Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model

Mauras, Aurélie; Wopereis, Harm; Yeop, Intan; Esber, Nathalie; Delannoy, Johanne; Labellie, Chantal; Reygner, Julie; Kapel, Nathalie; Slump, R. A.; Eijndthoven, Tiemen van; Rutten, Lieke; Knol, Jan; Garssen, Johan; Harthoorn, Lucien F.; Mj, Butel; Bajaj‐Elliott, Mona; Hartog, Anita; Waligora‐Dupriet, Anne‐Judith

doi:10.1111/all.13787

Cited by 25 publications

(39 citation statements)

References 10 publications

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“…Numerous clinical and epidemiological studies have shown that the clinical manifestations and development of allergies are related to abnormal intestinal microbiota. 46 To our surprise, the diversity of intestinal microbiota in the allergic mice was higher than that in the control group, contrary to reasoning based on other enteritis diseases. However, most allergy-related intestinal microbiota showed that the diversity of intestinal microbiota increased, indicating that the diversity of intestinal microbiota was not always positively correlated with individual health.…”

Section: Discussioncontrasting

confidence: 73%

Cow's milk α_S1-casein is more sensitizing than goat's milk α_S1-casein in a mouse model

Zhang

Zhou

et al. 2022

Food Funct.

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Section: Discussioncontrasting

confidence: 73%

Cow's milk α_S1-casein is more sensitizing than goat's milk α_S1-casein in a mouse model

Zhang

Zhou

et al. 2022

Food Funct.

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“…70 In another study, microbiota from infants with a low bifidobacteria/Lachnospiraceae ratio orients the murine immune system toward a Th2 atopic profile with clinical symptoms of allergy. 71 Bifidobacterium breve is a species commonly isolated from the intestines of healthy breastfed infants and from human milk and is thought to have a significant impact on the development of immune tolerance. 72 In a longitudinal study of a Canadian child cohort, it was found that infants at risk of asthma showed gut microbial changes during the first 100 days of life.…”

Section: Microbiomementioning

confidence: 99%

Advances and novel developments in environmental influences on the development of atopic diseases

Alkotob

Cannedy

Harter

et al. 2020

Allergy

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Both genes and the environment shape human health and disease. Although IgE-mediated allergic diseases (atopic diseases) have a genetic component and are more prevalent in individuals with a family history of allergic disease, the observed rapid increases in allergic diseases suggest that environmental factors are the predominant driving forces behind these increases rather than genetic alterations. 1,2 Common atopic diseases include atopic dermatitis, food allergy, allergic rhinitis, and allergic asthma. Human diets and lifestyle have undergone major alterations. The exposome, which is the sum total of all the exposures of an individual in a lifetime, has undergone major shifts in the last few decades, affecting human health and disease. A number of environmental factors have been implicated in the increased prevalence of allergic diseases. Predominant among them are increased exposure to pollutants and decreased exposure to microbes and parasitic infections. Air pollution has increased significantly in the last few decades. The hygiene hypothesis suggests that increased hygiene and lack of exposure to microbes and parasitic infections at an early age prevents the necessary stimulus to train the immune system to develop tolerogenic responses. Lifestyle factors,

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“…Several birth cohort studies have shown an altered gut microbiota in infants with CMA versus healthy infants (6)(7)(8). Moreover, we and others have shown the protective role of a healthy microbiota and the deleterious role of a CMA-associated microbiota in humanized ␤-lactoglobulin (BLG)-sensitized mouse models (9,10). Intestinal commensal bacteria and their sequential establishment are known to play a crucial role in the maturation of the intestinal immune system, modulation of the T-helper (Th) balance, acquisition of oral tolerance, and maintenance of gut wall epithelial integrity.…”

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confidence: 75%

Three Candidate Probiotic Strains Impact Gut Microbiota and Induce Anergy in Mice with Cow's Milk Allergy

Esber

Mauras

Delannoy

et al. 2020

Appl Environ Microbiol

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Cow's milk allergy is a worldwide public health issue, especially since there is no effective treatment, apart from milk and dairy product avoidance. The aim of this study was to assess the beneficial role of three probiotic strains previously selected for their prophylactic properties in a mouse model of β-lactoglobulin allergy. Administration of Lactobacillus rhamnosus LA305, L. salivarius LA307, or Bifidobacterium longum subsp. infantis LA308, for 3 weeks post-sensitization and challenge modified the composition of the gut microbiota with an increase in Prevotella NK3B31 and a decrease in Marvinbryantia, belonging to the Lachnospiraceae group. Although no impact on markers of sensitization was detected, modifications of foxp3, tgfβ and il10 ileal gene expression as well as plasma metobolomic alteration in the tryptophan pathway were observed. Moreover, ex-vivo studies showed that all probiotic strains induced a significant decrease in cytokine production by β-lactoglobulin-stimulated splenocytes. Altogether, these results suggest that the three probiotic strains tested lead to alterations in immune responses i.e. induction of a tolerogenic anergy and anti-inflammatory responses. This anergy could be linked to cecal microbiota modifications although no impact on fecal SCFA concentration was detected. Anergy could also be linked to a direct impact of probiotic strains on dendritic cells as co-stimulatory molecule expression was decreased following their co-incubation with BMDCs. To conclude, all three candidate probiotic strains induced strain-specific gut microbiota and metabolic changes, which could potentially be beneficial for general health, as well as anergy that could contribute to oral tolerance acquisition. IMPORTANCE We previously showed that three probiotic strains i.e. Lactobacillus rhamnosus LA305, L. salivarius LA307, and Bifidobacterium longum subsp. infantis LA308 exerted different preventive effects in a mouse model of cow's milk allergy. In this study, we evaluated their potential benefits in a curative mouse model of cow's milk allergy. When administered for 3-weeks after the sensitization process and a first allergic reaction, none of the strains modified the levels of sensitization and allergic markers. However, all three strains affected gut bacteria communities and modified immune and inflammatory responses leading to a tolerogenic profile. Interestingly, all three strains exerted a direct effect on dendritic cells which are known to play a major role in food sensitization through their potentially tolerogenic properties and anergic responses. Altogether, these data indicate a potentially beneficial role of the probiotic strains tested in this model of cow's milk allergy with regard to tolerance acquisition.

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Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model

Cited by 25 publications

References 10 publications

Cow's milk α_S1-casein is more sensitizing than goat's milk α_S1-casein in a mouse model

Cow's milk α_S1-casein is more sensitizing than goat's milk α_S1-casein in a mouse model

Advances and novel developments in environmental influences on the development of atopic diseases

Three Candidate Probiotic Strains Impact Gut Microbiota and Induce Anergy in Mice with Cow's Milk Allergy

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Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model

Cited by 25 publications

References 10 publications

Cow's milk αS1-casein is more sensitizing than goat's milk αS1-casein in a mouse model

Cow's milk αS1-casein is more sensitizing than goat's milk αS1-casein in a mouse model

Advances and novel developments in environmental influences on the development of atopic diseases

Three Candidate Probiotic Strains Impact Gut Microbiota and Induce Anergy in Mice with Cow's Milk Allergy

Contact Info

Product

Resources

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Cow's milk α_S1-casein is more sensitizing than goat's milk α_S1-casein in a mouse model

Cow's milk α_S1-casein is more sensitizing than goat's milk α_S1-casein in a mouse model