Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

Zhang, Kaikai; Chen, Lijian; Yang, Jianzheng; Liu, Jiali; Li, Jiahao; Liu, Yi; Li, Xiuwen; Chen, Long; Hsu, Clare; Zeng, Jiahao; Xie, Xiaoli; Wang, Qi

doi:10.1016/j.apsb.2023.09.010

Cited by 25 publications

(1 citation statement)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that gut microbiota can affect the central nervous system and neurological and mental diseases (including anxiety disorders, depression, Parkinson's disease, etc.) through interactions with the gut-brain axis, and the composition of the gut microbiota in these patients is signi cantly different from that in healthy people [11][12][13][14]. Speci cally, the gut microbiota can interact with neurological, humoral and immunological components of the body in the gastrointestinal tract, thereby affecting the function and development of the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Causal Relationships between Gut Microbiota and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study

Fan,

Li,

Chen

2024

Preprint

View full text Add to dashboard Cite

Background Evidence shows that the composition of the gut microbiota (GM) is associated with depression and anxiety disorders. However, the causal relationship between them remains controversial. Methods To investigate the potential causal relationship between the gut microbiota and depression/anxiety disorders and to identify specific bacterial taxa, we conducted a two-sample Mendelian randomization (MR) analysis on the gut microbiome implicated in depression and anxiety disorders. We incorporated summary data from a genome-wide association study (GWAS) of the microbiome derived from 7,738 individuals participating in the Dutch Microbiome Project (DMP) as our exposure variable. Concurrently, the GWAS of depression and anxiety disorders was employed as our outcome variable. The principal estimates were procured using the inverse-variance weighted (IVW) test complemented by four robust methods: MR Egger, weighted median, simple mode, and weighted mode. In addition, we performed comprehensive sensitivity and directionality analyses. Results The results showed that 5 bacterial taxa were positively correlated with depression, 6 were negatively correlated; 5 were positively correlated with anxiety disorders, and 11 were negatively correlated. Conclusions This study provides new insights into the connection between the gut microbiota and the pathogenesis of depression and anxiety disorders and offers new perspectives for the diagnosis and treatment of these disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Causal Relationships between Gut Microbiota and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study

Fan,

Li,

Chen

2024

Preprint

View full text Add to dashboard Cite

show abstract

Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety

Wang,

Zhou

2024

Medicinal Research Reviews

View full text Add to dashboard Cite

Drug safety is a paramount concern in the field of drug development, with researchers increasingly focusing on the bidirectional regulation of gut microbiota in this context. The gut microbiota plays a crucial role in maintaining drug safety. It can influence drug transport processes in the body through various mechanisms, thereby modulating their efficacy and toxicity. The main mechanisms include: (1) The gut microbiota directly interacts with drugs, altering their chemical structure to reduce toxicity and enhance efficacy, thereby impacting drug transport mechanisms, drugs can also change the structure and abundance of gut bacteria; (2) bidirectional regulation of intestinal barrier permeability by gut microbiota, promoting the absorption of nontoxic drugs and inhibiting the absorption of toxic components; (3) bidirectional regulation of the expression and activity of transport proteins by gut microbiota, selectively promoting the absorption of effective components or inhibiting the absorption of toxic components. This bidirectional regulatory role enables the gut microbiota to play a key role in maintaining drug balance in the body and reducing adverse reactions. Understanding these regulatory mechanisms sheds light on novel approaches to minimize toxic side effects, enhance drug efficacy, and ultimately improve drug safety. This review systematically examines the bidirectional regulation of gut microbiota in drug transportation from the aforementioned aspects, emphasizing their significance in ensuring drug safety. Furthermore, it offers a prospective outlook from the standpoint of enhancing therapeutic efficacy and reducing drug toxicity, underscoring the importance of further exploration in this research domain. It aims to provide more effective strategies for drug development and treatment.

show abstract

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB

Zang,

Zhou,

et al. 2024

Eur J Nutr

View full text Add to dashboard Cite

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

Cited by 25 publications

References 76 publications

Causal Relationships between Gut Microbiota and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study

Causal Relationships between Gut Microbiota and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study

Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB

Contact Info

Product

Resources

About