Gut Microbiota Interactions With Obesity

Falalyeyeva, Tetyana; Chornenka, N. M.; Cherkasova, L.V.; Tsyryuk, Olena; Molchek, Nataliia; Kovalchuk, Oleksandr; Kyriachenko, Yevheniia; Li, Ostapchenko; Kobyliak, Nazarii

doi:10.1016/b978-0-12-819265-8.00030-9

Cited by 14 publications

(12 citation statements)

References 166 publications

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“…Bacteria of the genus Faecalibacterium , abundant butyric acid-producing bacteria colonizing the human gut, display anti-inflammatory effects and may be used as potential probiotics for treatment of gut inflammation [84] , [85] . Ruminococcus members, breakdown cellulose (with the formation of methane) and accumulate a reserve iodophilic polymer of glucose in the cytoplasm [86] . Blautia is widely distributed in mammalian feces and intestines.…”

Section: Resultsmentioning

confidence: 99%

Exploring the universal healthy human gut microbiota around the World

Piquer-Esteban

Ruiz-Ruiz

Arnau

et al. 2022

Computational and Structural Biotechnology Journal

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Section: Resultsmentioning

confidence: 99%

Exploring the universal healthy human gut microbiota around the World

Piquer-Esteban

Ruiz-Ruiz

Arnau

et al. 2022

Computational and Structural Biotechnology Journal

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“…Phascolarctobacterium was increased in mice but decreased in mice fed with an HFD and supplemented with BCAAs (Falalyeyeva et al, 2022).…”

Section: Frontiers In Microbiology 12mentioning

confidence: 97%

Oral administration of branched-chain amino acids ameliorates high-fat diet-induced metabolic-associated fatty liver disease via gut microbiota-associated mechanisms

Zhang

et al. 2022

Front. Microbiol.

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Branched-chain amino acids (BCAAs), essential amino acids for the human body, are mainly obtained from food. High levels of BCAAs in circulation are considered as potential markers of metabolic-associated fatty liver disease (MAFLD) in humans. However, there are conflicting reports about the effects of supplement of BCAAs on MAFLD, and research on BCAAs and gut microbiota is not comprehensive. Here, C57BL/6J mice were fed with a high-fat diet with or without BCAAs to elucidate the effects of BCAAs on the gut microbiota and metabolic functions in a mouse model of MAFLD. Compared to high-fat diet (HFD) feeding, BCAA supplementation significantly reduced the mouse body weight, ratio of liver/body weight, hepatic lipid accumulation, serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and alanine aminotransferase (ALT), and the expressions of the lipogenesis-related enzymes Fas, Acc, and Scd-1 and increased expressions of the lipolysis-related enzymes Cpt1A and Atgl in the liver. BCAAs supplementation also counteracted HFD-induced elevations in serum BCAAs levels by stimulating the enzymatic activity of BCKDH. Furthermore, BCAAs supplementation markedly improved the gut bacterial diversity and altered the gut microbiota composition and abundances, especially those of genera, in association with MAFLD and BCAAs metabolism. These data suggest that BCAA treatment improves HFD-induced MAFLD through mechanisms involving intestinal microbes.

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“…En Pa se observó una mayor abundancia relativa de la Clostridiales en comparación a Po. En humanos, la disminución en la abundancia relativa de Clostriadiales se ha asociado con el desarrollo de síndrome metabólico (Falalyeyeva et al, 2022) y con síndrome de colon irritable (Rangel et al, 2015). En equinos se ha demostrado que un incremento en la abundancia de Clostridiales puede estimular la respuesta inmune (Lindenberg et al, 2019), debido a lo anterior es posible que Pa presenten una mejor respuesta inmune en comparación a las Po.…”

Section: Discussionunclassified

Caracterización De La Microbiota Fecal en Caballos Con Ciatostomosis en México

Martínez-Ortiz-de-Montellano

Márquez-Mota

Montes-Carreto

et al. 2023

Trop Subtrop Agroecosyst

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Background: The excess of antimicrobials and anthelmintics cause important dysbiosis processes in equines, as well as resistance phenomena mainly in the communities of bacteria, archaea, protozoa, and helminths. The study of the equine microbiome is becoming more and more relevant to understand the biotic processes of the gastrointestinal tract. In colon and cecum, the role of cyathostomins as part of the microbiome is still unexplored. While interaction with certain bacterial groups may be key to the understanding of parasitism. Objective: To characterize the microbiota in feces of yearling naturally infected with cyathostomins in a quarter-horse farm in Sierra de Lobos, Guanajuato, Mexico. Methodology: Weights were measured and obtained the parasite burden in feces, from which samples were transfer and processing in the laboratory for DNA extraction and later sent for sequencing and analysis. Results: Average weight of the colts was 399 kg, and the average weight of the fillies was 432 kg. All horses were high shedders: 1,390 ± 698 egg per gram of feces. Alpha and beta diversity analyses indicated no differences within the microbial community between colts and fillies. Main bacteria at Phyla in both groups (females; males) were Bacteroidetes (37%; 37%), Firmicutes (46%; 37%), Verrucomicrobia (4%; 10%), Spirochaetes 5%; 4%) and Proteobacteria (1%; 3%). At Class level the principal identified groups were Bacteroidia (31%; 31%), Clostridia (43%; 35%), at Order level are Bacteroidales (31%; 31%) and Clostridiales (43%; 35%). Main bacteria at Family level were Ruminococcaceae (19%; 11%), Lachnospiraceae (15%; 6%) and non-assigned family Bacteriodales (19%; 21%). The most abundant non-assigned bacterial Genra were Bacteroidales (26%; 27%), Ruminococcaceae (10%; 5%) y Lachnospiraceae (9%; 6%); the assigned bacterial Genra were Clostridium (5%; 9%) and Treponema (4% y 3%). The most abundant non-assigned bacterial Species were Methanocorpusculaceae sp (19%; 22%), Pedobacter sp (10%; 5%), Bacteroidales sp (9% y 6%) and Prevotella sp (4% y 3%); the assigned bacterial species were Fibrobacter succinogenes (2%; 1%), Succinispira mobilis (1%; 1%). Implications: It is suggested that environmental factors and feeding are aspects that regulate the parasitic burden and the bacterial composition in this studied population. This is a short communication of the finding of the components of the microbiota and is relevant in Mexico for future studies, however it is imperative to explore the composition of the metacommunity of a horse free of cyathostomines. Conclusion: Considering that these nematodes are in the cecum and colon, where this microbiota was inferred, and that it is not known whether this interaction is beneficial or detrimental, the study of the microbiome is imperative. In the study, no horse presented clinical signs or colic due to the presence of nematodes.

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Gut Microbiota Interactions With Obesity

Cited by 14 publications

References 166 publications

Exploring the universal healthy human gut microbiota around the World

Exploring the universal healthy human gut microbiota around the World

Oral administration of branched-chain amino acids ameliorates high-fat diet-induced metabolic-associated fatty liver disease via gut microbiota-associated mechanisms

Caracterización De La Microbiota Fecal en Caballos Con Ciatostomosis en México

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