Gut microbiota in health and disease

Ganguly, Shreyashi; Chandrasekhara, Pradeep Kumar Shenoy

doi:10.4103/2666-1802.260257

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding suggests that the administration of M. cordata extracts induces gastrointestinal diseases and hepatotoxicity in mice. An increasing number of studies have reported that gut microbiota is closely related to human health ( 24 ). Gut microbial communities are involved in neurological diseases by modulating the microbiota–gut–brain axis ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.—A Bioactivity Guided Approach

Yang

Liu

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

Macleaya cordata (Willd.) R. Br. (M. cordata) is a perennial herb known for its chemotherapeutic properties, strong feeding additive, and potential antidiarrheal drug. Despite its therapeutic potentials, its clinical applications are hindered by an apparent lack of toxicity data. In this study, the toxic ingredients of this plant were investigated using a bioactivity-guided approach. Two compounds, protopine and allocryptopine, were purified and elucidated by LC-MS, 1H-NMR, and 13C-NMR. Protopine, a primary component in M. cordata, had an LD50 of 313.10 mg/kg i.e., which was considered toxic. An autopsy was performed on protopine-administered mice, and the histopathology of the kidney, liver, brain, heart, lung, and spleen was determined. Autopsy findings included hemorrhage in the respiratory system, lung congestion, and hemorrhage and edema in the parenchymatous organs (heart, liver, kidney, and brain). Histopathology confirmed the pathological changes in the brain, liver, and kidney. Protopine is one of the principal bioactive constituents of many phytopreparations used in veterinary and human medicine, such as Sangrovit and Iberogast. Our findings indicated that phytopreparations containing protopine might pose a serious health threat to humans and animals.

show abstract

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies have reported that gut microbiota is closely related to human health ( 24 ). Gut microbial communities are involved in neurological diseases by modulating the microbiota–gut–brain axis ( 24 ). Studies have shown that drug-induced liver injury is linked to gut microbiota dysbiosis ( 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.—A Bioactivity Guided Approach

Yang

Liu

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

Gut microbiota in health and disease

Cited by 1 publication

References 0 publications

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.—A Bioactivity Guided Approach

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.—A Bioactivity Guided Approach

Contact Info

Product

Resources

About