Gut microbiota dysbiosis in patients with hepatitis B virus-related cirrhosis

Wu, Shu Ling; Chen, Shanjian; Lin, Jinxiu; Ou, Qishui

doi:10.1016/j.aohep.2022.100676

Cited by 20 publications

(17 citation statements)

References 12 publications

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“…Furthermore, metabolic changes at different stages of HBV infection were also observed by PICRUSt analysis. Consistent with another study[ 27 ], these results suggest that changes in the composition of the gut microbiota can significantly alter gene function, which may have a potential role in HBV-infected patients.…”

Section: Discussionsupporting

confidence: 91%

“…Nevertheless, one study has reported that the α-diversity is increased in cirrhosis patients compared to healthy controls and positively correlated to the Child-Pugh score[ 26 ]. In our study, a decreased ratio of Bacteroidetes to Firmicutes was observed as patients progressed from the IT phase to the IA phase, while another study has demonstrated that the ratio of Bacteroidetes to Firmicutes increased in patients with HBV-related cirrhosis compared to that of healthy individuals[ 27 ]. These results in different studies indicate that the results may vary greatly depending on the grouping.…”

Section: Discussionmentioning

confidence: 57%

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Gut microbiota of hepatitis B virus-infected patients in the immune-tolerant and immune-active phases and their implications in metabolite changes

Li¹,

Kang²,

Jiang³

et al. 2022

WJG

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BACKGROUND The microbes and metabolomics of microbiota dysbiosis in the gut in the different phases of hepatitis B virus (HBV) infection are not fully understood. AIM To investigate the specific gut microbiota and metabolites of the immune-tolerant (IT) and immune-active (IA) phases of chronic hepatitis B (CHB). METHODS Clinical fecal samples from healthy individuals and patients in the IT and IA phases of HBV infection were collected. Next, non-target metabolomics, bioinformatics, and 16S rDNA sequencing analyses were performed. RESULTS A total of 293 different metabolites in 14 phyla, 22 classes, 29 orders, 51 families, and 190 genera were identified. The four phyla of Firmicutes , Bacteroidetes , Actinobacteria , and Proteobacteria were the most abundant, accounting for 99.72%, 99.79%, and 99.55% in the healthy controls, IT-phase patients, and IA-phase patients, respectively. We further identified 16 genera with different richness in the IT phase and IA phase of HBV infection. Of the 134 named metabolites, 57 were upregulated and 77 were downregulated. A total of 101 different metabolic functions were predicted in this study, with 6 metabolic pathways having the highest enrichments, namely carbohydrate metabolism (14.85%), amino acid metabolism (12.87%), lipid metabolism (11.88%), metabolism of cofactors and vitamins (11.88%), xenobiotic biodegradation (9.9%), and metabolism of terpenoids and polyketides (7.92%). CONCLUSION These findings provide observational evidence of compositional alterations of the gut microbiome and some related metabolites in patients with IT-phase or IA-phase HBV infection. Further studies should investigate whether microbiota modulation can facilitate the progression of CHB and the cause-effect relationship between the gut microbiota and CHB.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 57%

Gut microbiota of hepatitis B virus-infected patients in the immune-tolerant and immune-active phases and their implications in metabolite changes

Li¹,

Kang²,

Jiang³

et al. 2022

WJG

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show abstract

“…Secondly, changes in the intestinal ora may contribute to this correlation. A study conducted in China found that the gut microbiota composition changed at different stages of hepatitis B-related cirrhosis, and gut microbiota shifts may contribute to cirrhosis progression [34]. Another study conducted in patients with kidney disease found that uremic toxins produced by gut microbiota can promote vascular calci cation [35].…”

Section: Discussionmentioning

confidence: 99%

Association Between Past Hepatitis B Infection and abdominal aorta calcification: National Health and Nutrition Examination Survey

Zhang

Cao

et al. 2023

Preprint

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Introduction: With mounting evidence, there is a postulation that Hepatitis B Infection may be a risk factor for atherosclerotic diseases. Abdominal aortic calcification (AAC) has been found to be significantly associated with subclinical atherosclerotic diseases. Our objective was to investigate the relationship between Hepatitis B core antibody and abdominal aortic calcification. Methods: In this cross-sectional observational study, data from the National Health and Nutrition Examination Survey (NHANES) conducted during 2013–2014 were utilized to investigate the relationship between Hepatitis B core antibody and AAC. The study used dual-energy X-ray absorptiometry to measure AAC and evaluated it using the Kauppila score system. The variable LBXHBC of the NHANES dataset was reviewed to identify patients with positive Hepatitis B core antibody. To assess the association between Hepatitis B core antibody and AAC, multivariate logistic regression mixed models and subgroup analyses were conducted. Results: The 2013–2014 data showed documentation of 288 patients with positive Hepatitis B core antibody. After adjusting for multiple variables, the multivariable odds ratios (95% CI) revealed that severe AAC was correlated with Hepatitis B infection (OR = 1.52, 95%CI [1 ~ 2.3]; p = 0.05), as opposed to the no Hepatitis B group. However, this association was not observed among individuals with mild AAC (OR = 1.22, 95%CI [0.9 ~ 1.65]; p = 0.205). Results were consistent in multiple subgroup and sensitivity analyses. Conclusions: Individuals who tested positive for Hepatitis B core antibody had a higher likelihood of severe AAC compared to those who tested negative, while no significant association was observed among individuals with mild AAC.

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“…At the same time, the proportion of beneficial bacteria including Bifidobacterium and Lactobacillus decreased, while the proportion of harmful bacteria such as Enterobacter increased in patients with liver cirrhosis through comparing patients with liver cirrhosis and normal population. And the abundance of intestinal harmful Streptococcus and Ruminococcus in patients with decompensated cirrhosis was higher than that in patients with compensated cirrhosis, meaning that the gut microbiota is severely damaged in patients with decompensated cirrhosis ( Shu et al, 2022 ). In fact, the body's immune-related cancers are closely linked to the gut microbiota ( Chen et al, 2021 , Gori et al, 2019 , Zhou et al, 2021 ).…”

Section: The Relationship Between Fermented Natural Products Gut Micr...mentioning

confidence: 99%

Fermented natural product targeting gut microbiota regulate immunity and anti-inflammatory activity: A possible way to prevent COVID-19 in daily diet

Cai

et al. 2022

Journal of Functional Foods

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Gut microbiota dysbiosis in patients with hepatitis B virus-related cirrhosis

Cited by 20 publications

References 12 publications

Gut microbiota of hepatitis B virus-infected patients in the immune-tolerant and immune-active phases and their implications in metabolite changes

Gut microbiota of hepatitis B virus-infected patients in the immune-tolerant and immune-active phases and their implications in metabolite changes

Association Between Past Hepatitis B Infection and abdominal aorta calcification: National Health and Nutrition Examination Survey

Fermented natural product targeting gut microbiota regulate immunity and anti-inflammatory activity: A possible way to prevent COVID-19 in daily diet

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