Gut Microbiota Compositions and Modulation of Bacterial Metabolic Functional Genes in Type -2 Diabetes Mellitus Individuals at Nnewi, Anambra State, Nigeria

Oshim, Ifeanyi Onyema; Agbakoba, Nneka Regina; Oguejiofor, Ogbonna Celestine

doi:10.5281/zenodo.4050381

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“…Additionally, studies have shown that Romboutsia is negatively correlated with fasting glucose, insulin, and high-density lipoprotein cholesterol; and positively correlated with indicators of obesity [ 35 ]. Contrary to these findings, one study found a significantly lower relative abundance of R. timonensis in type 2 diabetes participants as compared to healthy controls [ 36 ]. Further, Hu et al (2019) reported that Romboutsia was reduced in the diabetic rats [ 37 ].…”

Section: Discussionmentioning

confidence: 83%

High-Resolution Taxonomic Characterization Reveals Novel Human Microbial Strains with Potential as Risk Factors and Probiotics for Prediabetes and Type 2 Diabetes

et al. 2023

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Alterations in the composition of the gut microbiota is thought to play a key role in causing type 2 diabetes, yet is not fully understood, especially at the strain level. Here, we used long-read DNA sequencing technology of 16S-ITS-23S rRNA genes for high-resolution characterization of gut microbiota in the development of type 2 diabetes. Gut microbiota composition was characterized from fecal DNA from 47 participants divided into 4 cohorts based on glycemic control: normal glycemic control (healthy; n = 21), reversed prediabetes (prediabetes/healthy; n = 8), prediabetes (n = 8), or type 2 diabetes (n = 10). A total of 46 taxa were found to be possibly related to progression from healthy state to type 2 diabetes. Bacteroides coprophilus DSM 18228, Bifidobacterium pseudocatenulatum DSM 20438, and Bifidobacterium adolescentis ATCC 15703 could confer resistance to glucose intolerance. On the other hand, Odoribacter laneus YIT 12061 may be pathogenic as it was found to be more abundant in type 2 diabetes participants than other cohorts. This research increases our understanding of the structural modulation of gut microbiota in the pathogenesis of type 2 diabetes and highlights gut microbiota strains, with the potential for targeted opportunistic pathogen control or consideration for probiotic prophylaxis and treatment.

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Section: Discussionmentioning

confidence: 83%