Gut microbiota in muscular atrophy development, progression, and treatment: New therapeutic targets and opportunities

Chen, Shujie; Zhang, Puxuan; Duan, Huimin; Wang, Jie; Qiu, Y. L.; Long, Yong; Yin, Yue; Wan, Dan; Xie, Liwei

doi:10.1016/j.xinn.2023.100479

Cited by 11 publications

(5 citation statements)

References 140 publications

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“…However, when this balance is disrupted, dysbiosis can occur, leading to an imbalance of the microbiota, which is associated with the development of various diseases, including inflammatory bowel disease, obesity, and cardiovascular diseases. 77 Probiotics can regulate the balance of the gut microbiota in several ways. 78 First, they can directly inhibit the growth of pathogens by producing antimicrobial substances (such as bacteriocins and organic acids) or through competitive exclusion by competing with pathogens for nutrients or attachment sites.…”

Section: Regulating the Balance Of Gut Microbiotamentioning

confidence: 99%

“…A healthy gut microbiome should have a dynamic balance between beneficial and harmful bacteria. However, when this balance is disrupted, dysbiosis can occur, leading to an imbalance of the microbiota, which is associated with the development of various diseases, including inflammatory bowel disease, obesity, and cardiovascular diseases . Probiotics can regulate the balance of the gut microbiota in several ways .…”

Section: Controlled Delivery Of Probiotics In Gastrointestinal Tractmentioning

confidence: 99%

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Microfluidic Strategies for Encapsulation, Protection, and Controlled Delivery of Probiotics

Wang,

Huang,

Wang

et al. 2024

J. Agric. Food Chem.

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Probiotics are indispensable for maintaining the structure of gut microbiota and promoting human health, yet their survivability is frequently compromised by environmental stressors such as temperature fluctuations, pH variations, and mechanical agitation. In response to these challenges, microfluidic technology emerges as a promising avenue. This comprehensive review delves into the utilization of microfluidic technology for the encapsulation and delivery of probiotics within the gastrointestinal tract, with a focus on mitigating obstacles associated with probiotic viability. Initially, it elucidates the design and application of microfluidic devices, providing a precise platform for probiotic encapsulation. Moreover, it scrutinizes the utilization of carriers fabricated through microfluidic devices, including emulsions, microspheres, gels, and nanofibers, with the intent of bolstering probiotic stability. Subsequently, the review assesses the efficacy of encapsulation methodologies through in vitro gastrointestinal simulations and in vivo experimentation, underscoring the potential of microfluidic technology in amplifying probiotic delivery efficiency and health outcomes. In sum, microfluidic technology represents a pioneering approach to probiotic stabilization, offering avenues to cater to consumer preferences for a diverse array of functional food options.

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Section: Regulating the Balance Of Gut Microbiotamentioning

confidence: 99%

Section: Controlled Delivery Of Probiotics In Gastrointestinal Tractmentioning

confidence: 99%

Microfluidic Strategies for Encapsulation, Protection, and Controlled Delivery of Probiotics

Wang,

Huang,

Wang

et al. 2024

J. Agric. Food Chem.

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“…The term ‘neurobiotics’ has been coined to indicate the possibility of targeting the microbiota to treat neurological diseases (Herrera-Rincon et al., 2022). It has been postulated that targeting the gut microbiota can mitigate the progression of muscle atrophy-related diseases in animal models, giving the possibility of modulating the gut microbiota for skeletal muscle (Chen et al., 2023). It has also been demonstrated that administration of Lactobacillus rhamnosus may improve the regeneration of the extensor digitorum longus muscle in mice (Jabeen and Qazi, 2023).…”

