Gut microbiota, immunity and pain

Santoni, Matteo; Miccini, Francesca; Battelli, Nicola

doi:10.1016/j.imlet.2020.11.010

Cited by 35 publications

(28 citation statements)

References 42 publications

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“…depression and anxiety), 24 , 32 , 33 Parkinson’s disease, 34 increased hypothalamic pituitary adrenal axis (HPA) activity, 35 systemic lupus erythematosus 36 and systemic inflammation. 37 , 38 And, there is a growing appreciation that the gut microbiome may contribute to chronic extra-abdominal pain states, 1 , 3 – 6 for example in cutaneous inflammatory hyperalgesia 39 and paclitaxel-induced cutaneous thermal and mechanical nociception. 11 However, to the best of our knowledge evaluation of the role of the gut microbiome on skeletal muscle mechanical hyperalgesia has not previously been evaluated.…”

Section: Discussionmentioning

confidence: 99%

A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat

2021

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Adult rats that experienced neonatal limited bedding (NLB), a form of early-life stress, experience persistent muscle mechanical hyperalgesia. Since there is a growing recognition that the gut microbiome regulates pain and nociception, and that early-life stress produces a long-lasting impact on the gut microbiome, we tested the hypothesis that persistent muscle hyperalgesia seen in adult NLB rats could be ameliorated by interventions that modify the gut microbiome. Adult NLB rats received probiotics, either Lactobacillus rhamnosus GG (10 billion CFU/150 ml) or De Simone Formulation (DSF) (112.5 billion CFU/150 ml mixture of 8 bacterial species), in their drinking water, or non-absorbable antibiotics, rifaximin or neomycin, admixed with cookie dough, to provide 50 mg/kg. Mechanical nociceptive threshold in the gastrocnemius muscle was evaluated before and at several time points after administration of probiotics or antibiotics. Adult NLB rats fed probiotics L. Rhamnosus or DSF, antibiotics, as well as rats fed non-absorbable antibiotics rifaximin or neomycin, had markedly attenuated muscle mechanical hyperalgesia. We hypothesize that persistent skeletal muscle hyperalgesia produced by NLB stress may be, at least in part, due to a contribution of the gut microbiome, and that modulation of gut microbiome using probiotics or non-absorbable antibiotics, may be novel therapeutic approaches for the treatment of chronic musculoskeletal pain.

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Section: Discussionmentioning

confidence: 99%

A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat

2021

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“…An increasing body of research demonstrates the critical function of gut microbiota in acute and chronic pain (neuropathic, inflammatory, and viscera) modulation and has ushered into a new era in pain management [91,92]. Additionally, gut microbiota-derived mediators in the central nervous system may modulate induction and maintenance of central sensitization via regulating neuroinflammation, which involves the activation of blood-brain barrier cells, microglia, and infiltrating immune cells [91,93,94].…”

Section: Impact Of Diet and Nutrition On Pain In Cancer Survivors Through Gut Microbiotamentioning

confidence: 99%

Diet/Nutrition: Ready to Transition from a Cancer Recurrence/Prevention Strategy to a Chronic Pain Management Modality for Cancer Survivors?

Yılmaz

Malfliet

Elma

et al. 2022

JCM

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Evidence for the relationship between chronic pain and nutrition is mounting, and chronic pain following cancer is gaining recognition as a significant area for improving health care in the cancer survivorship population. This review explains why nutrition should be considered to be an important component in chronic pain management in cancer survivors by exploring relevant evidence from the literature and how to translate this knowledge into clinical practice. This review was built on relevant evidence from both human and pre-clinical studies identified in PubMed, Web of Science and Embase databases. Given the relationship between chronic pain, inflammation, and metabolism found in the literature, it is advised to look for a strategic dietary intervention in cancer survivors. Dietary interventions may result in weight loss, a healthy body weight, good diet quality, systemic inflammation, and immune system regulations, and a healthy gut microbiota environment, all of which may alter the pain-related pathways and mechanisms. In addition to being a cancer recurrence or prevention strategy, nutrition may become a chronic pain management modality for cancer survivors. Although additional research is needed before implementing nutrition as an evidence-based management modality for chronic pain in cancer survivors, it is already critical to counsel and inform this patient population about the importance of a healthy diet based on the data available so far.

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“…Gut microbiota can release nervous system factors involved in the regulation of gut brain-axis communication, such as 5-HT released by genera Candida , Streptococcus , Escherichia and Enterococcus , dopamine or norepinephrine produced by genera Escherichia , Bacillus and Saccharomyces , acetylcholine generated by genus Lactobacillus , γ-aminobutyric acid produced by genera Lactobacillus and Bifidobacterium ( Holzer and Farzi, 2014 ). Moreover, gut microbiota-derived mediators can activate Toll-like receptors (TLRs), GABA receptors, and transient receptor potentials (TRP), and so on, participating in the regulation of chronic pain ( Santoni et al., 2021 ).…”

Section: Gut Microbiota Medium or Metabolites And Hyperalgesiamentioning

confidence: 99%

Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?

Chen

Zhan

et al. 2021

Front. Cell. Infect. Microbiol.

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In recent years, increasing studies have been conducted on the mechanism of gut microbiota in neuropsychiatric diseases and non-neuropsychiatric diseases. The academic community has also recognized the existence of the microbiota-gut-brain axis. Chronic pain has always been an urgent difficulty for human beings, which often causes anxiety, depression, and other mental symptoms, seriously affecting people’s quality of life. Hyperalgesia is one of the main adverse reactions of chronic pain. The mechanism of gut microbiota in hyperalgesia has been extensively studied, providing a new target for pain treatment. Enterochromaffin cells, as the chief sentinel for sensing gut microbiota and its metabolites, can play an important role in the interaction between the gut microbiota and hyperalgesia through paracrine or neural pathways. Therefore, this systematic review describes the role of gut microbiota in the pathological mechanism of hyperalgesia, learns about the role of enterochromaffin cell receptors and secretions in hyperalgesia, and provides a new strategy for pain treatment by targeting enterochromaffin cells through restoring disturbed gut microbiota or supplementing probiotics.

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Gut microbiota, immunity and pain

Cited by 35 publications

References 42 publications

A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat

A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat

Diet/Nutrition: Ready to Transition from a Cancer Recurrence/Prevention Strategy to a Chronic Pain Management Modality for Cancer Survivors?

Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?

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