Gut microbiota, endotoxemia, inflammation, and oxidative stress in patients with heart failure, left ventricular assist device, and transplant

Yuzefpolskaya, M.; Bohn, Bruno; Nasiri, Mojdeh; Zuver, A.M.; Onat, Duygu; Royzman, E.A.; Nwokocha, J.; Mabasa, M.; Pinsino, A.; Brunjes, Danielle L.; Gaudig, A.; Clemons, Autumn; Trinh, Pauline; Stump, Stephania; Giddins, Marla J.; Topkara, V.K.; Garan, A.R.; Takeda, Koji; Takayama, Hiroo; Naka, Yoshifumi; Farr, Maryjane; Nandakumar, Renu; Uhlemann, Anne Catrin; Colombo, P.C.; Demmer, Ryan T.

doi:10.1016/j.healun.2020.02.004

Cited by 85 publications

(83 citation statements)

References 47 publications

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“…Importantly, the variation in species richness differed among the treated groups, wherein those exposed to only one of the relevant conditions displayed diminished species richness. Our findings concur with previous studies that showed an alteration in the microbiome in both HF and SF conditions and a decreased alpha diversity in HF patients (Luedde et al, 2017), (Yuzefpolskaya et al, 2020).…”

Section: Discussionsupporting

confidence: 93%

Impact of sleep fragmentation, heart failure, and their combination, on the gut microbiome

Khannous-Lleiffe

Willis

Saus

et al. 2020

Preprint

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Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of the cardiac ventricular filling and/or ejection of blood capacity. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, male mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting that some of the individual effects of either HF or SF cancel each other out when applied concomitantly.IMPORTANCEThe study demonstrates the potential of the gut microbiome as a source of molecular markers for the diagnosis, prevention, and treatment of both heart failure and sleep fragmentation conditions in isolation. Our results provide the first evidence of an antagonistic effect of the presence of both conditions in the gut microbiome dysbiosis, showing an attenuation of the alterations that are observed when considering them separately.

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Section: Discussionsupporting

confidence: 93%

Impact of sleep fragmentation, heart failure, and their combination, on the gut microbiome

Khannous-Lleiffe

Willis

Saus

et al. 2020

Preprint

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“…This result indicates that the restoration of hemodynamics is only partially responsible for improving the overall state of HF and attention to the new type of intestinal dysfunction-inflammation partnership is necessary. 81,82…”

Section: Tmao As a Prognostic Marker Of Hfmentioning

confidence: 99%

TMAO: how gut microbiota contributes to heart failure

Zhang

Wang

et al. 2021

Translational Research

169

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An increasing amount of evidence reveals that the gut microbiota is involved in the pathogenesis and progression of various cardiovascular diseases. In patients with heart failure (HF), splanchnic hypoperfusion causes ischemia and intestinal edema, allowing bacterial translocation and bacterial metabolites to enter the blood circulation via an impaired intestinal barrier. This results in local and systemic inflammatory responses. Gut microbe-derived metabolites are implicated in the pathology of multiple diseases, including HF. These landmark findings suggest that gut microbiota influences the host's metabolic health, either directly or indirectly by producing several metabolites. In this review, we mainly discuss a newly identified gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which appears to participate in the pathologic processes of HF and can serve as an early warning marker to identify individuals who are at the risk of disease progression. We also discuss the potential of the gutÀTMAOÀHF axis as a new target for HF treatment and highlight the current controversies and potentially new and exciting directions for future research.

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“…The different results might be clari ed by diverse dosages of probiotics supplementations and different clinical setting of individuals, who took part in those studies. Microbial translocation has been proposed to be a driver of in ammation and immune activation in CAD patients [5,29].…”

Section: Discussionmentioning

confidence: 99%

Effect of Probiotic Supplementation Along With Calorie Restriction on Metabolic Endotoxemia, and Mega Inflammation in Coronary Artery Disease Patients: A Double Blind Placebo Controlled Randomized Clinical Trial

Moludi

Kafil

Gholizadeh

et al. 2020

Preprint

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Purpose: Dysbiosis has been associated with increased microbial translocation, leading to chronic inflammation in cardiovascular diseases (CVD). It has been proposed that modulation of gut microbiota by probiotic might modify metabolic endotoxemia. Therefore, the purpose of this study was to examine the effects of Lactobacillus rhamnosus GG (LGG) on metabolic endotoxemia, and marker of inflammation in CVD subjects. Methods: This study was a 12-weeks randomized, double-blind, and intervention on 44 patients with CVD. Patients were randomly allocated to receive either one LGG capsule 1.6 ×109 colony-forming unit (CFU) or the placebo capsules for 12 weeks. Serum levels of interleukin-1β (IL-1β), Toll-like receptor 4 (TLR4), interleukin-10 (IL-10), and lipopolysaccharide (LPS), were assessed before and after the intervention. Results: A significant decrease in IL1-Beta concentration (-1.88 ± 2.25, vs. 0.56 ± 1.58 mmol/L, P=0.027), and LPS levels (-5.20 ±2.70 vs. 2.96+ 5.27 mg/L, P=0.016), was observed after the probiotic supplementation compared with the placebo. Subjects who had ≥2.5 kg weight loss showed signiﬁcantly improved in some variables, compared to patients with <2.5 kg weight reduction, regardless of the supplement they receive.Conclusion: These data provide preliminary evidence that probiotic supplementation has beneficial effects on metabolic endotoxemia, and mega inflammation in subjects with CVD.

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Gut microbiota, endotoxemia, inflammation, and oxidative stress in patients with heart failure, left ventricular assist device, and transplant

Cited by 85 publications

References 47 publications

Impact of sleep fragmentation, heart failure, and their combination, on the gut microbiome

Impact of sleep fragmentation, heart failure, and their combination, on the gut microbiome

TMAO: how gut microbiota contributes to heart failure

Effect of Probiotic Supplementation Along With Calorie Restriction on Metabolic Endotoxemia, and Mega Inflammation in Coronary Artery Disease Patients: A Double Blind Placebo Controlled Randomized Clinical Trial

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