Gut microbiota-derived metabolites in CRC progression and causation

Dalal, Nishu; Jalandra, Rekha; Bayal, Nitin; Yadav, Amit K.; Harshulika,; Sharma, Minakshi; Makharia, Govind; Kumar, Pramod; Singh, Rajeev; Solanki, Pratima R.; Kumar, Anil

doi:10.1007/s00432-021-03729-w

Cited by 66 publications

(45 citation statements)

References 145 publications

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“…As we all know, the microbiome cannot directly determine the creation of microbial metabolic products. The influence of a microbial interaction network and dynamic changes in microbial metabolites on CRC pathogenesis issues cannot be predicted by studying the involvement of a single microorganism in CRC pathogenesis (12,15). Thus, the potential significance of intestinal microbial metabolites in the etiology of CRC must be evaluated within the framework of metabolomics and gut microbiome association analysis, which is important in terms of the development of new strategies and medications to prevent and treat CRC.…”

Section: The Application Of Association Analysis Of Metabolomics and ...mentioning

confidence: 99%

“…Emerging studies have suggested that certain pathogens and/or microbial communities play a significant role in tumorigenesis by activating inflammatory pathways and aberrant epithelial cell proliferation, boosting tumorigenic immune responses, inducing DNA damage, and altering genome stability (10). Moreover, dysbiosis of the resident gut microbiota (rather than simply certain pathogens), particularly their metabolites, has been shown to significantly alter cancer risk or progression by causing immune response abnormalities or others (10)(11)(12). Furthermore, the reduction of several beneficial gut microflora metabolites, such as short-chain fatty acids (SCFAs), plays an important role in tumorigenesis and development.…”

Section: Introductionmentioning

confidence: 99%

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Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects

Zhang

et al. 2022

Front. Oncol.

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Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide. The etiology and pathogenesis of CRC remain unclear. A growing body of evidence suggests dysbiosis of gut bacteria can contribute to the occurrence and development of CRC by generating harmful metabolites and changing host physiological processes. Metabolomics, a systems biology method, will systematically study the changes in metabolites in the physiological processes of the body, eventually playing a significant role in the detection of metabolic biomarkers and improving disease diagnosis and treatment. Metabolomics, in particular, has been highly beneficial in tracking microbially derived metabolites, which has substantially advanced our comprehension of host-microbiota metabolic interactions in CRC. This paper has briefly compiled recent research progress of the alterations of intestinal flora and its metabolites associated with CRC and the application of association analysis of metabolomics and gut microbiome in the diagnosis, prevention, and treatment of CRC; furthermore, we discuss the prospects for the problems and development direction of this association analysis in the study of CRC. Gut microbiota and their metabolites influence the progression and causation of CRC, and the association analysis of metabolomics and gut microbiome will provide novel strategies for the prevention, diagnosis, and therapy of CRC.

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Section: The Application Of Association Analysis Of Metabolomics and ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects

Zhang

et al. 2022

Front. Oncol.

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“…The gut microbiome can influence the development of CRC in several ways. Perturbations in the gut microbiota expose the GIT to inflammatory and genotoxic metabolites such as secondary bile salts, trimethylamine-N-oxide (TMAO), hydrogen sulfide (from sulfur containing amino acids), heme, nitrosamines, heterocyclic amines, and polyaromatic hydrocarbons, often resulting from consumption of red or processed meat and diet poor in fibers ( 9 , 10 ). These dietary factors along with lifestyle factors such as smoking, alcohol and obesity increase the risk of oncogenic transformations in the colonic epithelial cells ( 1 ).…”

Section: Gut Microbiome and Colorectal Cancermentioning

confidence: 99%

“…Thus, the quality of diet delivered to the gut microbiota may be crucial for optimum health benefits. In the current era of processed food consumption, the gut biodiversity and chemical composition are profoundly affected, leading to chronic colonic inflammation, which increases the risk for CRC ( 9 , 10 , 66 , 67 ). Processed meat consumption is associated with the risk of developing colorectal malignancies.…”

Section: The Influence Of Diet On Gut Microbiome and Colorectal Cancer Developmentmentioning

confidence: 99%

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

et al. 2021

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Dietary factors have important role in modulating the gut microbiome, which in-turn regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome are decisive factors in colorectal cancer (CRC) tumorigenesis. Altered gut microbiome is associated with impaired immune response, and the release of carcinogenic or genotoxic substances which are the major microbiome-induced mechanisms implicated in CRC pathogenesis. Diets low in dietary fibers and phytomolecules as well as high in red meat are important dietary changes which predispose to CRC. Dietary fibers which reach the colon in an undigested form are further metabolized by the gut microbiome into enterocyte friendly metabolites such as short chain fatty acid (SCFA) which provide anti-inflammatory and anti-proliferative effects. Healthy microbiome supported by dietary fibers and phytomolecules could decrease cell proliferation by regulating the epigenetic events which activate proto-oncogenes and oncogenic pathways. Emerging evidence show that predominance of microbes such as Fusobacterium nucleatum can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. Synbiotics can protect the intestinal mucosa by improving immune response and decreasing the production of toxic metabolites, oxidative stress and cell proliferation. In this narrative review, we aim to update the emerging evidence on how diet could modulate the gut microbial composition and revive colonic epithelium. This review highlights the importance of healthy plant-based diet and related supplements in CRC prevention by improving the gut microbiome.

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“…The gut microbiome modulates host immunity [ 2 ] and protects the host against invading pathogens [ 3 ]. Recently, the microbiome has been linked to various diseases, such as ageing-related diseases [ 4 ], autism [ 5 ], cancer [ 6 , 7 ], gastrointestinal disorders [ 8 , 9 ], obesity and metabolic disorders [ 10 , 11 ]. The gut microbiome has recently been touted as a therapeutic target or as a drug target [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Large-Scale Meta-Longitudinal Microbiome Data with a Known Batch Factor

2022

Genes

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Data contamination in meta-approaches where multiple biological samples are combined considerably affects the results of subsequent downstream analyses, such as differential abundance tests comparing multiple groups at a fixed time point. Little has been thoroughly investigated regarding the impact of the lurking variable of various batch sources, such as different days or different laboratories, in more complicated time series experimental designs, for instance, repeatedly measured longitudinal data and metadata. We highlight that the influence of batch factors is significant on subsequent downstream analyses, including longitudinal differential abundance tests, by performing a case study of microbiome time course data with two treatment groups and a simulation study of mimic microbiome longitudinal counts.

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Gut microbiota-derived metabolites in CRC progression and causation

Cited by 66 publications

References 145 publications

Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects

Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Large-Scale Meta-Longitudinal Microbiome Data with a Known Batch Factor

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