Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions

Ashonibare, Victory J.; Akorede, Bolaji A.; Ashonibare, Precious J.; Akhigbe, Tunmise M.; Akhigbe, Roland Eghoghosoa

doi:10.3389/fimmu.2024.1346035

Cited by 13 publications

(2 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, the inoculation of certain strains of Lactobacilli in female mice led to changes in serum levels of estrogen and testosterone [165]. The relationship between testosterone and gut microbiota is intricate; testosterone alters the composition of gut microbiota, and, at the same time, gut microbiota also influences the production of testosterone [166]. Marlke et al demonstrated that, after microbiota transplantation, there was an increase in circulating testosterone levels.…”

Section: Brain-gut Microbiota Axis and Sex Differencesmentioning

confidence: 99%

Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation

Caldarelli,

Rio,

Marrone

et al. 2024

IJMS

View full text Add to dashboard Cite

In recent years, there has been a growing interest in the concept of the “gut–brain axis”. In addition to well-studied diseases associated with an imbalance in gut microbiota, such as cancer, chronic inflammation, and cardiovascular diseases, research is now exploring the potential role of gut microbial dysbiosis in the onset and development of brain-related diseases. When the function of the intestinal barrier is altered by dysbiosis, the aberrant immune system response interacts with the nervous system, leading to a state of “neuroinflammation”. The gut microbiota–brain axis is mediated by inflammatory and immunological mechanisms, neurotransmitters, and neuroendocrine pathways. This narrative review aims to illustrate the molecular basis of neuroinflammation and elaborate on the concept of the gut–brain axis by virtue of analyzing the various metabolites produced by the gut microbiome and how they might impact the nervous system. Additionally, the current review will highlight how sex influences these molecular mechanisms. In fact, sex hormones impact the brain–gut microbiota axis at different levels, such as the central nervous system, the enteric nervous one, and enteroendocrine cells. A deeper understanding of the gut–brain axis in human health and disease is crucial to guide diagnoses, treatments, and preventive interventions.

show abstract

Section: Brain-gut Microbiota Axis and Sex Differencesmentioning

confidence: 99%

Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation

Caldarelli,

Rio,

Marrone

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Metagenomic investigation of the chicken reproductive microbiome has arisen as a new area of study, providing insight into the relationships between host genetics, microbiota composition, and reproductive health. We can investigate the role of the microbiome in regulating fertility, disease resistance, and immunological responses in chickens by identifying the microbial populations in the reproductive tract [ 18 ]. Metagenomics has implications for developing techniques to modify the microbiome for better reproductive health [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Omics Revolution in Understanding Chicken Reproduction: A Comprehensive Review

Wadood,

Zhang

2024

CIMB

View full text Add to dashboard Cite

Omics approaches have significantly contributed to our understanding of several aspects of chicken reproduction. This review paper gives an overview of the use of omics technologies such as genomics, transcriptomics, proteomics, and metabolomics to elucidate the mechanisms of chicken reproduction. Genomics has transformed the study of chicken reproduction by allowing the examination of the full genetic makeup of chickens, resulting in the discovery of genes associated with reproductive features and disorders. Transcriptomics has provided insights into the gene expression patterns and regulatory mechanisms involved in reproductive processes, allowing for a better knowledge of developmental stages and hormone regulation. Furthermore, proteomics has made it easier to identify and quantify the proteins involved in reproductive physiology to better understand the molecular mechanisms driving fertility, embryonic development, and egg quality. Metabolomics has emerged as a useful technique for understanding the metabolic pathways and biomarkers linked to reproductive performance, providing vital insights for enhancing breeding tactics and reproductive health. The integration of omics data has resulted in the identification of critical molecular pathways and biomarkers linked with chicken reproductive features, providing the opportunity for targeted genetic selection and improved reproductive management approaches. Furthermore, omics technologies have helped to create biomarkers for fertility and embryonic viability, providing the poultry sector with tools for effective breeding and reproductive health management. Finally, omics technologies have greatly improved our understanding of chicken reproduction by revealing the molecular complexities that underpin reproductive processes.

show abstract