Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis

Li, Yuan; Xiao, He; Dong, Jing; Luo, Di; Wang, Haichao; Zhang, Shuqin; Zhu, Tong; Zhu, Changchun; Cui, Ming; Fan, Saijun

doi:10.3389/fmicb.2020.01450

Cited by 19 publications

(12 citation statements)

References 64 publications

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“…Emil Grubbe’s treatment of breast cancer with radiotherapy back in 1896 ( Hodges, 1964 ), pioneered modern cancer radiation therapy. As the number of patients receiving radiation increases steadily, the incidence of radiotherapy-associated complications has risen in parallel ( Theis et al., 2010 ; Li et al., 2020b ). While radiotherapy improves the survival of cancer patients ( Hale, 2020 ), the oxidative stress caused by radiotherapy can produce reactive oxide species (ROS), which result in broad DNA damage to normal tissues, e.g., the gastrointestinal mucosa ( Kumagai et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Gut Microbiota on Radiation-Induced Enteritis

Jian

Zhang

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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Radiotherapy is an important treatment for abdominal tumors. A critical side effect for this therapy is enteritis. In this review, we aim to summarize recent findings in radiation enteritis, in particular the role of gut microbiota dysbiosis in the development and therapy of the disease. Gut microbiota dysbiosis plays an important role in the occurrence of various diseases, such as radiation enteritis. Abdominal radiation results in changes in the composition of microbiota and reduces its diversity, which is mainly reflected in the decrease of Lactobacillus spp. and Bifidobacterium spp. and increase of Escherichia coli and Staphylococcus spp. Gut microbiota dysbiosis aggravates radiation enteritis, weakens intestinal epithelial barrier function, and promotes inflammatory factor expression. Pathogenic Escherichia coli induce the rearrangement and redistribution of claudin-1, occludin, and ZO-1 in tight junctions, a critical component in intestinal epithelial barrier. In view of the role that microbiome plays in radiation enteritis, we believe that intestinal flora could be a potential biomarker for the disease. Correction of microbiome by application of probiotics, fecal microbiota transplantation (FMT), and antibiotics could be an effective method for the prevention and treatment of radiation-induced enteritis.

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Section: Introductionmentioning

confidence: 99%

The Impact of Gut Microbiota on Radiation-Induced Enteritis

Jian

Zhang

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Radiotherapy is the cornerstone of modern management methods of malignant tumors, but it can also cause damage to normal tissues and produce a variety of side effects, affecting the treatment results and the quality of life of patients [ 62 ]. Cancer and its treatment have a negative impact on the gut microbiota, often leading to ecological imbalance.…”

Section: Interactions Between Gut Microbiota and Radiotherapymentioning

confidence: 99%

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Zuo

et al. 2022

Nutrients

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Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota.

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“…As an organ, the intestine comprises many different cell types, including vascular, enteric immune, and nervous system cells, all of which are influenced by irradiation to various degrees 130 . Radiation exposure damages the intestinal barrier, alters the abundance and composition of gut microbiota, and causes apoptosis in intestinal crypts 17 , 19 , 131 , 132 . The pathogenesis of enteritis, colitis, and diarrhea in mouse models and patients receiving radiation therapy has been found to be associated with a gut flora imbalance, which limits therapy completion 133 .…”

Section: The Microbiome and Cancer Radiotherapymentioning

confidence: 99%

Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy

Dong¹,

Li²,

Xiao³

et al. 2021

Cancer Biol. Med.

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The human microflora is a complex ecosystem composed of diverse microorganisms mainly distributed in the epidermal and mucosal habitats of the entire body, including the mouth, lung, intestines, skin, and vagina. These microbial communities are involved in many essential functions, such as metabolism, immunity, host nutrition, and diseases. Recent studies have focused on the microbiota associated with cancers, particularly the oral and intestinal microbiota. Radiotherapy, the most effective cytotoxic modality available for solid tumors, contributes to the treatment of cancer patients. Mounting evidence supports that the microbiota plays pivotal roles in the efficacy and prognosis of tumor radiotherapy. Here, we review current research on the microbiota and cancer development, and describe knowledge gaps in the study of radiotherapy and the microbiota. Better understanding of the effects of the microbiome in tumorigenesis and radiotherapy will shed light on future novel prevention and treatment strategies based on modulating the microbiome in cancer patients. KEYWORDSOral microbiome; gut microbiome; cancer; radiotherapy Overview of the oral microbiome and cancer developmentThe oral microflora, the microbial community existing in the human oral cavity, comprises more than 700 bacterial species

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Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis

Cited by 19 publications

References 64 publications

The Impact of Gut Microbiota on Radiation-Induced Enteritis

The Impact of Gut Microbiota on Radiation-Induced Enteritis

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy

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