Gut Microbiota Features in Young Children With Autism Spectrum Disorders

Coretti, Lorena; Paparo, Lorella; Riccio, Maria Pia; Amato, Felice; Cuomo, Mariella; Natale, Alessandro; Borrelli, Luca; Corrado, Giusi; De, Carmen; Comegna, Marika; Buommino, Elisabetta; Castaldo, Giuseppe; Bravaccio, Carmela; Chiariotti, Lorenzo; Canani, Roberto Berni; Lembo, Francesca

doi:10.3389/fmicb.2018.03146

Cited by 185 publications

(229 citation statements)

References 70 publications

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“…However, according to Coretti et al . () and Zhang et al . (), the Bacteroidetes/Firmicutes ratio in Italian and Chinese children with ASD, respectively, was higher than their HC groups.…”

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 90%

“…No functional gastrointestinal disorders (FGID) were reported in five articles (De Angelis et al ., ; Inoue et al ., ; Shaaban et al ., ; Berding and Donovan, ; Coretti et al ., ). Although there is a greater prevalence of GI symptoms in ASD (McElhanon et al ., ; Martínez‐González and Andreo‐Martínez, ) there are studies reporting no FGID, as some authors excluded children with ASD and FGID in their studies (De Angelis et al ., ; Strati et al ., ; Berding and Donovan, ).…”

Section: Sample Characteristics and Other Parameters Studiedmentioning

confidence: 97%

“…Phylogenetic map of bacterial populations (Phyla, families, genera and species level) in ASD. Note: [A = Williams et al ., ; B = Gondalia et al ., ; C = Kang et al ., ; D = Wang et al ., ; E = De Angelis et al ., ; F = Son et al ., ; G = Tomova et al ., ; H = Inoue et al ., ; I = Strati et al ., ; J = Iovene et al ., ; K= Luna et al ., ; L = Finegold et al ., ; M = Kushak et al ., ; N = Shaaban et al ., ; O = Gora et al ., ; P = Kang et al ., ; Q = Pulikkan et al ., ; R = Rose et al ., ; S = Coretti et al ., ; T = Zhang et al ., ; U = Berding and Donovan, ]. …”

Section: Dysbiosis Of the Gm In Asdmentioning

confidence: 99%

“…At family level: Lactobacillaceae, Enterococcaceae, Erysipelotrichaceae and Desulfovibrionaceae (Pulikkan et al ., ), Peptostreptococcaceae (Berding and Donovan, ), Bacteroidaceae, Lachnospiraceae and Ruminococcaceae (Rose et al ., ), and presumptive Enterobacteriaceae (De Angelis et al ., ) were found to have statistically significant higher abundance in children with ASD compared to their control groups. At genus level: Porphyromonas , presumptive Bacteroides , Porphyromonas and Prevotella , Caloromator , Sarcina , Anaerofilum , presumptive Pseudomonas and Aeromonas , and Shigella (De Angelis et al ., ), Ruminococcus and Lachnospira (Coretti et al ., ), Collinsella (Strati et al ., ), Mitsuokella and Megasphaera (Pulikkan et al ., ), Burkholderia (Kushak et al ., ), Roseburia (De Angelis et al ., ; Berding and Donovan, ; Coretti et al ., ), Peptostreptococcus and Ralstonia (Kushak et al ., ), and Candida (Iovene et al ., ; Strati et al ., ) were found to have statistically significant higher abundance in children with ASD compared to their control groups. At species level: Bilophila wadsworthia , Flavonifractor plautii , Roseburia intestinalis , Lachnoclostridium boltae , Lachnoclostridium hathewayi , Oscillospira valericigenes , Clostridium lituseburense and Clostridium aldenense (Luna et al ., ), Ruminococcus gnavus and Ruminococcus torques (Wang et al ., ), Lactobacillus ruminis (Pulikkan et al ., ) and Akkermansia muciniphila (De Angelis et al ., ) were found to have statistically significant higher abundance in children with ASD compared to their control groups.…”

Section: Dysbiosis Of the Gm In Asdmentioning

confidence: 99%

“…Specifically, children with ASD eating 20 foods or less in their diet had lower intakes of pectin, vitamin C, niacin, vitamin B6, folate and selenium but higher intakes of added sugars (Berding and Donovan, ). Streptococcus was found to be less abundant in duodenal biopsy samples from the second part of the duodenum of American children with ASD compared to their HC group (Kushak et al ., ), in faeces of Chinese (Zhang et al ., ) and Japanese (Inoue et al ., ) children with ASD compared to their HC groups, respectively, and in faeces of Italian children with ASD compared to their HC (Coretti et al ., ) and siblings (De Angelis et al ., ) groups, respectively, with Streptococcus and Enterococcus being the dominant genera of the Bacilli class in the work of De Angelis et al . ().…”

