Gut microbiota of Parkinson’s disease in an appendectomy cohort: a preliminary study

Nakahara, Keiichi; Nakane, Shunya; Ishii, Kazuo; Ikeda, Tokunori; Ando, Yukio

doi:10.1038/s41598-023-29219-2

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…LPS found on E. coli strains and other Enterobacteriaceae members, are considered to be the most immunogenic forms of LPS [162,163]. Notably, Enterobacteriaceae have an increased presence in the gut microbiota of PwP along with other Gram-negative LPS-producing families Veruccomicrobioaceae and Christensenellaceae [93,94,98,102,106,110,118,123] and Klebsiella species, and Porphyromonas asaccharolytica [124]. In the field of neurodegenerative disease, there has been a prevailing assumption that secreted, non-vesicleassociated factors, such as free LPS, breach the intestinal barrier and trigger an immune response that contributes to disease progression.…”

Section: Inflammation and The Microbiota-gut-brain Axis In Pdmentioning

confidence: 99%

Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease?

Koukoulis,

Beauchamp,

Kaparakis-Liaskos

et al. 2024

Journal of Parkinson’s Disease

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Parkinson’s disease (PD) is an increasingly common neurodegenerative disease. It has been suggested that the etiology of idiopathic PD is complex and multifactorial involving environmental contributions, such as viral or bacterial infections and microbial dysbiosis, in genetically predisposed individuals. With advances in our understanding of the gut-brain axis, there is increasing evidence that the intestinal microbiota and the mammalian immune system functionally interact. Recent findings suggest that a shift in the gut microbiome to a pro-inflammatory phenotype may play a role in PD onset and progression. While there are links between gut bacteria, inflammation, and PD, the bacterial products involved and how they traverse the gut lumen and distribute systemically to trigger inflammation are ill-defined. Mechanisms emerging in other research fields point to a role for small, inherently stable vesicles released by Gram-negative bacteria, called outer membrane vesicles in disease pathogenesis. These vesicles facilitate communication between bacteria and the host and can shuttle bacterial toxins and virulence factors around the body to elicit an immune response in local and distant organs. In this perspective article, we hypothesize a role for bacterial outer membrane vesicles in PD pathogenesis. We present evidence suggesting that these outer membrane vesicles specifically from Gram-negative bacteria could potentially contribute to PD by traversing the gut lumen to trigger local, systemic, and neuroinflammation. This perspective aims to facilitate a discussion on outer membrane vesicles in PD and encourage research in the area, with the goal of developing strategies for the prevention and treatment of the disease.

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Section: Inflammation and The Microbiota-gut-brain Axis In Pdmentioning

confidence: 99%

Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease?

Koukoulis,

Beauchamp,

Kaparakis-Liaskos

et al. 2024

Journal of Parkinson’s Disease

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“…Embora a α-sinucleína se agregue no apêndice vermiforme em quase todos os indivíduos, incluindo pacientes com DP, bem como indivíduos sem qualquer doença neurológica, a abundância de α-sinucleína na fração insolúvel do apêndice é maior em pacientes com DP em comparação com aquela em controles saudáveis (SVENSSON et al, 2015). Dessa forma, os achados indicam uma associação significativa entre a microbiota intestinal alterada e o papel do apêndice na patogênese da DP (NAKAHARA et al, 2023).…”

Section: Indivíduos Acometidos Por Distúrbios Neurológicos Comounclassified

Microbiota intestinal e a intrínseca relação com a Doença de Parkinson

Menezes,

Cação,

Oliveira

et al. 2024

Braz. J. Hea. Rev.

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Introdução: A microbiota intestinal possui um papel significativo no desenvolvimento e na homeostase de diferentes sistemas do corpo, incluindo o sistema nervoso central (SNC). A disbiose intestinal pode desempenhar um papel importante no desenvolvimento da doença de Parkinson (DP). Objetivos: Analisar a relação da microbiota intestinal com a doença de Parkinson, bem como avaliar o uso de probióticos como terapia. Metodologia: Trata-se de uma revisão narrativa realizada em bases de dados científicos digitais National Libary of Medicine (NLM) utilizando os descritores (DeCS/MeSH) utilizados, por sua vez, foram "Dysbiosis", "Parkinson Disease", "probiotics" e “gastrointestinal microbiome”. Esse processo foi composto por quatro etapas: identificação, seleção, elegibilidade e inclusão. Resultados: Pacientes com DP frequentemente apresentam disbiose intestinal. Ela está envolvida na secreção de ácidos graxos de cadeia curta e moduladores neuroinflamatórios como, dopamina, serotonina e GABA. Além disso, tem indício da relação nos corpos de Lewy. Nesse sentido, o uso de probióticos mostrou redução pontos positivos no tratamento, redução de sintomas e até prevenção da DP. Conclusão: A disbiose intestinal representa um fator de risco no desenvolvimento da DP e o uso de probióticos pode ser uma alternativa terapêutica.

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“…These findings are consistent with similar dysbiotic bacteria present in the gut of some PD patients. Staining of intestinal biopsies of early diagnosed PD patients show elevated levels of Escherichia coli (E. coli) [47]. Furthermore, fecal samples of PD patients exhibit elevated levels of Enterobacteriaceae species, which are associated with inflammatory diseases [48,49].…”

Section: Pathobionts and Pathogens As Triggers Of Neurological Sympto...mentioning

confidence: 99%

Gut Microbiota as a Modifier of Huntington’s Disease Pathogenesis

Khoshnan

2024

JHD

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Huntingtin (HTT) protein is expressed in most cell lineages, and the toxicity of mutant HTT in multiple organs may contribute to the neurological and psychiatric symptoms observed in Huntington’s disease (HD). The proteostasis and neurotoxicity of mutant HTT are influenced by the intracellular milieu and responses to environmental signals. Recent research has highlighted a prominent role of gut microbiota in brain and immune system development, aging, and the progression of neurological disorders. Several studies suggest that mutant HTT might disrupt the homeostasis of gut microbiota (known as dysbiosis) and impact the pathogenesis of HD. Dysbiosis has been observed in HD patients, and in animal models of the disease it coincides with mutant HTT aggregation, abnormal behaviors, and reduced lifespan. This review article aims to highlight the potential toxicity of mutant HTT in organs and pathways within the microbiota-gut-immune-central nervous system (CNS) axis. Understanding the functions of Wild-Type (WT) HTT and the toxicity of mutant HTT in these organs and the associated networks may elucidate novel pathogenic pathways, identify biomarkers and peripheral therapeutic targets for HD.

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Gut microbiota of Parkinson’s disease in an appendectomy cohort: a preliminary study

Cited by 6 publications

References 55 publications

Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease?

Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease?

Microbiota intestinal e a intrínseca relação com a Doença de Parkinson

Gut Microbiota as a Modifier of Huntington’s Disease Pathogenesis

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