Gut microbiota mediates the alleviative effect of polar lipids-enriched milk fat globule membrane on obesity-induced glucose metabolism disorders in peripheral tissues in rat dams

Li, Tiange; Yuan, Qichen; Gong, Han; Du, Min; Mao, Xueying

doi:10.1038/s41366-021-01029-4

Cited by 13 publications

(9 citation statements)

References 58 publications

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“…Maternal diet could affect the gut microbiota of offspring through vertically transmitted to the offspring during delivery, thus diet-induced changes in the gut microbiota of the mothers can directly affect the colonization of the gut microbiota of offspring (46). A previous study has found that administration of polar lipids-enriched MFGM in obese dams during pregnancy and lactation could restore the ratio of Firmicutes to Bacteroides, reduce the relative abundance of Ruminococcaceae and Enterococcus, and increase the relative abundance of Akkermansia (25), which were similar to the changes in the gut microbiota of offspring observed in the present study. Therefore, the beneficial effect of MFGM on the gut microbiota of offspring may be attributed to the improvement of the gut microbiota of dams.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, MFGM could alleviate endotoxemia by improving the gut microbiota of obese mice ( 24 ). MFGM supplementation during pregnancy and lactation ameliorated dysbiosis of obese rat dams ( 25 ), indicating that MFGM is favorable for obesity-related gut microbiota and inflammatory status. Based on these studies, the effects of MFGM supplementation to HFD-induced obese dams during pregnancy and lactation on the neurodevelopment of offspring were measured, and the corresponding changes in the gut microbiota and inflammatory responses were explored, which promoted neurodevelopment.…”

Section: Introductionmentioning

confidence: 99%

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Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring via modulating gut microbiota

Yuan

Gong

et al. 2022

Front. Nutr.

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Pre-pregnancy obesity and high-fat diet (HFD) during pregnancy and lactation are associated with neurodevelopmental delay in offspring. This study aimed to investigate whether milk fat globule membrane (MFGM) supplementation in obese dams could promote neurodevelopment in offspring. Obese female rats induced by HFD were supplemented with MFGM during pregnancy and lactation. Maternal HFD exposure significantly delayed the maturation of neurological reflexes and inhibited neurogenesis in offspring, which were significantly recovered by maternal MFGM supplementation. Gut microbiota analysis revealed that MFGM supplementation modulated the diversity and composition of gut microbiota in offspring. The abundance of pro-inflammatory bacteria such as Escherichia shigella and Enterococcus were down-regulated, and the abundance of bacteria with anti-inflammatory and anti-obesity functions, such as Akkermansia and Lactobacillus were up-regulated. Furthermore, MFGM alleviated neuroinflammation by decreasing the levels of lipopolysaccharides (LPS) and pro-inflammatory cytokines in the circulation and brain, as well as inhibiting the activation of microglia. Spearman’s correlation analysis suggested that there existed a correlation between gut microbiota and inflammation-related indexes. In conclusion, maternal MFGM supplementation promotes neurodevelopment partly via modulating gut microbiota in offspring.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring via modulating gut microbiota

Yuan

Gong

et al. 2022

Front. Nutr.

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“…Millar et al found that 2% MPLs in HFD-fed mice modulated gut microbiota via significantly different Jaccard and Bray-Curtis beta diversity indices [ 11 ]. Similarly, 400 mg/kg polar-lipid enriched milk fat globule membrane in pregnant and lactating female Sprague Dawley rats enhanced alpha diversity measures of gut microbiota including Ace, Chao, Simpson, and Shannon indexes after 8 weeks [ 39 ]. As LFD-fed male mice supplemented with 2% MPL in the current study had both increased fecal bacterial diversity and increased colon inflammation compared to LFD control diet, our data suggest that the increased fecal bacterial diversity seen with MPL feeding in mice may not always coincide with reductions in colon inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Milk Polar Lipids on DSS-Induced Colitis Severity Are Dependent on Dietary Fat Content

2022

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In the United States, over three million adults suffer from inflammatory bowel disease (IBD). The gut microbiome, host immune response, and nutrient-microbial interactions are known to play a role in IBD. The relationship between dairy and IBD is controversial; thus, the objectives of this study were to identify how milk polar lipids (MPLs) and anhydrous milk fat affect colitis disease activity, the colonic transcriptome, and the gut microbiome in a mouse model of chemical-induced colitis. Male and female C57BL6/J mice (n = 120) were randomized into either a low (5% w/w) milk fat or a high (21% w/w) milk fat diet supplemented with either 0%, 1%, or 2% w/w of MPLs for three weeks (n = 10/group/sex). Afterwards, colitis was induced using 1% dextran sodium sulfate in drinking water for five days (colitis induction) and then switched to regular water for five days (colitis recovery). Mice fed added MPLs were protected against colitis when fed a high-fat diet, while added MPLs during low-fat diet attenuated disease activity during the colitis induction period yet promoted colitis and inflammation in male mice during the recovery period. Dietary fat content can alter colitis and influence the anti-inflammatory effect of milk polar lipids.

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“…Moreover, Li and colleagues provided evidence for the supplementation during pregnancy of MFGM to promote brown/beige adipocyte development and to prevent obesity in male offspring born from HFD-dams rats [ 157 ]. These same authors showed that MFGM may act through the modulation of gut microbiota to alleviate obesity-induced glucose metabolism disorders in peripheral tissues in rat dams [ 158 ]. Indeed, as mentioned above, MFGM is able to decrease gut permeability, which could attenuate gut-derived endotoxin translocation and the associated inflammatory responses supporting its use during pregnancies characterized by a general inflammatory condition such as those associated to obesity or hypercaloric unbalanced diets.…”

Section: Nutritional Strategies To Counteract Maternal Obesitymentioning

confidence: 99%

Inflammatory Signatures of Maternal Obesity as Risk Factors for Neurodevelopmental Disorders: Role of Maternal Microbiota and Nutritional Intervention Strategies

et al. 2022

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Obesity is a main risk factor for the onset and the precipitation of many non-communicable diseases. This condition, which is associated with low-grade chronic systemic inflammation, is of main concern during pregnancy leading to very serious consequences for the new generations. In addition to the prominent role played by the adipose tissue, dysbiosis of the maternal gut may also sustain the obesity-related inflammatory milieu contributing to create an overall suboptimal intrauterine environment. Such a condition here generically defined as “inflamed womb” may hold long-term detrimental effects on fetal brain development, increasing the vulnerability to mental disorders. In this review, we will examine the hypothesis that maternal obesity-related gut dysbiosis and the associated inflammation might specifically target fetal brain microglia, the resident brain immune macrophages, altering neurodevelopmental trajectories in a sex-dependent fashion. We will also review some of the most promising nutritional strategies capable to prevent or counteract the effects of maternal obesity through the modulation of inflammation and oxidative stress or by targeting the maternal microbiota.

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Gut microbiota mediates the alleviative effect of polar lipids-enriched milk fat globule membrane on obesity-induced glucose metabolism disorders in peripheral tissues in rat dams

Cited by 13 publications

References 58 publications

Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring via modulating gut microbiota

Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring via modulating gut microbiota

Effects of Milk Polar Lipids on DSS-Induced Colitis Severity Are Dependent on Dietary Fat Content

Inflammatory Signatures of Maternal Obesity as Risk Factors for Neurodevelopmental Disorders: Role of Maternal Microbiota and Nutritional Intervention Strategies

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