Gut microbiota: effect of pubertal status

Yuan, Xin; Chen, Ruimin; Zhang, Ying; Lin, Xiaoqin; Yang, Xiaohong

doi:10.1186/s12866-020-02021-0

Cited by 54 publications

(39 citation statements)

References 30 publications

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“…It is possible that obesity or, for example, a high-fat diet could alter microbiota progression during puberty. In contrast to our findings, a recent Chinese study showed a higher abundance of Clostridia in 5-year-olds compared with 15-year-olds 51 . In the 15-year-olds, several genera were found to be associated with the level of serum testosterone, but estradiol concentrations were not associated with microbiota composition 51 .…”

Section: Discussioncontrasting

confidence: 99%

Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Korpela

Kallio

Salonen

et al. 2021

Sci Rep

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Accumulating evidence indicates that gut microbiota may regulate sex-hormone levels in the host, with effects on reproductive health. Very little is known about the development of intestinal microbiota during puberty in humans. To assess the connection between pubertal timing and fecal microbiota, and to assess how fecal microbiota develop during puberty in comparison with adult microbiota, we utilized a Finnish allergy-prevention-trial cohort (Flora). Data collected at 13-year follow-up were compared with adult data from a different Finnish cohort. Among the 13-year-old participants we collected questionnaire information, growth data from school-health-system records and fecal samples from 148 participants. Reference adult fecal samples were received from the Health and Early Life Microbiota (HELMi) cohort (n = 840). Fecal microbiota were analyzed using 16S rRNA gene amplicon sequencing; the data were correlated with pubertal timing and compared with data on adult microbiota. Probiotic intervention in the allergy-prevention-trial cohort was considered as a confounding factor only. The main outcome was composition of the microbiota in relation to pubertal timing (time to/from peak growth velocity) in both sexes separately, and similarity to adult microbiota. In girls, fecal microbiota became more adult-like with pubertal progression (p = 0.009). No such development was observed in boys (p = 0.9). Both sexes showed a trend towards increasing relative abundance of estrogen-metabolizing Clostridia and decreasing Bacteroidia with pubertal development, but this was statistically significant in girls only (p = 0.03). In girls, pubertal timing was associated positively with exposure to cephalosporins prior to the age of 10. Our data support the hypothesis that gut microbiota, particularly members of Ruminococcaceae, may affect pubertal timing, possibly via regulating host sex-hormone levels.Trial registration The registration number for the allergy-prevention-trial cohort: ClinicalTrials.gov, NCT00298337, registered 1 March 2006—Retrospectively registered, https://clinicaltrials.gov/show/NCT00298337. The adult-comparison cohort (HELMi) is NCT03996304.

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Section: Discussioncontrasting

confidence: 99%

Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Korpela

Kallio

Salonen

et al. 2021

Sci Rep

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“…Eggerthellaceae , which has been linked to positive effects in lipid metabolism, was also inversely correlated with body weight gain in mice [ 60 ]. Although relatively little is known about the genera Adlercreutzia , it has been shown in pubertal human subjects to be positively associated with testosterone [ 61 ]. Adlercreutzia have also been shown to metabolize phytoestrogens [ 62 ] and it is therefore possible that this bacteria could be affected by sex hormones, although this warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Paternal Methyl Donor Supplementation in Rats Improves Fertility, Physiological Outcomes, Gut Microbial Signatures and Epigenetic Markers Altered by High Fat/High Sucrose Diet

Chleilat

Schick

Deleemans

et al. 2021

IJMS

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Increased consumption of high fat/sucrose (HF/S) diets has contributed to rising rates of obesity and its co-morbidities globally, while also negatively impacting male reproductive health. Our objective was to examine whether adding a methyl donor cocktail to paternal HF/S diet (HF/S+M) improves health status in fathers and offspring. From 3–12 weeks of age, male Sprague Dawley rats consumed a HF/S or HF/S+M diet. Offspring were followed until 16 weeks of age. Body composition, metabolic markers, gut microbiota, DNA methyltransferase (DNMT) and microRNA expression were measured in fathers and offspring. Compared to HF/S, paternal HF/S+M diet reduced fat mass in offspring (p < 0.005). HF/S+M fathers consumed 16% fewer kcal/day, which persisted in HF/S+M female offspring and was explained in part by changes in serum glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY) levels. Compared to HF/S, HF/S+M fathers had a 33% improvement in days until conception and 300% fewer stillbirths. In fathers, adipose tissue DNMT3a and hepatic miR-34a expression were reduced with HF/S+M. Adult male offspring showed upregulated miR-24, -33, -122a and -143 expression while females exhibited downregulated miR-33 expression. Fathers and offspring presented differences in gut microbial signatures. Supplementing a paternal HF/S diet with methyl-donors improved fertility, physiological outcomes, epigenetic and gut microbial signatures intergenerationally.

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“…It can be inferred that the abundance of Allobaculum is negatively correlated with intestinal permeability. All microorganisms of the genus Coprococcus can promote the production of short-chain fatty acids, which is good for the health of the host [ 48 ]. Kelly et al also found that a low abundance of Coprococcus can promote the development of IBD, which is also consistent with the results of this experiment [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice

Chen

Tian

et al. 2021

Molecules

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Inflammatory bowel disease (IBD), which significantly affects human health, has two primary presentations: Crohn’s disease and ulcerative colitis (UC). Highland barley is the most common food crop for Tibetans and contains much more β-glucan than any other crop. Highland barley β-glucan (HBBG) can relieve the gastrointestinal dysfunction and promote intestines health. This study aimed to evaluate whether HBBG can relieve UC in mice. A mouse model of UC was established by adding 2% dextran sulfate sodium (DSS) to drinking water for 1 week. UC was alleviated after the introduction of the HBBG diet, as indicated by reductions in the disease activity index (DAI) score, histopathological damage, and the concentration of colonic myeloperoxidase (MPO), along with an improvement in colonic atrophy. Furthermore, we found that HBBG can increase the relative transcriptional levels of genes encoding ZO-1, claudin-1, occludin, and mucin2 (MUC2), thereby reducing intestinal permeability. Additionally, HBBG maintained the balance of proinflammatory and anti-inflammatory cytokines and modulated the structure of the intestinal flora.

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Gut microbiota: effect of pubertal status

Cited by 54 publications

References 30 publications

Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Paternal Methyl Donor Supplementation in Rats Improves Fertility, Physiological Outcomes, Gut Microbial Signatures and Epigenetic Markers Altered by High Fat/High Sucrose Diet

β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice

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