2023
DOI: 10.1101/2023.12.18.572132
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Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation

Marta Olivares,
Paula Hernandez-Calderon,
Sonia Cardenas-Brito
et al.

Abstract: BackgroundThe gut microbiota controls broad aspects of human metabolism and feeding behavior, but the basis for this control remains largely unclear. Given the key role of human dipeptidyl peptidase 4 (DPP4) in host metabolism, we investigated whether microbiota DPP4-like counterparts perform the same function.ResultsWe identified novel functional homologs of human DPP4 in several bacterial species inhabiting the human gut, and specific associations betweenParabacteroidesandPorphyromonasDPP4-like genes and typ… Show more

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