Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women

Mörkl, Sabrina; Lackner, Sonja; Meinitzer, Andreas; Mangge, Harald; Lehofer, Michael; Halwachs, Bettina; Gorkiewicz, Gregor; Kashofer, Karl; Painold, Annamaria; Holl, Anna K.; Bengesser, S.; Müller, Wolfram; Holzer, Peter; Holasek, Sandra

doi:10.1007/s00394-018-1784-0

Cited by 111 publications

(73 citation statements)

References 60 publications

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“…Twenty‐four studies reported on 29 statistically significant biomarkers and association with altered IP . Two studies reported that fasting glucose had a weak positive correlation with IP (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the severity and activity of chronic health conditions including liver disease, metabolic syndrome, PCOS, coeliac disease and BMI were reported to correlate with the degree of IP. The notion that IP correlates with disease severity is further supported as the severity of particular risk factors also increase alongside the degree of IP . The involvement of IP in chronic disease, especially with advanced disease severity, highlights the potential importance of intestinal integrity in health and disease.…”

Section: Discussionmentioning

confidence: 96%

“…Ten studies reported a statistically significant association between 12 anthropometric measurements and IP. 10,23,42,51,[53][54][55][56][57][58] The correlation between BMI and IP ranged from a weak to moderate positive correlation, of which most were reported to have a weak positive correlation 23,44,51,55,56,59 (Table 5). Two studies report BMI as an independent risk factor for altered IP as measured by zonulin levels (β = 0.26; ±0.10; P < 0.05, β = 1.507; 0.34 SEM; P < 0.01) 51,54 ( 31.65; P = 0.047), respectively as measured by zonulin (>64 ng/mL) 23 ( Table 3).…”

Section: Anthropometric Risk Factorsmentioning

confidence: 99%

“…Twenty-four studies reported on 29 statistically significant biomarkers and association with altered IP. 10,23,25,32,35,[40][41][42][43][44][50][51][52][53][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] Two studies reported that fasting glucose had a weak positive correlation with IP 44,53 (Table 5). Moreover, an additional study reported that a plasma glucose level >5.7 nmol/L is associated with a greater odds of having altered IP (OR = 2.09; 95% CI: 2.09, 4.18; P = 0.036) in the general population 23 (Table 3).…”

Section: Biomarker Risk Factorsmentioning

confidence: 99%

“…61 Numerous inflammatory markers were measured in a total of 11 studies and were reported to have an association with IP. 41,44,51,53,56,57,[59][60][61]63,72 High-sensitivity C-Reactive protein (hsCRP) was reported to have a weak positive correlation IP 53,61,63 ( Table 5) with two studies also reporting that hsCRP correlates with IP as measured by zonulin (β = 0.013; 95% CI: 0.003, 0.023; P = 0.015, β = 0.075; 95% CI: 0.008, 0.158; P = 0.046) 53,61 (Table 4).…”

Section: Biomarker Risk Factorsmentioning

confidence: 99%

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Risk factors associated with intestinal permeability in an adult population: A systematic review

et al. 2019

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Background Increased intestinal permeability (IP) involves the loss of integrity between the cells of the small intestine. IP has been suggested to contribute to the pathogenesis and exacerbation of many chronic diseases. Many potential risk factors for IP are proposed in contemporary literature. The purpose of this review is to identify the most significant risk factors for IP. Methods A systematic search of literature published up until September 2018 in the PubMed, EMBASE, CINAHL, and Scopus databases was conducted. Results A total of 47 articles met the inclusion criteria. Elevated levels of proinflammatory markers, dyslipidaemia, hyperglycaemia, insulin resistance, anthropometric measurements resembling obesity, advanced disease severity, comorbidity and the consumption of a Western‐style diet were identified as the strongest risk factors for altered intestinal integrity. The risk of IP increases when coupled with a multiple disease state or combined with other environmental risk factors. Furthermore, many of the identified risk factors such as anthropometric measurements and biomarkers were external from intestinal health and rather resembled a metabolic‐like condition. Conclusions This review identified a number of potential risk factors for IP, ranging from biomarkers to anthropometric measurements, demographics, dietary intake and chronic diseases. These risk factors warrant the attention of clinicians and other healthcare providers to aid the identification of potential patients at risk of altered IP. Further research needs to examine whether the identified risk factors are homogeneous with the diagnosis of IP or whether the disease state influences the association.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Anthropometric Risk Factorsmentioning

confidence: 99%

Section: Biomarker Risk Factorsmentioning

confidence: 99%

Section: Biomarker Risk Factorsmentioning

confidence: 99%

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Risk factors associated with intestinal permeability in an adult population: A systematic review

et al. 2019

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Intestinal barrier integrity in anorexia nervosa (a pilot study)

Kleppe

Brønstad

Lied

et al. 2022

Intl J Eating Disorders

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Objective There is no conclusive evidence for involvement of intestinal barrier alteration in the etiology of anorexia nervosa (AN). The aims of this pilot study were to identify serum markers of intestinal barrier integrity in patients with AN and to determine the relationships between those markers and body mass index (BMI), eating disorder symptoms, gastrointestinal complaints, and liver synthesis function (international normalized ratio [INR]). Method Twenty‐five outpatients with AN prior to starting treatment and 28 healthy controls (HC) were assessed. BMI and serum markers of intestinal barrier integrity were measured, including zonulin family peptides (ZFP), lipopolysaccharide‐binding protein (LBP), and intestinal fatty‐acid‐binding protein (i‐FABP). Eating disorder symptoms and gastrointestinal complaints were evaluated via questionnaires. Results The serum ZFP concentration was significantly lower in patients with AN than in HC (44.2 [7.4] vs. 49.2 [5.6] ng/ml, mean [standard deviation], p = .008). LBP and i‐FABP did not differ between the two groups. In patients with AN, serum ZFP was significantly predicted by BMI (β = 0.479, p = .009), age (β = 0.411, p = .020), and INR (β = −0.388, p = .028). No such associations were found for either gastrointestinal complaints or eating disorder symptoms. Discussion Abnormal levels of serum ZFP were observed in patients with AN. Further studies with other assessment methods are warranted to examine intestinal barrier function in AN. Clinical Trial Registration http://clinicaltrials.gov Identifier: NCT02745067.

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Microbiota-Gut-Brain Axis and ED

Mack,

Seitz

2024

Eating Disorders

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Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women

Cited by 111 publications

References 60 publications

Risk factors associated with intestinal permeability in an adult population: A systematic review

Risk factors associated with intestinal permeability in an adult population: A systematic review

Intestinal barrier integrity in anorexia nervosa (a pilot study)

Microbiota-Gut-Brain Axis and ED

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