut microbiota composition (dysbiosis) [184]. Kelly et al reported that subjects with a high lifetime burden of CVD risk factors had less microbial wealth compared to those with a low lifetime burden, identifying a high number of Bacteroidetes and Firmicutes [185].…”

Section: Physical Activity Microbiota and Cardiovascular Diseasesmentioning

confidence: 99%

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

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The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.

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Section: Physical Activity Microbiota and Cardiovascular Diseasesmentioning

confidence: 99%

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

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“…A similar analysis on the supplemental data of a Korean cohort reveals the exact same RCM cluster to be correlated with these MetS components [ 49 ]. Other studies also mentioned negative associations between Christensenellaceae , Ruminococcaceae , Methanobrevibacter , and Tenericutes with MetS and/or its components [ 33 , 46 , 48 , 50 ]. The study of Ruaud et al (2020) shows that this cooccurrence between Christensenellaceae and Methanobrevibacter is functional rather than just due to shared environmental preferences [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Ethnic variations in metabolic syndrome components and their associations with the gut microbiota: the HELIUS study

Balvers,

de Goffau,

van Riel

et al. 2024

Genome Med

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Background The occurrence of metabolic syndrome (MetS) and the gut microbiota composition are known to differ across ethnicities yet how these three factors are interwoven is unknown. Also, it is unknown what the relative contribution of the gut microbiota composition is to each MetS component and whether this differs between ethnicities. We therefore determined the occurrence of MetS and its components in the multi-ethnic HELIUS cohort and tested the overall and ethnic-specific associations with the gut microbiota composition. Methods We included 16,209 treatment naïve participants of the HELIUS study, which were of Dutch, African Surinamese, South-Asian Surinamese, Ghanaian, Turkish, and Moroccan descent to analyze MetS and its components across ethnicities. In a subset (n = 3443), the gut microbiota composition (16S) was associated with MetS outcomes using linear and logistic regression models. Results A differential, often sex-dependent, prevalence of MetS components and their combinations were observed across ethnicities. Increased blood pressure was commonly seen especially in Ghanaians, while South-Asian Surinamese and Turkish had higher MetS rates in general and were characterized by worse lipid-related measures. Regarding the gut microbiota, when ethnic-independent associations were assumed, a higher α-diversity, higher abundance of several ASVs (mostly for waist and triglyceride-related outcomes) and a trophic network of ASVs of Ruminococcaceae, Christensenellaceae, and Methanobrevibacter (RCM) bacteria were associated with better MetS outcomes. Statistically significant ethnic-specific associations were however noticed for α-diversity and the RCM trophic network. Associations were significant in the Dutch but not always in all other ethnicities. In Ghanaians, a higher α-diversity and RCM network abundance showed an aberrant positive association with high blood pressure measures compared to the other ethnicities. Even though adjustment for socioeconomic status-, lifestyle-, and diet-related variables often attenuated the effect size and/or the statistical significance of the ethnic-specific associations, an overall similar pattern across outcomes and ethnicities remained. Conclusions The occurrence of MetS characteristics among ethnicities is heterogeneous. Both ethnic-independent and ethnic-specific associations were identified between the gut microbiota and MetS outcomes. Across multiple ethnicities, a one-size-fits-all approach may thus be reconsidered in regard to both the definition and/or treatment of MetS and its relation to the gut microbiota.

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“…The host’s cardiometabolic diseases and brain disease risk is associated with the alternation of bacterial community composition 40 , 41 . In the present study, obvious shifting patterns in the gut microbiota composition were observed in preterm neonates’ stool samples collected in their first 4 weeks of stay in NICU.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization

Chen

Maas

et al. 2022

Interdisciplinary Nursing Research

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Objectives: The gut microbiota among preterm infants is shaped by sex and feeding types. However, sex-specific weekly patterns of gut microbiome profiles among preterm infants during their neonatal intensive care unit (NICU) hospitalization remain unclear. This study aimed to investigate the effect of sex on the weekly development of preterm neonatal gut microbiota in the first 4 weeks of NICU hospitalization. Methods: This secondary data analysis included 28 preterm neonates with 261 stool samples collected from January 2014 to February 2015 in the Northeastern United States. The 16S rRNA V4 gene regions of the stool samples were sequenced and aligned against the SILVA 132 database by using Mothur 1.42.3. The sex-specific weekly diversity indexes and relative abundance of bacterial taxonomic composition were generated by Mothur and analyzed by R packages. Sex-specific weekly compositional patterns of the gut microbiome and predicted metabolic functions of gut microbiome profiles were compared, respectively. Results: In each week of the NICU hospitalization, preterm females and males had significantly distinguished β-diversity indices and compositions of gut microbiota. Both females and males had significantly enriched Bifidobacterium, a protection feature, in stool samples collected in the third week compared with those in the second week. The predicted metabolic pathways were significantly different between females and males in the second, third, and fourth week of the NICU hospitalization. Both females and males had significantly abundant pathways. Males consistently had more abundance of "lipopolysaccharide biosynthesis" than females in the second, third, and fourth week. Males also had a significant abundance of "membrane and intracellular structural molecules" and "glycan biosynthesis and metabolism" in the second and third week. Conclusions: Sex shaped the weekly patterns of preterm neonatal gut microbiome profiles during the first 4 weeks of the NICU hospitalization. Further clinical interventions should consider the distinct gut microbiota compositions and predicted functional profiles between female and male preterm neonates.

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Gut microbiota composition explains more variance in the host cardiometabolic risk than genetic ancestry

Cited by 15 publications

References 62 publications

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

Ethnic variations in metabolic syndrome components and their associations with the gut microbiota: the HELIUS study

Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization

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