Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation
Marta Olivares,
Paula Hernandez-Calderon,
Sonia Cardenas-Brito
et al.
Abstract:BackgroundThe gut microbiota controls broad aspects of human metabolism and feeding behavior, but the basis for this control remains largely unclear. Given the key role of human dipeptidyl peptidase 4 (DPP4) in host metabolism, we investigated whether microbiota DPP4-like counterparts perform the same function.ResultsWe identified novel functional homologs of human DPP4 in several bacterial species inhabiting the human gut, and specific associations betweenParabacteroidesandPorphyromonasDPP4-like genes and typ… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.