Section: Regenerative Medicinementioning

confidence: 99%

Muscle preservation in proximal nerve injuries: a current update

Lysak,

Farnebo,

Geuna

et al. 2024

J Hand Surg Eur Vol

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Optimal recovery of muscle function after proximal nerve injuries remains a complex and challenging problem. After a nerve injury, alterations in the affected muscles lead to atrophy, and later degeneration and replacement by fat-fibrous tissues. At present, several different strategies for the preservation of skeletal muscle have been reported, including various sets of physical exercises, muscle massage, physical methods (e.g. electrical stimulation, magnetic field and laser stimulation, low-intensity pulsed ultrasound), medicines (e.g. nutrients, natural and chemical agents, anti-inflammatory and antioxidants, hormones, enzymes and enzyme inhibitors), regenerative medicine (e.g. growth factors, stem cells and microbiota) and surgical procedures (e.g. supercharge end-to-side neurotization). The present review will focus on methods that aimed to minimize the damage to muscles after denervation based on our present knowledge.

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“…Therefore, on the basis of the wideranging effects of gut flora on the entire body, it is reasonable to hypothesize that there may be a potential link to frailty. Recent studies have highlighted the influence of the GM on skeletal muscle (14); specifically, gut flora has been shown to regulate metabolic homeostasis and insulin sensitivity in skeletal muscle and to promote an inflammatory response in skeletal muscle, which in turn affects many aspects of muscle, including mass, function, and metabolic processes (14,15). Subsequent skeletal muscle changes have been linked to loss of independence and reduced quality of life; further, they may comprise the underlying cause of frailty.…”

Section: Introductionmentioning

confidence: 99%

Exploring the causal relationship between gut microbiota and frailty: a two-sample mendelian randomization analysis

Bo,

Teng,

Shi

et al. 2024

Front. Med.

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BackgroundFrailty is a complex geriatric syndrome that seriously affects the quality of life of older adults. Previous observational studies have reported a strong relationship of frailty with the gut microbiota; however, further studies are warranted to establish a causal link. Accordingly, we aimed to conduct a bidirectional Mendelian randomization study to assess the causal relationship between frailty, as measured by the frailty index, and gut microbiota composition.MethodsInstrumental variables for the frailty index (N = 175, 226) and 211 gut bacteria (N = 18,340) were obtained through a genome-wide association study. A two-sample Mendelian randomization analysis was performed to assess the causal relationship of gut microbiota with frailty. Additionally, we performed inverse Mendelian randomization analyses to examine the direction of causality. Inverse variance weighting was used as the primary method in this study, which was supplemented by horizontal pleiotropy and sensitivity analyses to increase confidence in the results.ResultsBacteroidia (b = −0.041, SE = 0.017, p = 0.014) and Eubacterium ruminantium (b = −0.027, SE = 0.012, p = 0.028) were protective against frailty amelioration. Additionally, the following five bacteria types were associated with high frailty: Betaproteobacteria (b = 0.049, SE = 0.024, p = 0.042), Bifidobacterium (b = 0.042, SE = 0.016, p = 0.013), Clostridium innocuum (b = 0.023, SE = 0.011, p = 0.036), E. coprostanoligenes (b = 0.054, SE = 0.018, p = 0.003), and Allisonella (b = 0.032, SE = 0.013, p = 0.012). Contrastingly, frailty affected Butyrivibrio in the gut microbiota (b = 1.225, SE = 0.570, p = 0.031). The results remained stable within sensitivity and validation analyses.ConclusionOur findings strengthen the evidence of a bidirectional causal link between the gut microbiota and frailty. It is important to elucidate this relationship to optimally enhance the care of older adults and improve their quality of life.

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Gut microbiota in muscular atrophy development, progression, and treatment: New therapeutic targets and opportunities

Cited by 11 publications

References 140 publications

Microfluidic Strategies for Encapsulation, Protection, and Controlled Delivery of Probiotics

Microfluidic Strategies for Encapsulation, Protection, and Controlled Delivery of Probiotics

Muscle preservation in proximal nerve injuries: a current update

Exploring the causal relationship between gut microbiota and frailty: a two-sample mendelian randomization analysis

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