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 99%

See 4 more Smart Citations

An approach to gut microbiota profile in children with autism spectrum disorder

Andreo-Martínez

García-Martínez

Sánchez-Samper

et al. 2019

Environ Microbiol Rep

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Summary In recent years, there has been an increase in studies on the implications of gut microbiota (GM) on the behaviour of children with autism spectrum disorders (ASD) due to a dysbiosis in GM that can trigger onset, development or progression of ASD through the microbiota–gut–brain axis. The aim of this study is to carry out a systematic review of articles from the last 6 years that analyse GM in children with ASD compared to GM in control groups. Children with ASD showed a higher abundance of Roseburia and Candida genera, and lower abundance of Dialister, Bilophila, Veillonella, Streptococcus, Coprococcus and Prevotella genera. Those differences can be attributed to factors such as different nationalities, nature of control groups, place where the sample was taken, gastrointestinal (GI) problems or bacterial detection methods. It is still too early to define a specific GM profile of children with ASD, and future studies should focus on homogenizing the characteristics of samples and control groups. Furthermore, new multicentre studies should also focus on the impact of GM on GI physiology, neurophysiology and behaviour of children with ASD, and on performing psychometric analyses of the correlation between the severity of ASD behavioural symptoms and GM profiles.

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“…However, according to Coretti et al . () and Zhang et al . (), the Bacteroidetes/Firmicutes ratio in Italian and Chinese children with ASD, respectively, was higher than their HC groups.…”

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 90%

Section: Sample Characteristics and Other Parameters Studiedmentioning

confidence: 97%

Section: Dysbiosis Of the Gm In Asdmentioning

confidence: 99%

Section: Dysbiosis Of the Gm In Asdmentioning

confidence: 99%

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 99%

See 3 more Smart Citations

An approach to gut microbiota profile in children with autism spectrum disorder

Andreo-Martínez

García-Martínez

Sánchez-Samper

et al. 2019

Environ Microbiol Rep

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Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Xie

et al. 2022

Autism Research

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Autism spectrum disorder (ASD) is associated with altered gut microbiota. However, there has been little consensus on the altered bacterial species and studies have had small sample sizes. We aimed to identify the taxonomic composition and evaluate the changes in the fecal microbiota in Chinese children with ASD by using a relatively large sample size. We conducted a case–control study of 101 children with ASD and 103 healthy controls in China. Demographic information and fecal samples were collected, and the V3‐V4 hypervariable regions of the bacterial 16S ribosomal RNA (rRNA) gene were sequenced. The alpha and beta diversities between the two groups were significantly different. After correcting for multiple comparisons, at the phylum level the relative abundances of Actinobacteria and Proteobacteria in the case group were significantly higher than those in the control group. The relative abundance of the Escherichia‐Shigella genus in the case group was significantly higher than that of the control group, and the relative abundance of Blautia and unclassified_f__Lachnospiraceae in the control group were higher than that of the case group. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States analysis showed that children with ASD may have disturbed functional pathways, such as amino acid metabolism, cofactor and vitamin metabolism, and the AMP‐activated protein kinase signaling pathway. This study revealed the characteristics of the intestinal flora of Chinese children with ASD and provided further evidence of gut microbial dysbiosis in ASD. Lay Summary This study characterized the gut microbiota composition of 101 children with ASD and 103 healthy controls in China. The altered gut microbiota may contribute significantly to the risk of ASD, including significant increases in the relative abundances of Actinobacteria, Proteobacteria and Escherichia‐Shigella and significant decrease of Blautia and unclassified_f__Lachnospiraceae. This study provided further evidence of gut microbial dysbiosis in ASD.

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Dysregulation of synaptic pruning as a possible link between intestinal microbiota dysbiosis and neuropsychiatric disorders

Eltokhi

Janmaat

Genedi

et al. 2020

J of Neuroscience Research

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The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (microbiota-gut-brain axis). The microbial composition has important influences on general health and the development of several organ systems, such as the gastrointestinal tract, the immune system, and also the brain. Clinical studies have shown that microbiota alterations are associated with a wide range of neuropsychiatric disorders including autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia, and bipolar disorder. In this review, we dissect the link between these neuropsychiatric disorders and the intestinal microbiota by focusing on their effect on synaptic pruning, a vital process in the maturation and establishing efficient functioning of the brain. We discuss in detail how synaptic pruning is dysregulated differently in the aforementioned neuropsychiatric disorders and how it can be influenced by dysbiosis and/or changes in the intestinal microbiota composition. We also review that the improvement in the intestinal microbiota composition by a change in diet, probiotics, prebiotics, or fecal microbiota transplantation may play a role in improving neuropsychiatric functioning, which can be at least partly explained via the optimization of synaptic pruning and neuronal connections. Altogether, the demonstration of the microbiota's influence on brain function via microglial-induced synaptic pruning addresses the possibility that the manipulation of microbiota-immune crosstalk represents a promising strategy for treating neuropsychiatric disorders.

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Gut Microbiota Features in Young Children With Autism Spectrum Disorders

Cited by 185 publications

References 70 publications

An approach to gut microbiota profile in children with autism spectrum disorder

An approach to gut microbiota profile in children with autism spectrum disorder

Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Dysregulation of synaptic pruning as a possible link between intestinal microbiota dysbiosis and neuropsychiatric disorders

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