Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma

Gong, Hui; Zhang, Simin; Li, Qiguan; Chen, Zuo; Gao, Xinbo; Zheng, Bingru; Lin, Mingkai

doi:10.1016/j.exer.2020.107921

Cited by 95 publications

(78 citation statements)

References 35 publications

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“…Primary open-angle glaucoma (POAG) is an ocular neurodegenerative disease characterized by loss of retinal ganglion cells which causes irreversible blindness and affects approximately 79.6 million people worldwide [77]. A recent study by Gong et al found that the gut microbiota of subjects with POAG, compared to healthy subjects, had increased abundance of Prevotellaceae, Enterobacteriaceae, and Escherichia coli and decreased abundance of Megamonas and Bacteroides plebeius [78]. Furthermore, they found that mean visual acuity was negatively correlated with bacteria of the Megamonas genus, visual field mean defect (VF-MD) was negatively correlated with members of the Faecalibacterium genus, and average retinal nerve fiber layer (RNFL) thickness was positively correlated with members of the Streptococcus genus.…”

Section: Glaucomamentioning

confidence: 99%

“…Furthermore, they found that mean visual acuity was negatively correlated with bacteria of the Megamonas genus, visual field mean defect (VF-MD) was negatively correlated with members of the Faecalibacterium genus, and average retinal nerve fiber layer (RNFL) thickness was positively correlated with members of the Streptococcus genus. [ 78 ] In a study of 1999 African American subjects (1217 with POAG and 782 controls), Collins et al found that variants in two mitochondrial DNA (mtDNA) haplogroups, L2a1 (m.15784T>C) and L2 haplogroups (m.16390G>A), were enriched in DNA pools of POAG subjects compared to controls [ 79 ]. These variants were associated with the composition of the gut microbiota.…”

Section: The Gut Microbiota In Models Of Ocular Diseasesmentioning

confidence: 99%

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The Gut–Eye Axis: Lessons Learned from Murine Models

Floyd

Grant

2020

Ophthalmol Ther

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A healthy gut microbiota is essential in maintaining the human body in a homeostatic state by its functions in digestion and immune tolerance. Under states of aberrant microbial composition or function (dysbiosis), the gut microbiota induces systemic inflammation that can lead to the onset of many diseases. In this review, we describe some evidence, largely from rodent studies, that supports the possible role of a dysbiotic gut microbiota in the onset and exacerbation of ocular diseases, primarily diabetic retinopathy, age-related macular degeneration, choroidal neovascularization, and uveitis. Furthermore, we examine several potential therapeutic measures that show promise in restoring the gut microbiota to a eubiotic state, preventing the aforementioned disease pathologies.

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Section: Glaucomamentioning

confidence: 99%

Section: The Gut Microbiota In Models Of Ocular Diseasesmentioning

confidence: 99%

The Gut–Eye Axis: Lessons Learned from Murine Models

Floyd

Grant

2020

Ophthalmol Ther

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“…The study demonstrated that T cells at least partially mediated the glaucomatous pathology in DBA/2J mice raised under specific-pathogen-free conditions (88). A more recent study found that compared to healthy subjects, the gut microbiota of patients with primary open-angle glaucoma had a different gut microbiota profile (89).…”

Section: Ocular Inflammatory Diseases Are Associated With Non-ocular mentioning

confidence: 94%

Ocular Microbiota and Intraocular Inflammation

Wei

2020

Front. Immunol.

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The term ocular microbiota refers to all types of commensal and pathogenic microorganisms present on or in the eye. The ocular surface is continuously exposed to the environment and harbors various commensals. Commensal microbes have been demonstrated to regulate host metabolism, development of immune system, and host defense against pathogen invasion. An unbalanced microbiota could lead to pathogenic microbial overgrowth and cause local or systemic inflammation. The specific antigens that irritate the deleterious immune responses in various inflammatory eye diseases remain obscure, while recent evidence implies a microbial etiology of these illnesses. The purpose of this review is to provide an overview of the literature on ocular microbiota and the role of commensal microbes in several eye diseases. In addition, this review will also discuss the interaction between microbial pathogens and host factors involved in intraocular inflammation, and evaluate therapeutic potential of targeting ocular microbiota to treat intraocular inflammation.

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“…Moreover, the retina re ects some of the pathological alterations of many neurodegenerative diseases, and may provide information of brain pathology severity 31,32 . In this context, a few recent studies have linked gut microbiome changes with some retinal degenerative diseases 33,34 , including age-related macular degeneration (AMD) [35][36][37][38][39] , glaucoma [40][41][42][43] and diabetic retinopathy 44 , even though the published results vary depending on the type and stage of the disease and between studies. On the other hand, in a previous study we have demonstrated that invasive infection from gastrointestinal microbiome can induce activation of retinal microglia 45 , the primary resident immune cell of the retina.…”

Section: Introductionmentioning

confidence: 99%

Retinitis Pigmentosa is Associated With Shifts in The Gut Microbiome

Kutsyr

Maestre‐Carballa

Lluesma-Gomez

et al. 2020

Preprint

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The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP). Here, we investigated changes in gut microbiome composition linked to RP, by assessing both retinal degeneration and gut microbiome in the rd10 mouse model of RP as compared to control C57BL/6J mice. In rd10 mice, retinal responsiveness to flashlight stimuli and visual acuity were deteriorated with respect to observed in age-matched control mice. This functional decline in dystrophic animals was accompanied by photoreceptor loss, morphologic anomalies in photoreceptor cells and retinal reactive gliosis. Furthermore, 16S rRNA gene amplicon sequencing data showed a microbial gut dysbiosis with differences in alpha and beta diversity at the genera, species and amplicon sequence variants (ASV) levels between dystrophic and control mice. Remarkably, four fairly common ASV in healthy gut microbiome belonging to Rikenella spp., Muribaculaceace spp., Prevotellaceae UCG-001 spp., and Bacilli spp. were absent in the gut microbiome of retinal disease mice, while Bacteroides caecimuris was significantly enriched in mice with RP. The results indicate that retinal degenerative changes in RP are linked to relevant gut microbiome changes. The findings suggest that microbiome shifting could be considered as potential biomarker and therapeutic target for retinal degenerative diseases.

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Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma

Cited by 95 publications

References 35 publications

The Gut–Eye Axis: Lessons Learned from Murine Models

The Gut–Eye Axis: Lessons Learned from Murine Models

Ocular Microbiota and Intraocular Inflammation

Retinitis Pigmentosa is Associated With Shifts in The Gut Microbiome

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