2021
DOI: 10.1186/s40168-021-01028-7
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Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Abstract: Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley leaf (BL) has a long history of use in Traditional Chinese Medicine with potential health-promoting effects on intestinal functions. However, its mechanism of action is not yet clear. Here, we explore the potential modulating roles of gut microbial metabolites of BL to protect against colitis and elucidate the underlying … Show more

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Cited by 139 publications
(108 citation statements)
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“…The BL was prepared as previously described [23] and its nutritional composition is shown in Supplementary Table S1. The contents of nutritional components including protein, fat, soluble dietary fiber, insoluble dietary fiber, moisture, and ash were detected based on the National Standard Test Method by PONY (Beijing, China).…”
Section: Nutritional Composition Of Blmentioning
confidence: 99%
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“…The BL was prepared as previously described [23] and its nutritional composition is shown in Supplementary Table S1. The contents of nutritional components including protein, fat, soluble dietary fiber, insoluble dietary fiber, moisture, and ash were detected based on the National Standard Test Method by PONY (Beijing, China).…”
Section: Nutritional Composition Of Blmentioning
confidence: 99%
“…Colonic slides were stained with hematoxylin and eosin (HE) to assess the extent of histological and crypt injury. In addition, colonic sections were also stained with Alcian blue (AB) to evaluate mucosal barrier damage by counting the goblet cells [23].…”
Section: Evaluation Of Histological Severitymentioning
confidence: 99%
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